Trulance and Acetaminophen drug interactions - a phase IV clinical study of FDA data

Summary:

Drug interactions are reported among people who take Trulance (plecanatide) and Acetaminophen (acetaminophen). Common drug interactions include pulmonary embolism among females and abdominal pain upper among males.

The phase IV clinical study analyzes what interactions people have when they take Trulance and Acetaminophen. It is created by eHealthMe based on reports of 73 people who take the same drugs from the FDA, and is updated regularly.

What is Trulance?

Trulance has active ingredients of plecanatide. eHealthMe is studying from 1,746 Trulance users. Check the latest studies of Trulance.

What is Acetaminophen?

Acetaminophen has active ingredients of acetaminophen. It is often used in pain. eHealthMe is studying from 183,078 Acetaminophen users. Check the latest studies of Acetaminophen.

eHealthMe: drug outcomes in the real world

eHealthMe runs one of the largest post-marketing drug safety studies in the world. We study millions of patients and 5,000 more each day. Our data-driven phase IV clinical trials have been referenced on 800+ peer-reviewed medical publications including The Lancet, Mayo Clinic Proceedings, and Nature. Tools to study our phase IV findings are available to the public, anonymous and free >>>.

On Sep, 02, 2026

73 people who take Trulance and Acetaminophen together, and have interactions are studied.

Trulance and Acetaminophen drug interactions.

What are the common drug interactions of Trulance and Acetaminophen, by gender? *:

female:

Pulmonary embolism (blockage of the main artery of the lung)
Renal impairment (severely reduced kidney function)
Speech disorder
Fall
Sinusitis (inflammation of sinus)
Fatigue (feeling of tiredness)
Weight decreased
Rash
Dizziness
Urinary tract infection

male:

Abdominal pain upper
Cardiac failure congestive
Infection
Injection site discharge
Injection site pain
Intestinal obstruction
Intussusception
Neuralgia (pain in one or more nerves)
Oedema (fluid collection in tissue)
Sepsis (a severe blood infection that can lead to organ failure and death)

What are the common drug interactions of Trulance and Acetaminophen, by age (0-1 to 60+)? *:

0-1:

n/a

2-9:

n/a

10-19:

n/a

20-29:

n/a

30-39:

Fall
Monoplegia (a paralysis of a single limb)
Urinary tract infection
Abdominal infection
Anaphylactic reaction (serious allergic reaction)
Back disorder
Cardiac failure
Dyspnoea (difficult or laboured respiration)
Gait disturbance
Infusion site extravasation (flow of (blood or lymph) from infusion site)

40-49:

Arthralgia (joint pain)
Asthma
Dermatitis contact (skin reaction (dermatitis) resulting from exposure to allergens)
Device occlusion
Dizziness
Ear congestion
Fall
Fatigue (feeling of tiredness)
Hereditary angioedema (recurrent episodes of severe swelling)
Hypotension (abnormally low blood pressure)

50-59:

Eating disorder
Genital discomfort
Inflammation
Pneumonia
Abdominal distension
Dizziness
Heart rate increased
Hernia (hernia happens when part of an internal organ or tissue bulges through a weak area of muscle)
Osteoarthritis (a joint disease caused by cartilage loss in a joint)
Rash

60+:

Infusion site erythema (reddening of the skin at infusion site)
Rash
Pruritus (severe itching of the skin)
Abdominal pain upper
Blood pressure increased
Diarrhoea
Dyspnoea (difficult or laboured respiration)
Skin cancer
Throat irritation
Chronic kidney disease

What are the existing conditions these people have? *

Immunodeficiency Common Variable: 45 people, 61.64%
Immune System Disorder: 6 people, 8.22%
B-Lymphocyte Abnormalities (abnormal population of b lymphocytes in the blood, bone marrow, or tissues): 6 people, 8.22%
Gastroesophageal Reflux Disease (a condition in which stomach contents leak backward from the stomach into the oesophagus): 5 people, 6.85%
Polyneuropathy (neurological disorder that occurs when many peripheral nerves throughout the body malfunction simultaneously): 4 people, 5.48%
Neuropathy Peripheral (surface nerve damage): 4 people, 5.48%
Asthma: 4 people, 5.48%
Affective Disorder (mental disorder): 4 people, 5.48%

* Approximation only. Some reports may have incomplete information.

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