Adderall and Middle insomnia - a phase IV clinical study of FDA data
Summary:
Middle insomnia is reported as a side effect among people who take Adderall (amphetamine aspartate; amphetamine sulfate; dextroamphetamine saccharate; dextroamphetamine sulfate), especially for people who are female, 30-39 old, have been taking the drug for < 1 month also take Xyrem, and have Cataplexy.
The phase IV clinical study analyzes which people have Middle insomnia when taking Adderall. It is created by eHealthMe based on reports of 50,493 people who have side effects when taking Adderall from the FDA, and is updated regularly.
What is Adderall?
Adderall has active ingredients of amphetamine aspartate; amphetamine sulfate; dextroamphetamine saccharate; dextroamphetamine sulfate. It is often used in attention deficit hyperactivity disorder. eHealthMe is studying from 64,216 Adderall users. Check the latest studies of Adderall.
What is Middle insomnia?
Middle insomnia (difficulty returning to sleep after awakening either in the middle of the night) is found to be associated with 1,048 drugs and 961 conditions by eHealthMe. Check the latest studies of Middle insomnia.
On Feb, 03, 2026
50,493 people reported to have side effects when taking Adderall.
Among them, 151 people (0.3%) have Middle insomnia.
Among these 151 people:
How long have people been on Adderall when they have Middle insomnia? *
What is the gender of people who have Middle insomnia when taking Adderall? *
What is the age of people who have Middle insomnia when taking Adderall? *
What are other drugs people take besides Adderall? *
What are other side effects people have besides Middle insomnia? *
What are the existing conditions these people have? *
* Approximation only. Some reports may have incomplete information.
Do you take Adderall and have Middle insomnia?
- Check whether Middle insomnia is associated with a drug or a condition
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Related studies:
Effectiveness of, long term effects of, and alternative drugs to Adderall:
- Adderall (64,216 reports)
Middle insomnia treatments and more:
- Middle insomnia (21,949 reports)
How severe was Middle insomnia and when was it recovered:
Expand to all the drugs that have ingredients of amphetamine aspartate; amphetamine sulfate; dextroamphetamine saccharate; dextroamphetamine sulfate:
Sub-studies by gender and age:
Female: 0-1 2-9 10-19 20-29 30-39 40-49 50-59 60+
Male: 0-1 2-9 10-19 20-29 30-39 40-49 50-59 60+
Common Adderall side effects:
- Adderall side effect: Headache (pain in head) (3,469 reports)
- Adderall side effect: Depression (3,247 reports)
- Adderall side effect: Insomnia (sleeplessness) (2,125 reports)
- Adderall side effect: Fall (1,694 reports)
- Adderall side effect: Memory loss (1,621 reports)
- Adderall side effect: Malaise (a feeling of general discomfort or uneasiness) (1,546 reports)
- Adderall side effect: Suicidal ideation (1,459 reports)
- Adderall side effect: Muscle spasms (muscle contraction) (1,134 reports)
- Adderall side effect: Tremor (trembling or shaking movements in one or more parts of your body) (1,122 reports)
- Adderall side effect: Disturbance in attention (1,114 reports)
- Adderall side effect: Migraine (headache) (1,110 reports)
- Adderall side effect: Pre-existing condition improved (1,056 reports)
- Adderall side effect: Sleep apnea syndrome (1,048 reports)
- Adderall side effect: Condition (970 reports)
- Adderall side effect: Pain in extremity (951 reports)
- Adderall side effect: Appetite - decreased (decreased appetite occurs when you have a reduced desire to eat) (937 reports)
- Adderall side effect: Therapeutic response unexpected (907 reports)
- Adderall side effect: Abdominal pain upper (877 reports)
- Adderall side effect: Paraesthesia (sensation of tingling, tickling, prickling, pricking, or burning of a person's skin with no apparent long-term physical effect) (876 reports)
- Adderall side effect: Nasopharyngitis (inflammation of the nasopharynx) (855 reports)
