Tylenol w/ codeine and Effexor xr drug interactions - a phase IV clinical study of FDA data

Summary:

Drug interactions are reported among people who take Tylenol w/ codeine (acetaminophen; codeine phosphate) and Effexor xr (venlafaxine hydrochloride). Common drug interactions include mobility decreased among females and nausea among males.

The phase IV clinical study analyzes what interactions people have when they take Tylenol w/ codeine and Effexor xr. It is created by eHealthMe based on reports of 54 people who take the same drugs from the FDA, and is updated regularly.

What is Tylenol w/ codeine?

Tylenol w/ codeine has active ingredients of acetaminophen; codeine phosphate. It is often used in pain. eHealthMe is studying from 8,107 Tylenol w/ codeine users. Check the latest studies of Tylenol w/ codeine.

What is Effexor xr?

Effexor xr has active ingredients of venlafaxine hydrochloride. It is often used in depression. eHealthMe is studying from 35,233 Effexor xr users. Check the latest studies of Effexor xr.

On Jul, 10, 2026

54 people who take Tylenol w/ codeine and Effexor xr together, and have interactions are studied.

Tylenol w/ codeine and Effexor xr drug interactions.

What are the common drug interactions of Tylenol W/ Codeine and Effexor Xr, by gender? *:

female:

Mobility decreased (ability to move is reduced)
Nausea (feeling of having an urge to vomit)
Neck pain
Nephrogenic systemic fibrosis (involves fibrosis of skin, joints, eyes due to kidney disease)
Ovarian cyst (fluid filled sac of the ovary)
Palpitations (feelings or sensations that your heart is pounding or racing)
Skin hypopigmentation (loss of skin colour)
Skin ulcer
Suicide attempt
Acne (skin problems that cause pimples)

male:

Nausea (feeling of having an urge to vomit)
Vomiting
Acute respiratory failure
Blood pressure increased
Cardiac valve replacement complication
Cerebrovascular accident (sudden death of some brain cells due to lack of oxygen when the blood flow to the brain is impaired by blockage or rupture)
Constipation
Diarrhoea
Drug hypersensitivity
Ejection fraction decreased (systolic heart failure)

What are the common drug interactions of Tylenol W/ Codeine and Effexor Xr, by age (0-1 to 60+)? *:

0-1:

n/a

2-9:

n/a

10-19:

n/a

20-29:

Cerebral infarction (less blood supply to brain resulting tissue damage)
Coma (state of unconsciousness lasting more than six hours)
Cyanosis (lack of oxygen in body leads to blue appearance of skin ,mucous membrane nails)
Drug ineffective
Dyspnoea (difficult or laboured respiration)
Hypoxic-ischaemic encephalopathy (a condition that occurs when the entire brain is deprived of an adequate oxygen supply, but the deprivation isn't total)
Renal failure (kidney dysfunction)
Respiratory failure (inadequate gas exchange by the respiratory system)
Rhabdomyolysis (a condition in which damaged skeletal muscle tissue breaks down)
Suicide attempt

30-39:

Weight increased
Amenorrhoea (absence of a menstrual period in a woman of reproductive age)
Carpal tunnel syndrome (nerve compression at wrist results numbness weakness, pain , swelling)
Central obesity (belly fat)
Chest pain
Diabetes mellitus non-insulin-dependent
Dyspnoea (difficult or laboured respiration)
General physical condition
Headache (pain in head)
Hypoglycaemia (deficiency of glucose in the bloodstream)

40-49:

Pain in extremity
Skin discolouration (change of skin colour)
Muscle spasms (muscle contraction)
Deep vein thrombosis (blood clot in a major vein that usually develops in the legs and/or pelvis)
Paraesthesia (sensation of tingling, tickling, prickling, pricking, or burning of a person's skin with no apparent long-term physical effect)
Abortion induced (medically referred abortion)
Amnesia (deficit in memory caused by brain damage, disease, or psychological trauma)
Arrhythmia (irregular heartbeat)
Arthralgia (joint pain)
Autonomic nervous system imbalance (autonomic nervous system is of net equal emphasis)

50-59:

Impaired driving ability
Impaired work ability
Lower gastrointestinal haemorrhage (bleeding in the large intestine, rectum, or anus is called lower gi bleeding)
Menorrhagia (an abnormally heavy bleeding and prolonged menstrual period at regular intervals)
Myalgia (muscle pain)
Myositis (inflammation of the muscles)
Panic disorder
Perirectal abscess
Sinusitis (inflammation of sinus)
Supraventricular extrasystoles (premature electrical impulse in the heart, generated above the level of the ventricle)

60+:

Drug ineffective
Epistaxis (bleed from the nose)
Haematochezia (passage of stools containing blood)
Heart rate irregular
Idiopathic thrombocytopenic purpura (bleeding disorder in which the immune system destroys platelets, which are necessary for normal blood clotting)
Impaired healing
Increased tendency to bruise (increased tendency to injure the underlying soft tissue or bone)
Myocardial infarction (destruction of heart tissue resulting from obstruction of the blood supply to the heart muscle)
Nausea (feeling of having an urge to vomit)
Thrombocytopenia (decrease of platelets in blood)

What are the existing conditions these people have? *

Stress And Anxiety: 5 people, 9.26%
Migraine (headache): 3 people, 5.56%
Joint Pain: 3 people, 5.56%
Arthritis (form of joint disorder that involves inflammation of one or more joints): 3 people, 5.56%

* Approximation only. Some reports may have incomplete information.

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