Acetaminophen and codeine phosphate and Dehydration - a phase IV clinical study of FDA data

Summary:

Dehydration is reported as a side effect among people who take Acetaminophen and codeine phosphate (acetaminophen; codeine phosphate), especially for people who are female, 60+ old, have been taking the drug for 1 - 6 months also take Furosemide, and have Atrial fibrillation/flutter.

The phase IV clinical study analyzes which people have Dehydration when taking Acetaminophen and codeine phosphate. It is created by eHealthMe based on reports of 2,908 people who have side effects when taking Acetaminophen and codeine phosphate from the FDA, and is updated regularly.

What is Acetaminophen and codeine phosphate?

Acetaminophen and codeine phosphate has active ingredients of acetaminophen; codeine phosphate. It is often used in pain. eHealthMe is studying from 3,220 Acetaminophen and codeine phosphate users. Check the latest studies of Acetaminophen and codeine phosphate.

What is Dehydration?

Dehydration (dryness resulting from the removal of water) is found to be associated with 2,753 drugs and 3,350 conditions by eHealthMe. Check the latest studies of Dehydration.

eHealthMe: drug outcomes in the real world

eHealthMe runs one of the largest post-marketing drug safety studies in the world. We study millions of patients and 5,000 more each day. Our data-driven phase IV clinical trials have been referenced on 800+ peer-reviewed medical publications including The Lancet, Mayo Clinic Proceedings, and Nature. Tools to study our phase IV findings are available to the public, anonymous and free >>>.

On Aug, 30, 2026

2,908 people reported to have side effects when taking Acetaminophen and codeine phosphate.
Among them, 43 people (1.48%) have Dehydration.

Could Acetaminophen and codeine phosphate cause Dehydration?

Among these 43 people:

How long have people been on Acetaminophen and codeine phosphate when they have Dehydration? *

What is the gender of people who have Dehydration when taking Acetaminophen and codeine phosphate? *

female: 62.79 %
male: 37.21 %

What is the age of people who have Dehydration when taking Acetaminophen and codeine phosphate? *

What are other drugs people take besides Acetaminophen and codeine phosphate? *

What are other side effects people have besides Dehydration? *

Acute Kidney Failure: 11 people, 25.58%
Diarrhea: 10 people, 23.26%
Constipation: 9 people, 20.93%
Hypotension (abnormally low blood pressure): 7 people, 16.28%
Sepsis (a severe blood infection that can lead to organ failure and death): 7 people, 16.28%
Pleural Effusion (water on the lungs): 7 people, 16.28%
Malaise (a feeling of general discomfort or uneasiness): 6 people, 13.95%
Fatigue (feeling of tiredness): 6 people, 13.95%
Hyperkalemia (damage to or disease of the kidney): 5 people, 11.63%
Fever: 4 people, 9.30%

What are the existing conditions these people have? *

Type 2 Diabetes: 6 people, 13.95%
Atrial Fibrillation/flutter (atrial fibrillation and flutter are abnormal heart rhythms in which the atria, or upper chambers of the heart, are out of sync with the ventricles): 6 people, 13.95%
Joint Pain: 5 people, 11.63%
Neuralgia (pain in one or more nerves): 4 people, 9.30%
Cardiac Failure: 4 people, 9.30%
High Blood Pressure: 4 people, 9.30%
Nausea (feeling of having an urge to vomit): 4 people, 9.30%
Nausea And Vomiting: 4 people, 9.30%
Metastatic Squamous Cell Carcinoma (cancer of squamous cells spreads to other part): 4 people, 9.30%
Constipation: 3 people, 6.98%

* Approximation only. Some reports may have incomplete information.

Do you take Acetaminophen and codeine phosphate and have Dehydration?

- Check whether Dehydration is associated with a drug or a condition
- Predict drug outcomes for up to one year with AI
- Get an AI agent to monitor your drugs continuously

Related studies:

Effectiveness of, long term effects of, and alternative drugs to Acetaminophen and codeine phosphate:

Acetaminophen and codeine phosphate (3,220 reports)

Dehydration treatments and more:

Dehydration (173,274 reports)

How severe was Dehydration and when was it recovered:

Dehydration in Acetaminophen and codeine phosphate

Expand to all the drugs that have ingredients of acetaminophen; codeine phosphate:

Dehydration and drugs with ingredients of acetaminophen; codeine phosphate (948 reports)

Sub-studies by gender and age:

Female: 0-1 2-9 10-19 20-29 30-39 40-49 50-59 60+

Male: 0-1 2-9 10-19 20-29 30-39 40-49 50-59 60+

Browse all side effects of Acetaminophen and codeine phosphate:

a b c d e f g h i j k l m n o p q r s t u v w x y z

Browse all the drugs that are associated with Dehydration:

Dehydration (2,753 drugs)

Browse all the conditions that are associated with Dehydration:

Dehydration (3,350 conditions)

How the study uses the data?

The study uses data from the FDA. It is based on acetaminophen; codeine phosphate (the active ingredients of Acetaminophen and codeine phosphate) and Acetaminophen and codeine phosphate (the brand name). Other drugs that have the same active ingredients (e.g. generic drugs) are not considered. Dosage of drugs is not considered in the study.

How to use the study?

DO NOT STOP MEDICATIONS without first consulting your doctor. If there are any serious or long term adverse effects discovered in the study, discuss the study with your doctor to ensure that proper medication management will be in place if applicable.

Who is eHealthMe?

With medical big data and proven AI/ML algorithms, eHealthMe provides a platform for everyone to run phase IV clinical trials. We study millions of patients and 5,000 more each day. Results of our real-world drug study have been referenced on 800+ peer-reviewed medical publications, including The Lancet, Mayo Clinic Proceedings, and Nature. Our analysis results are available to researchers, health care professionals, patients (testimonials), and software developers (open API).

WARNING, DISCLAIMER, USE FOR PUBLICATION

WARNING: Please DO NOT STOP MEDICATIONS without first consulting a physician since doing so could be hazardous to your health.

DISCLAIMER: All material available on eHealthMe.com is for informational purposes only, and is not a substitute for medical advice, diagnosis, or treatment provided by a qualified healthcare provider. All information is observation-only. Our phase IV clinical studies alone cannot establish cause-effect relationship. Different individuals may respond to medication in different ways. Every effort has been made to ensure that all information is accurate, up-to-date, and complete, but no guarantee is made to that effect. The use of the eHealthMe site and its content is at your own risk.

If you use this eHealthMe study on publication, please acknowledge it with a citation: study title, URL, accessed date.