Tylenol w/ codeine and Lamictal drug interactions - a phase IV clinical study of FDA data

Summary:

Drug interactions are reported among people who take Tylenol w/ codeine (acetaminophen; codeine phosphate) and Lamictal (lamotrigine). Common drug interactions include confusional state among females and constipation among males.

The phase IV clinical study analyzes what interactions people have when they take Tylenol w/ codeine and Lamictal. It is created by eHealthMe based on reports of 78 people who take the same drugs from the FDA, and is updated regularly.

What is Tylenol w/ codeine?

Tylenol w/ codeine has active ingredients of acetaminophen; codeine phosphate. It is often used in pain. eHealthMe is studying from 8,107 Tylenol w/ codeine users. Check the latest studies of Tylenol w/ codeine.

What is Lamictal?

Lamictal has active ingredients of lamotrigine. It is often used in bipolar disorder. eHealthMe is studying from 82,626 Lamictal users. Check the latest studies of Lamictal.

On Jul, 13, 2026

78 people who take Tylenol w/ codeine and Lamictal together, and have interactions are studied.

Tylenol w/ codeine and Lamictal drug interactions.

What are the common drug interactions of Tylenol W/ Codeine and Lamictal, by gender? *:

female:

Confusional state
Emotional distress
Hypoaesthesia (reduced sense of touch or sensation)
Malaise (a feeling of general discomfort or uneasiness)
Radiculitis (inflammation of the spinal nerve roots)
Breast cancer recurrent
Decreased interest
Hepatic steatosis (fatty liver disease)
Hepatitis c
Hiatus hernia (hernia resulting from the protrusion of part of the stomach through the diaphragm)

male:

Constipation
Mania (a state of abnormally elevated or irritable mood)
Diarrhoea haemorrhagic (bloody diarrhoea)
Drug ineffective
Haemorrhoids (a swollen vein or group of veins in the region of the anus)
Heart rate increased
Hepatitis acute
Hypoaesthesia (reduced sense of touch or sensation)
Insomnia (sleeplessness)
Nausea (feeling of having an urge to vomit)

What are the common drug interactions of Tylenol W/ Codeine and Lamictal, by age (0-1 to 60+)? *:

0-1:

n/a

2-9:

n/a

10-19:

n/a

20-29:

Rash pruritic (redness with itching)
Cough
Deep vein thrombosis (blood clot in a major vein that usually develops in the legs and/or pelvis)
Ill-defined disorder
Oral pain
Oropharyngeal pain
Pharyngitis streptococcal (inflammation of the pharynx caused by infection from. streptococcus)
Pulmonary embolism (blockage of the main artery of the lung)
Pyrexia (fever)
Rash

30-39:

Stevens-johnson syndrome (an immune-complex-mediated hypersensitivity disorder. it ranges from mild skin and mucous membrane lesions to a severe)
Blindness
Hypersensitivity
Injury
Mucous membrane disorder (disease of mucous membrane)
Toxic epidermal necrolysis (a rare, life-threatening skin condition that is usually caused by a reaction to drugs causes wide spread skin destruction)
Muscle spasms (muscle contraction)
Pyrexia (fever)
Rash
Vaginal obstruction

40-49:

Abdominal pain
Agitation (state of anxiety or nervous excitement)
Angina pectoris (chest pain due to ischemia of the heart muscle)
Arthralgia (joint pain)
Constipation
Depression
Grand mal convulsion (a type of generalized seizure that affects the entire brain)
Haemorrhoids (a swollen vein or group of veins in the region of the anus)
Headache (pain in head)
Heart rate increased

50-59:

Eye inflammation
Fall
Gastritis (inflammation of stomach)
Gastrooesophageal reflux disease (stomach contents (food or liquid) leak backwards from the stomach into the oesophagus)
Hernia pain
Hydrocephalus (water on the brain)
Hyperlipidaemia (presence of excess lipids in the blood)
Hypersensitivity
Hypertonia (abnormal increase in muscle tension and a reduced ability of a muscle to stretch)
Impaired driving ability

60+:

Anorexia (eating disorder characterized by immoderate food restriction and irrational fear of gaining weight)
Arthralgia (joint pain)
Jaw disorder (jaw disease)
Mania (a state of abnormally elevated or irritable mood)
Rash
Social avoidant behaviour (avoiding social connection a personality disorder)
Tardive dyskinesia (a disorder that involves involuntary movements)
Tremor (trembling or shaking movements in one or more parts of your body)
Upper limb fracture
Weight decreased

What are the existing conditions these people have? *

Sleep Disorder: 8 people, 10.26%
Resorption Bone Increased: 8 people, 10.26%
Insomnia (sleeplessness): 8 people, 10.26%
Depression: 5 people, 6.41%

* Approximation only. Some reports may have incomplete information.

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