Zonegran and Simvastatin drug interactions - a phase IV clinical study of FDA data

Summary:

Drug interactions are reported among people who take Zonegran (zonisamide) and Simvastatin (simvastatin). Common drug interactions include pneumonia among females and neuropathy peripheral among males.

The phase IV clinical study analyzes what interactions people have when they take Zonegran and Simvastatin. It is created by eHealthMe based on reports of 79 people who take the same drugs from the FDA, and is updated regularly.

What is Zonegran?

Zonegran has active ingredients of zonisamide. It is often used in epilepsy. eHealthMe is studying from 6,211 Zonegran users. Check the latest studies of Zonegran.

What is Simvastatin?

Simvastatin has active ingredients of simvastatin. It is often used in high blood cholesterol. eHealthMe is studying from 256,969 Simvastatin users. Check the latest studies of Simvastatin.

On Jul, 26, 2026

79 people who take Zonegran and Simvastatin together, and have interactions are studied.

Zonegran and Simvastatin drug interactions.

What are the common drug interactions of Zonegran and Simvastatin, by gender? *:

female:

Pneumonia
Psychotic disorder
Skin lesion
Tendonitis (a condition that causes pain and swelling of tendons)
Wound infection staphylococcal
Abdominal distension
Abdominal pain
Blood glucose increased
Cataract (clouding of the lens inside the eye)
Cellulitis (infection under the skin)

male:

Neuropathy peripheral (surface nerve damage)
Obsessive-compulsive disorder (an anxiety disorder characterized by intrusive thoughts that produce uneasiness, apprehension, fear, or worry;)
Haemorrhoids (a swollen vein or group of veins in the region of the anus)
Lentigo (a small pigmented spot on the skin with a clearly-defined edge, surrounded by normal-appearing skin)
Lumbar radiculopathy (radicular pain in the low back and legs)
Melanocytic naevus (a type of lesion that contains nevus cells (a type of melanocyte))
Paraesthesia (sensation of tingling, tickling, prickling, pricking, or burning of a person's skin with no apparent long-term physical effect)
Polyp
Rectal haemorrhage (bleeding from anus)
Telangiectasia (small dilated blood vessels near the surface of the skin)

What are the common drug interactions of Zonegran and Simvastatin, by age (0-1 to 60+)? *:

0-1:

n/a

2-9:

n/a

10-19:

n/a

20-29:

n/a

30-39:

Nausea (feeling of having an urge to vomit)
Abdominal distension
Abdominal pain
Abnormal behaviour
Anticonvulsant drug level below therapeutic
Blood glucose increased
Constipation
Cough
Dementia alzheimer's type (loss of mental ability with alzheimer's symptom)
Dyspnoea (difficult or laboured respiration)

40-49:

Somnambulism (sleep walking)
Suicidal ideation
Nausea (feeling of having an urge to vomit)
Diarrhoea
Blood potassium decreased
Colon cancer
Fatigue (feeling of tiredness)
Haemorrhoids (a swollen vein or group of veins in the region of the anus)
Memory impairment
Spinal osteoarthritis (joint cartilage loss in spine)

50-59:

Diabetes mellitus (diabetes, caused by a deficiency of the pancreatic hormone insulin)
Hernia (hernia happens when part of an internal organ or tissue bulges through a weak area of muscle)
Hyperglycaemia (high blood sugar)
Neuropathy peripheral (surface nerve damage)
Suicidal ideation
Type 2 diabetes mellitus
Cholestatic liver injury (due to injury bile cannot floe from liver)
Chronic obstructive pulmonary disease (a progressive disease that makes it hard to breathe)
Dermatitis allergic (inflammation of the skin due allergic reaction)
Inguinal hernia (hernia in which a loop of intestine enters the inguinal canal; the most common type of hernia in males)

60+:

Weight decreased
Dementia (madness)
Cellulitis (infection under the skin)
Death
Decreased appetite
Dental caries
Diabetes mellitus (diabetes, caused by a deficiency of the pancreatic hormone insulin)
Diarrhoea
Dysphagia (a condition in which swallowing is difficult or painful)
Dysphonia (speech disorder attributable to a disorder of phonation)

What are the existing conditions these people have? *

Narcolepsy (brain's inability to regulate sleep-wake cycles normally): 31 people, 39.24%
Cataplexy (loss of muscle tone accompanied by full conscious awareness): 11 people, 13.92%
Seizures (abnormal excessive or synchronous neuronal activity in the brain): 8 people, 10.13%
Pain: 8 people, 10.13%
Stress And Anxiety: 7 people, 8.86%
Asthma: 7 people, 8.86%
Hyperlipidaemia (presence of excess lipids in the blood): 5 people, 6.33%
High Blood Pressure: 5 people, 6.33%
Gastroesophageal Reflux Disease (a condition in which stomach contents leak backward from the stomach into the oesophagus): 4 people, 5.06%
Depression: 4 people, 5.06%

* Approximation only. Some reports may have incomplete information.

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