Tapentadol and Calcium drug interactions - a phase IV clinical study of FDA data

Summary:

Drug interactions are reported among people who take Tapentadol (tapentadol) and Calcium (calcium). Common drug interactions include gait disturbance among females and actinic keratosis among males.

The phase IV clinical study analyzes what interactions people have when they take Tapentadol and Calcium. It is created by eHealthMe based on reports of 70 people who take the same drugs from the FDA, and is updated regularly.

What is Tapentadol?

Tapentadol has active ingredients of tapentadol. It is often used in chronic pain. eHealthMe is studying from 2,551 Tapentadol users. Check the latest studies of Tapentadol.

What is Calcium?

Calcium has active ingredients of calcium. It is often used in osteoporosis. eHealthMe is studying from 184,201 Calcium users. Check the latest studies of Calcium.

On Jul, 25, 2026

70 people who take Tapentadol and Calcium together, and have interactions are studied.

Tapentadol and Calcium drug interactions.

What are the common drug interactions of Tapentadol and Calcium, by gender? *:

female:

Gait disturbance
Gamma-glutamyltransferase increased
Heart valve incompetence (heart's valves do not work correctly)
Hypercalcaemia of malignancy (elevated calcium (ca+) level in the blood with cancer)
Hypoaesthesia (reduced sense of touch or sensation)
Injection site mass
Injection site pain
Laryngeal oedema (swelling of larynx)
Malignant neoplasm progression (cancer tumour came back)
Metastases to bone (cancer spreads to bone)

male:

Actinic keratosis (skin disease due to sun exposure)
Asthenia (weakness)
Blood pressure increased
Sepsis (a severe blood infection that can lead to organ failure and death)
Acidosis (build-up of carbon dioxide in the blood)
Cardiac arrest
Cholecystitis (infection of gallbladder)
Injection site extravasation (flow of (blood or lymph) from injection site)
Injection site swelling
Septic shock (shock due to blood infection)

What are the common drug interactions of Tapentadol and Calcium, by age (0-1 to 60+)? *:

0-1:

n/a

2-9:

n/a

10-19:

Cytokine release syndrome (immediate complication occurring with the use of anti-t cell antibody infusions)
Enterococcal sepsis
Metabolic acidosis (body produces too much acid, or when the kidneys are not removing enough acid from the body)

20-29:

n/a

30-39:

n/a

40-49:

Anaemia (lack of blood)
Arthralgia (joint pain)
Bone lesion (bone with abnormalities. bone lesions can result from growth formations, infections, or injuries)
Breast cancer
Breast mass
Breast swelling
Electrocardiogram qt prolonged
Gamma-glutamyltransferase increased
Hypercalcaemia of malignancy (elevated calcium (ca+) level in the blood with cancer)
Malignant neoplasm progression (cancer tumour came back)

50-59:

Hypertension (high blood pressure)
Neuropathy peripheral (surface nerve damage)
Acidosis (build-up of carbon dioxide in the blood)
Cardiac arrest
Cholecystitis (infection of gallbladder)
Sepsis (a severe blood infection that can lead to organ failure and death)
Septic shock (shock due to blood infection)
Heart rate increased
Empyema (collection of pus in a cavity in the body)
Fibula fracture

60+:

Asthenia (weakness)
Anaemia (lack of blood)
Actinic keratosis (skin disease due to sun exposure)
Fall
Herpes zoster
Orthostatic hypotension (a medical condition consisting of a sudden decrease in blood pressure when a person stands up)
Pneumonia pneumococcal (pneumococcal pneumonia is a common but serious infection and inflammation of the lungs)
Post herpetic neuralgia (neuralgia caused by the varicella zoster virus)
Post procedural swelling
Pain

What are the existing conditions these people have? *

Pain: 19 people, 27.14%
Multiple Myeloma (cancer of the plasma cells): 16 people, 22.86%
Agranulocytosis (a deficiency of granulocytes in the blood, causing increased vulnerability to infection): 14 people, 20.00%
Bone Pain: 12 people, 17.14%
Constipation: 12 people, 17.14%
Pain In Extremity: 10 people, 14.29%
Joint Pain: 9 people, 12.86%
Polymyalgia Rheumatica (pain in many muscles): 8 people, 11.43%
Nausea (feeling of having an urge to vomit): 7 people, 10.00%
High Blood Pressure: 7 people, 10.00%

* Approximation only. Some reports may have incomplete information.

Do you take Tapentadol and Calcium?

- Personalize this study to your gender, age, symptoms and drugs
- Predict drug outcomes for up to one year with AI
- Get an AI agent to monitor your drugs continuously