Ziac and Zanaflex drug interactions - a phase IV clinical study of FDA data

Summary:

Drug interactions are reported among people who take Ziac (bisoprolol fumarate; hydrochlorothiazide) and Zanaflex (tizanidine hydrochloride). Common drug interactions include influenza like illness among females and depression among males.

The phase IV clinical study analyzes what interactions people have when they take Ziac and Zanaflex. It is created by eHealthMe based on reports of 56 people who take the same drugs from the FDA, and is updated regularly.

What is Ziac?

Ziac has active ingredients of bisoprolol fumarate; hydrochlorothiazide. It is often used in high blood pressure. eHealthMe is studying from 4,451 Ziac users. Check the latest studies of Ziac.

What is Zanaflex?

Zanaflex has active ingredients of tizanidine hydrochloride. It is often used in muscle spasms. eHealthMe is studying from 17,476 Zanaflex users. Check the latest studies of Zanaflex.

On Jul, 24, 2026

56 people who take Ziac and Zanaflex together, and have interactions are studied.

What are the common drug interactions of Ziac and Zanaflex, by gender? *:

female:

Influenza like illness
Fall
Hypersensitivity
Infection
Rash
Renal disorder (kidney disease)
Skin lesion
Arthralgia (joint pain)
Diabetes mellitus (diabetes, caused by a deficiency of the pancreatic hormone insulin)
Dizziness

male:

Depression
Headache (pain in head)
Drug withdrawal syndrome (interfere with normal social, occupational, or other functioning. are not due to another medical condition, drug use, or discontinuation)
Sinusitis (inflammation of sinus)
Asthenia (weakness)
Drug abuser
Fatigue (feeling of tiredness)
Hypoaesthesia (reduced sense of touch or sensation)
Hyponatraemia (abnormally low level of sodium in the blood; associated with dehydration)
Hypovolaemia (a decreased volume of circulating blood in the body)

What are the common drug interactions of Ziac and Zanaflex, by age (0-1 to 60+)? *:

0-1:

n/a

2-9:

n/a

10-19:

n/a

20-29:

n/a

30-39:

Drug screen positive
Weight decreased

40-49:

Weight decreased
Joint swelling
Lethargy (tiredness)
Panic attack
Sexual dysfunction (difficulty experienced by an individual or a couple during any stage of a normal sexual activity)
Toothache (tooth pain)
Urinary hesitation (difficulty in beginning the flow of urine)
Abscess limb (limb infection)
Adjustment disorder
Alcoholism (problems with alcohol)

50-59:

Influenza like illness
Myocardial infarction (destruction of heart tissue resulting from obstruction of the blood supply to the heart muscle)
Acute coronary syndrome (acute chest pain and other symptoms that happen because the heart does not get blood)
Emotional distress
Gastritis (inflammation of stomach)
Hypersensitivity
Infection
Multiple sclerosis relapse (reoccurrence of a nervous system disease that affects your brain and spinal cord. it damages the myelin sheath)
Rash
Renal disorder (kidney disease)

60+:

Acute respiratory distress syndrome
Anaemia (lack of blood)
Chronic obstructive pulmonary disease (a progressive disease that makes it hard to breathe)
Ileus (a painful obstruction of the ileum or other part of the intestine)
Legionella infection (a lung infection caused by bacteria of the species legionella)
Pneumonia
Septic shock (shock due to blood infection)
Staphylococcal infection (an infection with staphylococcus bacteria)

What are the existing conditions these people have? *

Multiple Sclerosis (a nervous system disease that affects your brain and spinal cord. it damages the myelin sheath): 10 people, 17.86%
Depression: 8 people, 14.29%
Pain: 6 people, 10.71%
Gastroesophageal Reflux Disease (a condition in which stomach contents leak backward from the stomach into the oesophagus): 6 people, 10.71%
Relapsing-Remitting Multiple Sclerosis (reoccurrence of an inflammatory disease in which the insulating covers of nerve cells in the brain and spinal cord are damaged): 5 people, 8.93%
Chronic Myeloid Leukaemia (long lasting type of cancer that starts in the blood-forming cells of the bone marrow and invades the blood): 5 people, 8.93%
Stress And Anxiety: 4 people, 7.14%
Rheumatoid Arthritis (a chronic progressive disease causing inflammation in the joints): 3 people, 5.36%
Nausea (feeling of having an urge to vomit): 3 people, 5.36%
Joint Pain: 3 people, 5.36%

* Approximation only. Some reports may have incomplete information.

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