Tri-sprintec and Ibuprofen drug interactions - a phase IV clinical study of FDA data

Summary:

Drug interactions are reported among people who take Tri-sprintec (ethinyl estradiol; norgestimate) and Ibuprofen (ibuprofen). Common drug interactions include abdominal pain upper among females and cardiac disorder among males.

The phase IV clinical study analyzes what interactions people have when they take Tri-sprintec and Ibuprofen. It is created by eHealthMe based on reports of 84 people who take the same drugs from the FDA, and is updated regularly.

What is Tri-sprintec?

Tri-sprintec has active ingredients of ethinyl estradiol; norgestimate. It is often used in birth control. eHealthMe is studying from 1,428 Tri-sprintec users. Check the latest studies of Tri-sprintec.

What is Ibuprofen?

Ibuprofen has active ingredients of ibuprofen. It is often used in pain. eHealthMe is studying from 245,270 Ibuprofen users. Check the latest studies of Ibuprofen.

On Jul, 12, 2026

84 people who take Tri-sprintec and Ibuprofen together, and have interactions are studied.

Tri-sprintec and Ibuprofen drug interactions.

What are the common drug interactions of Tri-Sprintec and Ibuprofen, by gender? *:

female:

Abdominal pain upper
Anxiety
Dyspnoea (difficult or laboured respiration)
Infusion related reaction
Dizziness
Depression
Influenza like illness
Vomiting
Abdominal distension
Hodgkin's disease (cancer originating from white blood cells)

male:

Cardiac disorder
Heart injury
Maternal exposure during pregnancy (use of substance during pregnancy)

What are the common drug interactions of Tri-Sprintec and Ibuprofen, by age (0-1 to 60+)? *:

0-1:

n/a

2-9:

n/a

10-19:

Cerebrovascular accident (sudden death of some brain cells due to lack of oxygen when the blood flow to the brain is impaired by blockage or rupture)
Cholecystitis (infection of gallbladder)
Eyelid ptosis (falling of the upper or lower eyelid)
Facial paralysis (loss of function of face muscle)
Gallbladder disorder
Migraine (headache)
Musculoskeletal stiffness (stiffness of the body's muscles, joints, tendons, ligaments and nerves)
Neck pain
Pancreatitis chronic (chronic inflammation of pancreas)
Seizure (abnormal excessive or synchronous neuronal activity in the brain)

20-29:

Urinary tract disorder
Cholecystitis chronic (long lasting infection of gallbladder)
Erythema (redness of the skin)
Eye haemorrhage (bleeding in the eye)
Injection site erythema (redness at injection site)
Injection site mass
Injection site pain
Injection site pruritus (severe itching at injection site)
Injury
Oedema peripheral (superficial swelling)

30-39:

Abdominal distension
Cognitive disorder (mental health disorders affects learning, memory, perception, and problem solving)
Fatigue (feeling of tiredness)
Injury
Nausea (feeling of having an urge to vomit)
Pulmonary embolism (blockage of the main artery of the lung)
Thrombophlebitis superficial (swelling (inflammation) of a superficial vein caused by a blood clot)
Abdominal pain
Amnesia (deficit in memory caused by brain damage, disease, or psychological trauma)
Aphasia (damage to the parts of the brain that control language)

40-49:

Fatigue (feeling of tiredness)
Abdominal discomfort
Abdominal pain upper
Hodgkin's disease (cancer originating from white blood cells)
Infusion related reaction
Pyrexia (fever)
Chills (felling of cold)
Cholecystitis chronic (long lasting infection of gallbladder)
Cholelithiasis (the presence or formation of gallstones in the gallbladder or bile ducts)
Chronic kidney disease

50-59:

Grand mal convulsion (a type of generalized seizure that affects the entire brain)
Haemodynamic instability (disturbances in the blood movement in our body)
Hepatic failure (liver failure)
Hypotension (abnormally low blood pressure)
Lethargy (tiredness)
Mental disorder (a psychological term for a mental or behavioural pattern or anomaly that causes distress or disability)
Pancreatitis chronic (chronic inflammation of pancreas)
Pneumonia aspiration (bronchopneumonia that develops due to the entrance of foreign materials into the bronchial tree)
Renal tubular necrosis (death of kidney tubules)
Sepsis (a severe blood infection that can lead to organ failure and death)

60+:

Drug ineffective
Nasopharyngitis (inflammation of the nasopharynx)

What are the existing conditions these people have? *

Narcolepsy (brain's inability to regulate sleep-wake cycles normally): 19 people, 22.62%
Multiple Sclerosis (a nervous system disease that affects your brain and spinal cord. it damages the myelin sheath): 12 people, 14.29%
Cataplexy (loss of muscle tone accompanied by full conscious awareness): 9 people, 10.71%
Rheumatoid Arthritis (a chronic progressive disease causing inflammation in the joints): 7 people, 8.33%
Acne (skin problems that cause pimples): 7 people, 8.33%
Nausea (feeling of having an urge to vomit): 6 people, 7.14%
Premenstrual Syndrome: 5 people, 5.95%

* Approximation only. Some reports may have incomplete information.

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