- Adderall side effect: Hypoaesthesia (reduced sense of touch or sensation) (854 reports)
- Adderall side effect: Abdominal discomfort (772 reports)
- Adderall side effect: Cough (768 reports)
- Adderall side effect: Gait disturbance (765 reports)
- Adderall side effect: Confusional state (738 reports)
- Adderall side effect: Surgery (737 reports)
- Adderall side effect: Hair loss (680 reports)
- Adderall side effect: Loss of consciousness (666 reports)
- Adderall side effect: Mood swings (an extreme or rapid change in mood) (664 reports)
- Adderall side effect: Aggression (637 reports)
- Adderall side effect: Hypersensitivity (628 reports)
- Adderall side effect: Vision blurred (610 reports)
- Adderall side effect: Dry mouth (566 reports)
- Adderall side effect: Dehydration (dryness resulting from the removal of water) (548 reports)
- Adderall side effect: Drug hypersensitivity (531 reports)
- Adderall side effect: Anger (524 reports)
- Adderall side effect: Emotional distress (521 reports)
- Adderall side effect: Multiple sclerosis relapse (reoccurrence of a nervous system disease that affects your brain and spinal cord. it damages the myelin sheath) (510 reports)
- Adderall side effect: Asthma (496 reports)
- Adderall side effect: Peripheral swelling (487 reports)
- Adderall side effect: Crying (484 reports)
- Adderall side effect: Road traffic accident (483 reports)
- Adderall side effect: Bronchitis (inflammation of the mucous membrane in the bronchial tubes) (480 reports)
- Adderall side effect: Hallucinations (sensations that appear real but are created by your mind) (479 reports)
- Adderall side effect: Visual impairment (465 reports)
- Adderall side effect: Injury (464 reports)
- Adderall side effect: Hospitalisation (457 reports)
- Adderall side effect: Injection site pain (455 reports)
- Adderall side effect: Prescribed overdose (432 reports)
- Adderall side effect: Drug withdrawal syndrome (interfere with normal social, occupational, or other functioning. are not due to another medical condition, drug use, or discontinuation) (427 reports)
- Adderall side effect: Drug dependence (424 reports)
- Adderall side effect: Drug effect decreased (418 reports)
- Adderall side effect: Depressed mood (414 reports)
- Adderall side effect: Neuropathy peripheral (surface nerve damage) (398 reports)
- Adderall side effect: Abdominal distension (393 reports)
- Adderall side effect: Feeling hot (384 reports)
- Adderall side effect: Nervousness (371 reports)
- Adderall side effect: Withdrawal syndrome (a discontinuation syndrome is a set of symptoms occurred due to discontinuation of substance) (370 reports)
- Adderall side effect: Mental disorder (a psychological term for a mental or behavioural pattern or anomaly that causes distress or disability) (364 reports)
- Adderall side effect: Emotional disorder (359 reports)
- Adderall side effect: Sleep walking (walking during sleep) (353 reports)
- Adderall side effect: Cognitive disorder (mental health disorders affects learning, memory, perception, and problem solving) (352 reports)
- Adderall side effect: Gastrointestinal disorder (functional problems of gastrointestinal tract) (349 reports)
- Adderall side effect: Swelling (348 reports)
- Adderall side effect: Chills (felling of cold) (346 reports)
- Adderall side effect: Influenza like illness (345 reports)
- Adderall side effect: Swallowing difficulty (329 reports)
- Adderall side effect: Oropharyngeal pain (322 reports)
- Adderall side effect: Oedema peripheral (superficial swelling) (316 reports)
- Adderall side effect: Anaemia (lack of blood) (308 reports)
- Adderall side effect: Nightmares (unpleasant dreams) (305 reports)
- Adderall side effect: Intervertebral disc protrusion (spinal disc protrusion) (303 reports)
- Adderall side effect: Diabetes (296 reports)
- Adderall side effect: Disability (290 reports)
- Adderall side effect: Speech disorder (287 reports)
- Adderall side effect: Convulsion (muscles contract and relax rapidly and repeatedly, resulting in an uncontrolled shaking of the body) (285 reports)
