Simvastatin and Mekinist drug interactions - a phase IV clinical study of FDA data

Summary:

Drug interactions are reported among people who take Simvastatin (simvastatin) and Mekinist (trametinib dimethyl sulfoxide). Common drug interactions include feeding disorder among females and rash among males.

The phase IV clinical study analyzes what interactions people have when they take Simvastatin and Mekinist. It is created by eHealthMe based on reports of 68 people who take the same drugs from the FDA, and is updated regularly.

What is Simvastatin?

Simvastatin has active ingredients of simvastatin. It is often used in high blood cholesterol. eHealthMe is studying from 256,970 Simvastatin users. Check the latest studies of Simvastatin.

What is Mekinist?

Mekinist has active ingredients of trametinib dimethyl sulfoxide. eHealthMe is studying from 17,350 Mekinist users. Check the latest studies of Mekinist.

On Aug, 12, 2026

68 people who take Simvastatin and Mekinist together, and have interactions are studied.

Simvastatin and Mekinist drug interactions.

What are the common drug interactions of Simvastatin and Mekinist, by gender? *:

female:

Feeding disorder (when children refuse to eat certain food groups)
Hypercalcaemia (elevated calcium (ca+) level in the blood)
Nausea (feeling of having an urge to vomit)
Non-small cell lung cancer metastatic (type of epithelial lung cancer spreads to other parts)
Rash
Retching (strong involuntary effort to vomit)
Urinary tract infection
Acne (skin problems that cause pimples)
Alopecia (absence of hair from areas of the body)
Anaemia (lack of blood)

male:

Rash
Fatigue (feeling of tiredness)
Death
Urticaria (rash of round, red welts on the skin that itch intensely)
Neoplasm (tumour)
Escherichia urinary tract infection (urinary tract infection by escherichia coli)
Kidney infection
Nephrolithiasis (calculi in the kidneys)
Pain
Procedural pain

What are the common drug interactions of Simvastatin and Mekinist, by age (0-1 to 60+)? *:

0-1:

n/a

2-9:

n/a

10-19:

n/a

20-29:

n/a

30-39:

n/a

40-49:

n/a

50-59:

Photopsia (presence of perceived flashes of light)
Rash
Somnolence (a state of near-sleep, a strong desire for sleep)
Staring (a prolonged gaze or fixed look)
Urinary retention (the inability to completely or partially empty the bladder)
Visual field defect
Pain
Escherichia urinary tract infection (urinary tract infection by escherichia coli)
Kidney infection
Nephrolithiasis (calculi in the kidneys)

60+:

Pyrexia (fever)
Fatigue (feeling of tiredness)
Diarrhoea
Death
Neoplasm (tumour)
Pruritus (severe itching of the skin)
Urticaria (rash of round, red welts on the skin that itch intensely)
Asthenia (weakness)
Blood calcium increased
Colitis (inflammation of colon)

What are the existing conditions these people have? *

Malignant Melanoma (skin cancer rises from melancytes): 22 people, 32.35%
Metastatic Malignant Melanoma (spreadable cancer tumour of melanine): 18 people, 26.47%
Multiple Myeloma (cancer of the plasma cells): 7 people, 10.29%
High Blood Pressure: 6 people, 8.82%
Neoplasm Malignant (cancer tumour): 4 people, 5.88%

* Approximation only. Some reports may have incomplete information.

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