Vimovo and Nucynta er drug interactions - a phase IV clinical study of FDA data

Summary:

Drug interactions are reported among people who take Vimovo (esomeprazole magnesium; naproxen) and Nucynta er (tapentadol hydrochloride). Common drug interactions include drug administration error among females and decreased appetite among males.

The phase IV clinical study analyzes what interactions people have when they take Vimovo and Nucynta er. It is created by eHealthMe based on reports of 17 people who take the same drugs from the FDA, and is updated regularly.

What is Vimovo?

Vimovo has active ingredients of esomeprazole magnesium; naproxen. It is often used in osteoarthritis. eHealthMe is studying from 9,608 Vimovo users. Check the latest studies of Vimovo.

What is Nucynta er?

Nucynta er has active ingredients of tapentadol hydrochloride. It is often used in pain. eHealthMe is studying from 2,508 Nucynta er users. Check the latest studies of Nucynta er.

On Jul, 09, 2026

17 people who take Vimovo and Nucynta er together, and have interactions are studied.

Vimovo and Nucynta er drug interactions.

What are the common drug interactions of Vimovo and Nucynta Er, by gender? *:

female:

Drug administration error
Feeling hot
Palpitations (feelings or sensations that your heart is pounding or racing)
Adverse event
Gait disturbance
Heart rate increased
Cardiac flutter (abnormal heart rhythm)
Anaphylactic reaction (serious allergic reaction)
Cough
Demyelination (loss of the myelin covering of some nerve fibres resulting in their impaired function)

male:

Decreased appetite
Weight decreased
Depression
Suicide attempt

What are the common drug interactions of Vimovo and Nucynta Er, by age (0-1 to 60+)? *:

0-1:

n/a

2-9:

n/a

10-19:

n/a

20-29:

Amnesia (deficit in memory caused by brain damage, disease, or psychological trauma)
Disturbance in attention
Euphoric mood (excessively happy but may become angry or irritable)
Sleep disorder

30-39:

n/a

40-49:

Hypertension (high blood pressure)
Poor quality sleep
Tremor (trembling or shaking movements in one or more parts of your body)
Chest pain
Drug administration error
Feeling hot
Palpitations (feelings or sensations that your heart is pounding or racing)
Adverse event
Gait disturbance
Heart rate increased

50-59:

Decreased appetite
Depression
Weight decreased
Abdominal distension
Abdominal pain upper
Eating disorder
Malaise (a feeling of general discomfort or uneasiness)

60+:

Death

What are the existing conditions these people have? *

Sleep Disorder: 9 people, 52.94%
Swelling: 7 people, 41.18%
Gastric Disorder (disease of stomach): 7 people, 41.18%
Back Pain: 7 people, 41.18%
Multiple Myeloma (cancer of the plasma cells): 4 people, 23.53%
Rheumatoid Arthritis (a chronic progressive disease causing inflammation in the joints): 2 people, 11.76%
Hypersensitivity: 2 people, 11.76%
Fibromyalgia (a long-term condition which causes pain all over the body): 1 person, 5.88%
Breakthrough Pain: 1 person, 5.88%

* Approximation only. Some reports may have incomplete information.

Do you take Vimovo and Nucynta er?

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