Xifaxan and Oxycontin drug interactions - a phase IV clinical study of FDA data

Summary:

Drug interactions are reported among people who take Xifaxan (rifaximin) and Oxycontin (oxycodone hydrochloride). Common drug interactions include ammonia increased among females and chronic kidney disease among males.

The phase IV clinical study analyzes what interactions people have when they take Xifaxan and Oxycontin. It is created by eHealthMe based on reports of 85 people who take the same drugs from the FDA, and is updated regularly.

What is Xifaxan?

Xifaxan has active ingredients of rifaximin. It is often used in irritable bowel syndrome. eHealthMe is studying from 16,609 Xifaxan users. Check the latest studies of Xifaxan.

What is Oxycontin?

Oxycontin has active ingredients of oxycodone hydrochloride. It is often used in pain. eHealthMe is studying from 212,533 Oxycontin users. Check the latest studies of Oxycontin.

On Jul, 10, 2026

85 people who take Xifaxan and Oxycontin together, and have interactions are studied.

Xifaxan and Oxycontin drug interactions.

What are the common drug interactions of Xifaxan and Oxycontin, by gender? *:

female:

Ammonia increased
Death
Drug effect decreased
Fatigue (feeling of tiredness)
Gastritis (inflammation of stomach)
Gastrointestinal haemorrhage (bleeding gastrointestinal tract)
Hypoxia (low oxygen in tissues)
Lung disorder (lung disease)
Multi-organ failure (multisystem organ failure)
Oesophageal haemorrhage (bleeding from oesophagus)

male:

Chronic kidney disease
Sepsis (a severe blood infection that can lead to organ failure and death)
Death
Peripheral swelling
Renal failure (kidney dysfunction)
Abdominal discomfort
Crohn's disease (a condition that causes inflammation of the gastrointestinal tract)
Abdominal distension
Abdominal pain
Ammonia increased

What are the common drug interactions of Xifaxan and Oxycontin, by age (0-1 to 60+)? *:

0-1:

n/a

2-9:

n/a

10-19:

n/a

20-29:

n/a

30-39:

Viral infection
Ammonia increased
Cystitis (inflammation of the wall of the bladder)
Dyspnoea (difficult or laboured respiration)
Vomiting
Alanine aminotransferase increased
Anaemia (lack of blood)
Bacteraemia (presence of bacteria in the blood)
Blood glucose increased
Decreased appetite

40-49:

Crohn's disease (a condition that causes inflammation of the gastrointestinal tract)
Drug ineffective
Fall
Femur fracture
Hip fracture
Liver disorder (liver diseases)
Loss of consciousness
Pelvic fracture
Rib fracture
Skull fracture

50-59:

Multiple fractures
Nausea (feeling of having an urge to vomit)
Oral infection
Pleural effusion (water on the lungs)
Pulmonary hypertension (increase in blood pressure in the lung artery)
Sepsis (a severe blood infection that can lead to organ failure and death)
Staphylococcal infection (an infection with staphylococcus bacteria)
White blood cell count increased
Chronic kidney disease
Anhedonia (inability to experience pleasure from activities usually found enjoyable)

60+:

Cellulitis (infection under the skin)
Sepsis (a severe blood infection that can lead to organ failure and death)
Hepatic failure (liver failure)
Nausea (feeling of having an urge to vomit)
Productive cough
Renal failure (kidney dysfunction)
Vomiting
Weight decreased
Blood glucose decreased
Cholecystitis (infection of gallbladder)

What are the existing conditions these people have? *

Gastroesophageal Reflux Disease (a condition in which stomach contents leak backward from the stomach into the oesophagus): 17 people, 20.00%
High Blood Pressure: 14 people, 16.47%
Nausea (feeling of having an urge to vomit): 11 people, 12.94%
Infection: 10 people, 11.76%
Stress And Anxiety: 10 people, 11.76%
Constipation: 9 people, 10.59%
Depression: 9 people, 10.59%
Indigestion: 8 people, 9.41%
Neuralgia (pain in one or more nerves): 8 people, 9.41%
Hypersensitivity: 7 people, 8.24%

* Approximation only. Some reports may have incomplete information.

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