Spiriva respimat and Ozempic drug interactions - a phase IV clinical study of FDA data

Summary:

Drug interactions are reported among people who take Spiriva respimat (tiotropium bromide) and Ozempic (semaglutide). Common drug interactions include sciatica among females and metabolic acidosis among males.

The phase IV clinical study analyzes what interactions people have when they take Spiriva respimat and Ozempic. It is created by eHealthMe based on reports of 97 people who take the same drugs from the FDA, and is updated regularly.

What is Spiriva respimat?

Spiriva respimat has active ingredients of tiotropium bromide. It is often used in chronic obstructive pulmonary disease. eHealthMe is studying from 9,788 Spiriva respimat users. Check the latest studies of Spiriva respimat.

What is Ozempic?

Ozempic has active ingredients of semaglutide. It is often used in weight loss. eHealthMe is studying from 29,761 Ozempic users. Check the latest studies of Ozempic.

On Jul, 16, 2026

97 people who take Spiriva respimat and Ozempic together, and have interactions are studied.

Spiriva respimat and Ozempic drug interactions.

What are the common drug interactions of Spiriva Respimat and Ozempic, by gender? *:

female:

Sciatica (a set of symptoms including pain caused by general compression or irritation of one of five spinal nerve roots of each sciatic nerve)
Sinus pain
Thrombosis (formation of a blood clot inside a blood vessel)
Uterine leiomyoma (uterine benign tumour derived from smooth muscle)
Attention deficit hyperactivity disorder (a chronic condition including attention difficulty, hyperactivity, and impulsiveness)
Bacteraemia (presence of bacteria in the blood)
Bacterial sepsis
Blood glucose decreased
Bronchiectasis (abnormal widening of the bronchi or their branches, causing a risk of infection)
C-reactive protein increased

male:

Metabolic acidosis (body produces too much acid, or when the kidneys are not removing enough acid from the body)
Haematuria (presence of blood in urine)
Bronchitis (inflammation of the mucous membrane in the bronchial tubes)
Burning sensation
Dehydration (dryness resulting from the removal of water)
Dizziness
Drug ineffective
Dry mouth
Dyspnoea (difficult or laboured respiration)
Fatigue (feeling of tiredness)

What are the common drug interactions of Spiriva Respimat and Ozempic, by age (0-1 to 60+)? *:

0-1:

n/a

2-9:

n/a

10-19:

n/a

20-29:

n/a

30-39:

Bacteraemia (presence of bacteria in the blood)
Bacterial sepsis
Mental status changes (general changes in brain function, such as confusion, amnesia (memory loss), loss of alertness, loss of orientation)

40-49:

Dyspnoea (difficult or laboured respiration)
Attention deficit hyperactivity disorder (a chronic condition including attention difficulty, hyperactivity, and impulsiveness)
Drug ineffective
Fatigue (feeling of tiredness)
Feeling hot
Headache (pain in head)
Hypertension (high blood pressure)
Malaise (a feeling of general discomfort or uneasiness)
Memory impairment
Nervousness

50-59:

Pneumonia legionella (pneumonia caused by the bacteria legionella)
Sinusitis (inflammation of sinus)
Upper-airway cough syndrome
Abdominal pain
Abdominal pain upper
Blood pressure increased
Breast mass
Chest pain
Chills (felling of cold)
Dyspnoea (difficult or laboured respiration)

60+:

Dyspnoea (difficult or laboured respiration)
Dyspnoea exertional (breathlessness or shortness of breath)
Fall
Flank pain (a distressing sensation experienced around the lower back and the upper abdomen)
Influenza
Injury
Insomnia (sleeplessness)
Lower respiratory tract infection
Nasal congestion (blockage of the nasal passages usually due to membranes lining the nose becoming swollen from inflamed blood vessels)
Nasopharyngitis (inflammation of the nasopharynx)

What are the existing conditions these people have? *

Asthma: 62 people, 63.92%
Eczema (patches of skin become rough and inflamed, with itching and bleeding blisters): 50 people, 51.55%
Type 2 Diabetes: 9 people, 9.28%
Primary Pulmonary Hypertension (primary high blood pressure that affects the arteries in the lungs and the right side of your heart): 7 people, 7.22%
Stable Angina (a constant chest pain): 6 people, 6.19%
Immunodeficiency Common Variable: 6 people, 6.19%

* Approximation only. Some reports may have incomplete information.

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