Zonegran and Naproxen drug interactions - a phase IV clinical study of FDA data

Summary:

Drug interactions are reported among people who take Zonegran (zonisamide) and Naproxen (naproxen). Common drug interactions include hypoaesthesia among females and obsessive-compulsive disorder among males.

The phase IV clinical study analyzes what interactions people have when they take Zonegran and Naproxen. It is created by eHealthMe based on reports of 38 people who take the same drugs from the FDA, and is updated regularly.

What is Zonegran?

Zonegran has active ingredients of zonisamide. It is often used in epilepsy. eHealthMe is studying from 6,211 Zonegran users. Check the latest studies of Zonegran.

What is Naproxen?

Naproxen has active ingredients of naproxen. It is often used in pain. eHealthMe is studying from 72,033 Naproxen users. Check the latest studies of Naproxen.

eHealthMe: drug outcomes in the real world

eHealthMe runs one of the largest post-marketing drug safety studies in the world. We study millions of patients and 5,000 more each day. Our data-driven phase IV clinical trials have been referenced on 800+ peer-reviewed medical publications including The Lancet, Mayo Clinic Proceedings, and Nature. Tools to study our phase IV findings are available to the public, anonymous and free >>>.

On Aug, 23, 2026

38 people who take Zonegran and Naproxen together, and have interactions are studied.

Zonegran and Naproxen drug interactions.

What are the common drug interactions of Zonegran and Naproxen, by gender? *:

female:

Hypoaesthesia (reduced sense of touch or sensation)
Hypoglycaemia (deficiency of glucose in the bloodstream)
Infection
Intervertebral disc space narrowing (spinal disc space narrowing)
Joint injury
Leukopenia (less number of white blood cells in blood)
Mania (a state of abnormally elevated or irritable mood)
Menstruation delayed (late menstruation cycle)
Muscle twitching
Myocardial infarction (destruction of heart tissue resulting from obstruction of the blood supply to the heart muscle)

male:

Obsessive-compulsive disorder (an anxiety disorder characterized by intrusive thoughts that produce uneasiness, apprehension, fear, or worry;)
Actinic keratosis (skin disease due to sun exposure)
Lumbar radiculopathy (radicular pain in the low back and legs)
Melanocytic naevus (a type of lesion that contains nevus cells (a type of melanocyte))
Neuropathy peripheral (surface nerve damage)
Paraesthesia (sensation of tingling, tickling, prickling, pricking, or burning of a person's skin with no apparent long-term physical effect)
Polyp
Rectal haemorrhage (bleeding from anus)
Telangiectasia (small dilated blood vessels near the surface of the skin)
Blood cholesterol increased

What are the common drug interactions of Zonegran and Naproxen, by age (0-1 to 60+)? *:

0-1:

n/a

2-9:

n/a

10-19:

Ear infection
Eye infection
Irritability
Pharyngitis (inflammation of the pharynx, causing a sore throat)
Photosensitivity reaction
Pregnancy with contraceptive device
Rhinitis (a medical term for irritation and inflammation of the mucous membrane inside the nose)
Sinusitis (inflammation of sinus)
Swelling face
Amenorrhoea (absence of a menstrual period in a woman of reproductive age)

20-29:

Cardiac disorder
Type 1 diabetes mellitus
Abnormal behaviour
Aggression
Cardiac failure congestive
Crying
Depression
Diabetes mellitus (diabetes, caused by a deficiency of the pancreatic hormone insulin)
Dizziness
Headache (pain in head)

30-39:

Carpal tunnel syndrome (nerve compression at wrist results numbness weakness, pain , swelling)
Fatigue (feeling of tiredness)
Surgery

40-49:

Chronic kidney disease
Depression
Renal failure (kidney dysfunction)
Type 2 diabetes mellitus
Abnormal dreams
Amnesia (deficit in memory caused by brain damage, disease, or psychological trauma)
Arthralgia (joint pain)
Asthenia (weakness)
Blood cholesterol increased
Blood glucose increased

50-59:

Arthropathy
Drug hypersensitivity
Surgery
Vitamin b12 increased
Asthenia (weakness)
Autonomic neuropathy (malfunction of the autonomic nervous system (ans))
Cardiomegaly (increased size of heart than normal)
Dementia (madness)
Dry eye (lack of adequate tears)
Eye irritation

60+:

Agitation (state of anxiety or nervous excitement)
Diverticulitis (digestive disease which involves the formation of pouches (diverticula) within the bowel wall)
Pruritus (severe itching of the skin)
Restless legs syndrome (a powerful urge to move your legs)
Feeling cold
Feeling hot
Insomnia (sleeplessness)
Muscle spasms (muscle contraction)
Oedema (fluid collection in tissue)
Oedema peripheral (superficial swelling)

What are the existing conditions these people have? *

Narcolepsy (brain's inability to regulate sleep-wake cycles normally): 9 people, 23.68%
Stress And Anxiety: 5 people, 13.16%
Cataplexy (loss of muscle tone accompanied by full conscious awareness): 5 people, 13.16%
Restless Leg Syndrome (a powerful urge to move your legs): 4 people, 10.53%
Optic Neuritis (optic nerve inflammation): 4 people, 10.53%
Migraine (headache): 4 people, 10.53%
Affective Disorder (mental disorder): 4 people, 10.53%
Post-Traumatic Stress Disorder: 3 people, 7.89%
Major Depression (a mood state that goes well beyond temporarily feeling sad or blue. it is a serious medical illness that affects one's thoughts, feelings): 3 people, 7.89%
Sleep Disorder: 2 people, 5.26%

* Approximation only. Some reports may have incomplete information.

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