Topamax and Estring drug interactions - a phase IV clinical study of FDA data

Summary:

Drug interactions are reported among people who take Topamax (topiramate) and Estring (estradiol). Common drug interactions include urinary tract infection among females.

The phase IV clinical study analyzes what interactions people have when they take Topamax and Estring. It is created by eHealthMe based on reports of 33 people who take the same drugs from the FDA, and is updated regularly.

What is Topamax?

Topamax has active ingredients of topiramate. It is often used in migraine. eHealthMe is studying from 58,954 Topamax users. Check the latest studies of Topamax.

What is Estring?

Estring has active ingredients of estradiol. eHealthMe is studying from 5,474 Estring users. Check the latest studies of Estring.

On Jul, 25, 2026

33 people who take Topamax and Estring together, and have interactions are studied.

What are the common drug interactions of Topamax and Estring, by gender? *:

female:

Urinary tract infection
Drug ineffective
Sleep apnoea syndrome (a sleep-related disorder in which the effort to breathe is diminished or absent)
Abdominal hernia
Bronchitis (inflammation of the mucous membrane in the bronchial tubes)
Cystitis (inflammation of the wall of the bladder)
Cystocele (a condition that occurs when the tough fibrous wall between a woman's bladder and her vagina is torn by childbirth)
Depression
Dizziness
Dysphagia (a condition in which swallowing is difficult or painful)

male:

n/a

What are the common drug interactions of Topamax and Estring, by age (0-1 to 60+)? *:

0-1:

n/a

2-9:

n/a

10-19:

n/a

20-29:

n/a

30-39:

n/a

40-49:

Gastric bypass
Haemorrhoids (a swollen vein or group of veins in the region of the anus)
Hyponatraemia (abnormally low level of sodium in the blood; associated with dehydration)
Mental status changes (general changes in brain function, such as confusion, amnesia (memory loss), loss of alertness, loss of orientation)
Rhabdomyolysis (a condition in which damaged skeletal muscle tissue breaks down)
Drug ineffective
Vulvovaginal discomfort
Pain
Vulvovaginal pain
Limb injury

50-59:

Escherichia urinary tract infection (urinary tract infection by escherichia coli)
Abdominal hernia
Cystitis (inflammation of the wall of the bladder)
Cystocele (a condition that occurs when the tough fibrous wall between a woman's bladder and her vagina is torn by childbirth)
Depression
Dizziness
Dysphagia (a condition in which swallowing is difficult or painful)
Fall
Fatigue (feeling of tiredness)
Kidney infection

60+:

Escherichia sepsis (bacterial infection by escherichia coli)
Maculopathy (a condition or disease of the macula, the small spot in the retina where vision is keenest)
Urinary tract infection
Vulvovaginal discomfort
Vulvovaginal pain
Eye pain

What are the existing conditions these people have? *

Narcolepsy (brain's inability to regulate sleep-wake cycles normally): 14 people, 42.42%
Cataplexy (loss of muscle tone accompanied by full conscious awareness): 14 people, 42.42%
Vulvovaginal Dryness: 6 people, 18.18%
Cystitis Interstitial (unknown cause characterized by bladder pain): 4 people, 12.12%
Pain: 4 people, 12.12%
Asthma: 3 people, 9.09%
High Blood Cholesterol: 3 people, 9.09%
Urinary Tract Infection: 3 people, 9.09%
Hypothyroidism (abnormally low activity of the thyroid gland, resulting in retardation of growth and mental development): 3 people, 9.09%
Neurotrophic Keratopathy (decreased corneal sensitivity and poor corneal healing): 3 people, 9.09%

* Approximation only. Some reports may have incomplete information.

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