Xeljanz and Roflumilast drug interactions - a phase IV clinical study of FDA data

Summary:

Drug interactions are reported among people who take Xeljanz (tofacitinib citrate) and Roflumilast (roflumilast). Common drug interactions include bedridden among females and inflammatory bowel disease among males.

The phase IV clinical study analyzes what interactions people have when they take Xeljanz and Roflumilast. It is created by eHealthMe based on reports of 14 people who take the same drugs from the FDA, and is updated regularly.

What is Xeljanz?

Xeljanz has active ingredients of tofacitinib citrate. It is often used in rheumatoid arthritis. eHealthMe is studying from 239,081 Xeljanz users. Check the latest studies of Xeljanz.

What is Roflumilast?

Roflumilast has active ingredients of roflumilast. eHealthMe is studying from 2,247 Roflumilast users. Check the latest studies of Roflumilast.

eHealthMe: drug outcomes in the real world

eHealthMe runs one of the largest post-marketing drug safety studies in the world. We study millions of patients and 5,000 more each day. Our data-driven phase IV clinical trials have been referenced on 800+ peer-reviewed medical publications including The Lancet, Mayo Clinic Proceedings, and Nature. Tools to study our phase IV findings are available to the public, anonymous and free >>>.

On Aug, 15, 2026

14 people who take Xeljanz and Roflumilast together, and have interactions are studied.

Xeljanz and Roflumilast drug interactions.

What are the common drug interactions of Xeljanz and Roflumilast, by gender? *:

female:

Bedridden
Brain oedema (excess accumulation of fluid in the intracellular or extracellular spaces of the brain)
Cardiac arrest
Chronic obstructive pulmonary disease (a progressive disease that makes it hard to breathe)
Clostridium difficile colitis (inflammation of colon by clostridium difficile bacteria infection)
Colitis ulcerative (inflammation of colon with ulcer)
Confusional state
Dysphagia (a condition in which swallowing is difficult or painful)
Hyponatraemia (abnormally low level of sodium in the blood; associated with dehydration)
Ischaemic hepatitis (decreased blood supply to the liver resulting in injury to liver cells)

male:

Inflammatory bowel disease
Abdominal distension
Abdominal rigidity
Diarrhoea
Malaise (a feeling of general discomfort or uneasiness)
Nausea (feeling of having an urge to vomit)
Rectal haemorrhage (bleeding from anus)

What are the common drug interactions of Xeljanz and Roflumilast, by age (0-1 to 60+)? *:

0-1:

n/a

2-9:

n/a

10-19:

n/a

20-29:

Inflammatory bowel disease

30-39:

n/a

40-49:

n/a

50-59:

n/a

60+:

Acute respiratory distress syndrome
Anaemia (lack of blood)
Dysphagia (a condition in which swallowing is difficult or painful)
Hyponatraemia (abnormally low level of sodium in the blood; associated with dehydration)
Ischaemic hepatitis (decreased blood supply to the liver resulting in injury to liver cells)
Lumbar vertebral fracture
Malaise (a feeling of general discomfort or uneasiness)
Meningoencephalitis herpetic (inflammation of the brain and meninges by virus)
Mental status changes (general changes in brain function, such as confusion, amnesia (memory loss), loss of alertness, loss of orientation)
Nausea (feeling of having an urge to vomit)

What are the existing conditions these people have? *

Ulcerative Colitis (inflammatory bowel disease (ibd). it causes swelling, ulcerations, and loss of function of the large intestine): 11 people, 78.57%
Nausea (feeling of having an urge to vomit): 11 people, 78.57%
Wheezing (a high-pitched whistling sound made while you breath): 1 person, 7.14%
Sleep Disorder: 1 person, 7.14%
Pain: 1 person, 7.14%
Dyspnea (difficult or laboured breathing): 1 person, 7.14%
Crohn's Disease (a condition that causes inflammation of the gastrointestinal tract): 1 person, 7.14%

* Approximation only. Some reports may have incomplete information.

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