Valium and Protopic drug interactions - a phase IV clinical study of FDA data

Summary:

Drug interactions are reported among people who take Valium (diazepam) and Protopic (tacrolimus). Common drug interactions include arthralgia among females and abdominal pain upper among males.

The phase IV clinical study analyzes what interactions people have when they take Valium and Protopic. It is created by eHealthMe based on reports of 29 people who take the same drugs from the FDA, and is updated regularly.

What is Valium?

Valium has active ingredients of diazepam. It is often used in stress and anxiety. eHealthMe is studying from 48,647 Valium users. Check the latest studies of Valium.

What is Protopic?

Protopic has active ingredients of tacrolimus. It is often used in eczema. eHealthMe is studying from 5,403 Protopic users. Check the latest studies of Protopic.

On Jul, 13, 2026

29 people who take Valium and Protopic together, and have interactions are studied.

What are the common drug interactions of Valium and Protopic, by gender? *:

female:

Arthralgia (joint pain)
Basal cell carcinoma (a skin cancer, it rarely metastasizes or kills)
Blood sodium decreased
Joint swelling
Pneumonia
Pyoderma gangrenosum (ulcerating condition of skin that results in heaped borders with a typical appearance)
Rash
Therapeutic response decreased (less preventive response)
Thirst
Weight decreased

male:

Abdominal pain upper
Confusional state
Vision blurred
Agitation (state of anxiety or nervous excitement)
Anal pruritus (anal itching)
Cough
Drug ineffective
Drug withdrawal syndrome (interfere with normal social, occupational, or other functioning. are not due to another medical condition, drug use, or discontinuation)
Dystonia (abnormal muscle tone)
Genital discomfort

What are the common drug interactions of Valium and Protopic, by age (0-1 to 60+)? *:

0-1:

n/a

2-9:

Agitation (state of anxiety or nervous excitement)
Drug withdrawal syndrome (interfere with normal social, occupational, or other functioning. are not due to another medical condition, drug use, or discontinuation)
Dystonia (abnormal muscle tone)
Hypertonia (abnormal increase in muscle tension and a reduced ability of a muscle to stretch)
Insomnia (sleeplessness)
Tremor (trembling or shaking movements in one or more parts of your body)

10-19:

Abdominal pain upper
Neck pain
Vision blurred

20-29:

n/a

30-39:

n/a

40-49:

Thyroid cancer
Hypersensitivity
Low density lipoprotein increased (cholesterol increased in blood)
Rash generalised (rash on most of body parts)
Swelling

50-59:

Joint swelling
Arthralgia (joint pain)
Basal cell carcinoma (a skin cancer, it rarely metastasizes or kills)
Blood sodium decreased
Pneumonia
Pyoderma gangrenosum (ulcerating condition of skin that results in heaped borders with a typical appearance)
Rash
Therapeutic response decreased (less preventive response)
Thirst
Weight decreased

60+:

B-cell lymphoma (blood cancer affecting b cells)
Drug eruption (adverse drug reaction of the skin)
Glucose urine present
Lupus-like syndrome (a disease symptom matches with lupus an immune disease)
Mobility decreased (ability to move is reduced)
Rash maculo-papular (red area on the skin that is covered with small confluent bumps)
Renal failure chronic (long lasting kidney dysfunction)
Stress urinary incontinence (leak urine with things like coughing, sneezing or exercise)
Testicular pain (pain in testes)
Hypercalcaemia (elevated calcium (ca+) level in the blood)

What are the existing conditions these people have? *

Dermatomyositis (inflammation of the skin and underlying muscle tissue, typically occurring as an autoimmune condition or associated with internal cancer): 7 people, 24.14%
Rheumatoid Arthritis (a chronic progressive disease causing inflammation in the joints): 6 people, 20.69%
Polyarthritis (arthritis which involves 5 or more joints simultaneously): 5 people, 17.24%
Menopausal Symptoms: 5 people, 17.24%
Juvenile Arthritis (arthritis-related condition that develops in children or teenagers): 5 people, 17.24%
Dry Skin: 3 people, 10.34%
Diarrhea: 3 people, 10.34%
Crohn's Disease (a condition that causes inflammation of the gastrointestinal tract): 3 people, 10.34%
Constipation: 3 people, 10.34%
Psoriasis (immune-mediated disease that affects the skin): 2 people, 6.90%

* Approximation only. Some reports may have incomplete information.

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