Acetaminophen and Injection site warmth - a phase IV clinical study of FDA data

Summary:

Injection site warmth is reported as a side effect among people who take Acetaminophen (acetaminophen), especially for people who are female, 30-39 old, also take Diphenhydramine Hydrochloride, and have Relapsing-remitting multiple sclerosis.

The phase IV clinical study analyzes which people have Injection site warmth when taking Acetaminophen. It is created by eHealthMe based on reports of 181,086 people who have side effects when taking Acetaminophen from the FDA, and is updated regularly.

What is Acetaminophen?

Acetaminophen has active ingredients of acetaminophen. It is often used in pain. eHealthMe is studying from 183,077 Acetaminophen users. Check the latest studies of Acetaminophen.

What is Injection site warmth?

Injection site warmth is found to be associated with 524 drugs and 700 conditions by eHealthMe. Check the latest studies of Injection site warmth.

eHealthMe: drug outcomes in the real world

eHealthMe runs one of the largest post-marketing drug safety studies in the world. We study millions of patients and 5,000 more each day. Our data-driven phase IV clinical trials have been referenced on 800+ peer-reviewed medical publications including The Lancet, Mayo Clinic Proceedings, and Nature. Tools to study our phase IV findings are available to the public, anonymous and free >>>.

On Aug, 27, 2026

181,086 people reported to have side effects when taking Acetaminophen.
Among them, 65 people (0.04%) have Injection site warmth.

Could Acetaminophen cause Injection site warmth?

Among these 65 people:

What is the gender of people who have Injection site warmth when taking Acetaminophen? *

female: 87.27 %
male: 12.73 %

What is the age of people who have Injection site warmth when taking Acetaminophen? *

What are other drugs people take besides Acetaminophen? *

Diphenhydramine Hydrochloride: 19 people, 29.23%
Epinephrine: 17 people, 26.15%
Methylprednisolone: 16 people, 24.62%
Aspirin: 14 people, 21.54%
Albuterol Sulfate: 12 people, 18.46%
Humira: 10 people, 15.38%
Ibuprofen: 10 people, 15.38%
Lidocaine: 9 people, 13.85%
Benadryl: 9 people, 13.85%
Prednisone: 8 people, 12.31%

What are other side effects people have besides Injection site warmth? *

Injection Site Erythema (redness at injection site): 52 people, 80.00%
Injection Site Pain: 35 people, 53.85%
Fatigue (feeling of tiredness): 26 people, 40.00%
Pain In Extremity: 24 people, 36.92%
Dyspnea (difficult or laboured breathing): 21 people, 32.31%
Paraesthesia (sensation of tingling, tickling, prickling, pricking, or burning of a person's skin with no apparent long-term physical effect): 20 people, 30.77%
Injection Site Swelling: 18 people, 27.69%
Insomnia (sleeplessness): 17 people, 26.15%
Nasopharyngitis (inflammation of the nasopharynx): 17 people, 26.15%
Swallowing Difficulty: 17 people, 26.15%

What are the existing conditions these people have? *

Relapsing-Remitting Multiple Sclerosis (reoccurrence of an inflammatory disease in which the insulating covers of nerve cells in the brain and spinal cord are damaged): 17 people, 26.15%
Immunodeficiency Common Variable: 16 people, 24.62%
Rheumatoid Arthritis (a chronic progressive disease causing inflammation in the joints): 9 people, 13.85%
Multiple Sclerosis (a nervous system disease that affects your brain and spinal cord. it damages the myelin sheath): 5 people, 7.69%
Crohn's Disease (a condition that causes inflammation of the gastrointestinal tract): 4 people, 6.15%
Gastrointestinal Disorder (functional problems of gastrointestinal tract): 4 people, 6.15%
Primary Pulmonary Hypertension (primary high blood pressure that affects the arteries in the lungs and the right side of your heart): 3 people, 4.62%
Birth Control: 3 people, 4.62%
Depression: 2 people, 3.08%
Gastroesophageal Reflux Disease (a condition in which stomach contents leak backward from the stomach into the oesophagus): 2 people, 3.08%

* Approximation only. Some reports may have incomplete information.

Do you take Acetaminophen and have Injection site warmth?

- Check whether Injection site warmth is associated with a drug or a condition
- Predict drug outcomes for up to one year with AI
- Get an AI agent to monitor your drugs continuously

Related studies:

Effectiveness of, long term effects of, and alternative drugs to Acetaminophen:

Acetaminophen (183,077 reports)

Browse all side effects of Acetaminophen:

a b c d e f g h i j k l m n o p q r s t u v w x y z

Browse all the drugs that are associated with Injection site warmth:

Injection site warmth (524 drugs)

Browse all the conditions that are associated with Injection site warmth:

Injection site warmth (700 conditions)

How the study uses the data?

The study uses data from the FDA. It is based on acetaminophen (the active ingredients of Acetaminophen) and Acetaminophen (the brand name). Other drugs that have the same active ingredients (e.g. generic drugs) are not considered. Dosage of drugs is not considered in the study.

How to use the study?

DO NOT STOP MEDICATIONS without first consulting your doctor. If there are any serious or long term adverse effects discovered in the study, discuss the study with your doctor to ensure that proper medication management will be in place if applicable.

Who is eHealthMe?

With medical big data and proven AI/ML algorithms, eHealthMe provides a platform for everyone to run phase IV clinical trials. We study millions of patients and 5,000 more each day. Results of our real-world drug study have been referenced on 800+ peer-reviewed medical publications, including The Lancet, Mayo Clinic Proceedings, and Nature. Our analysis results are available to researchers, health care professionals, patients (testimonials), and software developers (open API).

WARNING, DISCLAIMER, USE FOR PUBLICATION

WARNING: Please DO NOT STOP MEDICATIONS without first consulting a physician since doing so could be hazardous to your health.

DISCLAIMER: All material available on eHealthMe.com is for informational purposes only, and is not a substitute for medical advice, diagnosis, or treatment provided by a qualified healthcare provider. All information is observation-only. Our phase IV clinical studies alone cannot establish cause-effect relationship. Different individuals may respond to medication in different ways. Every effort has been made to ensure that all information is accurate, up-to-date, and complete, but no guarantee is made to that effect. The use of the eHealthMe site and its content is at your own risk.

If you use this eHealthMe study on publication, please acknowledge it with a citation: study title, URL, accessed date.