Acetaminophen and Bundle branch block - a phase IV clinical study of FDA data


Bundle branch block is found among people who take Acetaminophen, especially for people who are female, 60+ old, have been taking the drug for < 1 month.

The phase IV clinical study analyzes which people take Acetaminophen and have Bundle branch block. It is created by eHealthMe based on reports of 149,321 people who have side effects when taking Acetaminophen from the FDA, and is updated regularly. You can use the study as a second opinion to make health care decisions.

Phase IV trials are used to detect adverse drug outcomes and monitor drug effectiveness in the real world. With medical big data and AI algorithms, eHealthMe is running millions of phase IV trials and makes the results available to the public. Our original studies have been referenced on 600+ medical publications including The Lancet, Mayo Clinic Proceedings, and Nature.

On Sep, 06, 2023

149,321 people reported to have side effects when taking Acetaminophen.
Among them, 46 people (0.03%) have Bundle branch block.

What is Acetaminophen?

Acetaminophen has active ingredients of acetaminophen. It is often used in pain. eHealthMe is studying from 107,952 Acetaminophen users for its effectiveness, alternative drugs and more.

What is Bundle branch block?

Bundle branch block (disruption in the normal flow of electrical pulses that drive the heart beat) is found to be associated with 891 drugs and 372 conditions by eHealthMe.

Number of Acetaminophen and Bundle branch block reports submitted per year:

Could Acetaminophen cause Bundle branch block?

Time on Acetaminophen when people have Bundle branch block *:

  • < 1 month: 100 %
  • 1 - 6 months: 0.0 %
  • 6 - 12 months: 0.0 %
  • 1 - 2 years: 0.0 %
  • 2 - 5 years: 0.0 %
  • 5 - 10 years: 0.0 %
  • 10+ years: 0.0 %

Gender of people who have Bundle branch block when taking Acetaminophen *:

  • female: 56.52 %
  • male: 43.48 %

Age of people who have Bundle branch block when taking Acetaminophen *:

  • 0-1: 2.56 %
  • 2-9: 0.0 %
  • 10-19: 2.56 %
  • 20-29: 0.0 %
  • 30-39: 2.56 %
  • 40-49: 0.0 %
  • 50-59: 15.38 %
  • 60+: 69.23 %

Common drugs people take besides Acetaminophen *:

  1. Aspirin: 16 people, 34.78%
  2. Coreg: 13 people, 28.26%
  3. Folic Acid: 13 people, 28.26%
  4. Zometa: 11 people, 23.91%
  5. Ambien: 11 people, 23.91%
  6. Benadryl: 11 people, 23.91%
  7. Zoloft: 11 people, 23.91%
  8. Lisinopril: 10 people, 21.74%
  9. Acyclovir: 9 people, 19.57%
  10. Lasix: 9 people, 19.57%

Common side effects people have besides Bundle branch block *:

  1. Cardiac Failure Congestive: 19 people, 41.30%
  2. Mitral Valve Incompetence (inefficient heart valve): 16 people, 34.78%
  3. Hypotension (abnormally low blood pressure): 15 people, 32.61%
  4. Osteoarthritis (a joint disease caused by cartilage loss in a joint): 13 people, 28.26%
  5. Stress And Anxiety: 13 people, 28.26%
  6. Tricuspid Valve Incompetence (inefficient heart valve): 13 people, 28.26%
  7. Atrial Fibrillation/flutter (atrial fibrillation and flutter are abnormal heart rhythms in which the atria, or upper chambers of the heart, are out of sync with the ventricles): 12 people, 26.09%
  8. Urinary Tract Infection: 12 people, 26.09%
  9. Osteonecrosis Of Jaw (death of bone of jaw): 11 people, 23.91%
  10. Renal Cyst (kidney cyst): 11 people, 23.91%

Common conditions people have *:

  1. Stress And Anxiety: 11 people, 23.91%
  2. Dry Eyes (lack of adequate tears): 6 people, 13.04%
  3. Oral Herpes (viral infection of mouth): 6 people, 13.04%
  4. Nausea (feeling of having an urge to vomit): 6 people, 13.04%
  5. High Blood Pressure: 4 people, 8.70%
  6. Type 2 Diabetes: 3 people, 6.52%
  7. Multiple Myeloma (cancer of the plasma cells): 3 people, 6.52%
  8. Dementia Alzheimer's Type (loss of mental ability with alzheimer's symptom): 3 people, 6.52%
  9. Abdominal Discomfort: 3 people, 6.52%
  10. Chronic Lymphocytic Leukaemia (cancer in which the bone marrow makes too many lymphocytes (a type of white blood cell)): 2 people, 4.35%

* Approximation only. Some reports may have incomplete information.

Do you take Acetaminophen and have Bundle branch block?

Check whether Bundle branch block is associated with a drug or a condition

How to use the study?

You can discuss the study with your doctor, to ensure that all drug risks and benefits are fully discussed and understood.

Related studies

How severe was Bundle branch block and when was it recovered:

Expand to all the drugs that have ingredients of acetaminophen:

Alternative drugs to, pros and cons of Acetaminophen:

Common Acetaminophen side effects:

Browse all side effects of Acetaminophen:

a b c d e f g h i j k l m n o p q r s t u v w x y z

Bundle branch block treatments and more:

COVID vaccines that are related to Bundle branch block:

Common drugs associated with Bundle branch block:

All the drugs that are associated with Bundle branch block:

Common conditions associated with Bundle branch block:

All the conditions that are associated with Bundle branch block:

How the study uses the data?

The study uses data from the FDA. It is based on acetaminophen (the active ingredients of Acetaminophen) and Acetaminophen (the brand name). Other drugs that have the same active ingredients (e.g. generic drugs) are not considered. Dosage of drugs is not considered in the study.

Who is eHealthMe?

With medical big data and proven AI algorithms, eHealthMe provides a platform for everyone to run phase IV clinical trials. We study millions of patients and 5,000 more each day. Results of our real-world drug study have been referenced on 600+ medical publications, including The Lancet, Mayo Clinic Proceedings, and Nature. Our analysis results are available to researchers, health care professionals, patients (testimonials), and software developers (open API).


WARNING: Please DO NOT STOP MEDICATIONS without first consulting a physician since doing so could be hazardous to your health.

DISCLAIMER: All material available on is for informational purposes only, and is not a substitute for medical advice, diagnosis, or treatment provided by a qualified healthcare provider. All information is observation-only. Our phase IV clinical studies alone cannot establish cause-effect relationship. Different individuals may respond to medication in different ways. Every effort has been made to ensure that all information is accurate, up-to-date, and complete, but no guarantee is made to that effect. The use of the eHealthMe site and its content is at your own risk.

If you use this eHealthMe study on publication, please acknowledge it with a citation: study title, URL, accessed date.

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