- Adderall side effect: Dry skin (277 reports)
- Adderall side effect: Confusion (269 reports)
- Adderall side effect: Therapeutic response decreased (less preventive response) (267 reports)
- Adderall side effect: Rheumatoid arthritis (a chronic progressive disease causing inflammation in the joints) (262 reports)
- Adderall side effect: Musculoskeletal stiffness (stiffness of the body's muscles, joints, tendons, ligaments and nerves) (256 reports)
- Adderall side effect: Muscle twitching (254 reports)
- Adderall side effect: Upper respiratory tract infection (253 reports)
- Adderall side effect: Cataplexy (loss of muscle tone accompanied by full conscious awareness) (251 reports)
- Adderall side effect: Psoriasis (immune-mediated disease that affects the skin) (245 reports)
- Adderall side effect: Gynecomastia (enlargement of the gland tissue of the male breast) (238 reports)
- Adderall side effect: Acute kidney failure (232 reports)
- Adderall side effect: Arthropathy (230 reports)
- Adderall side effect: Anhedonia (inability to experience pleasure from activities usually found enjoyable) (225 reports)
- Adderall side effect: Mania (a state of abnormally elevated or irritable mood) (224 reports)
- Adderall side effect: Feeling drunk (219 reports)
- Adderall side effect: Hepatic enzyme increased (208 reports)
- Adderall side effect: Night sweats (sweating in night) (204 reports)
- Adderall side effect: Burning sensation (202 reports)
- Adderall side effect: Limb injury (200 reports)
- Adderall side effect: Adverse event (198 reports)
- Adderall side effect: Impaired work ability (194 reports)
- Adderall side effect: Musculoskeletal pain (pain affects the bones, muscles, ligaments, tendons, and nerves) (192 reports)
- Adderall side effect: Thrombosis (formation of a blood clot inside a blood vessel) (190 reports)
- Adderall side effect: Erection problems (188 reports)
- Adderall side effect: Staphylococcal infection (an infection with staphylococcus bacteria) (187 reports)
- Adderall side effect: Limb discomfort (discomfort in leg) (185 reports)
- Adderall side effect: Initial insomnia (feeling of inadequate or poor-quality sleep) (184 reports)
- Adderall side effect: Blood potassium decreased (178 reports)
- Adderall side effect: Fear (177 reports)
- Adderall side effect: Activities of daily living impaired (176 reports)
- Adderall side effect: Cardiac disorder (172 reports)
- Adderall side effect: Osteoporosis (bones weak and more likely to break) (171 reports)
- Adderall side effect: Hallucination, auditory (perceiving sounds without auditory stimulus) (169 reports)
- Adderall side effect: Foot fracture (168 reports)
- Adderall side effect: Joint injury (167 reports)
- Adderall side effect: Ankle fracture (166 reports)
- Adderall side effect: Osteopenia (a condition where bone mineral density is lower than normal) (165 reports)
- Adderall side effect: Maternal exposure during pregnancy (use of substance during pregnancy) (164 reports)
- Adderall side effect: Bone pain (162 reports)
- Adderall side effect: Skin discoloration (159 reports)
- Adderall side effect: Device dislocation (152 reports)
- Adderall side effect: Middle insomnia (difficulty returning to sleep after awakening either in the middle of the night) (151 reports)
- Adderall side effect: Menstruation irregular (150 reports)
- Adderall side effect: Mental impairment (a condition affecting the body, perhaps through sight or hearing loss, a mobility difficulty or a health condition) (149 reports)
- Adderall side effect: Fungal infection (148 reports)
- Adderall side effect: Hangover (146 reports)
- Adderall side effect: Movement disorder (neurological syndromes where they may be excess of movement or a paucity of movement that is not connected to weakness) (145 reports)
- Adderall side effect: Gallbladder disorder (144 reports)
- Adderall side effect: Blister (small pocket of fluid within the upper layers of the skin caused by forceful rubbing (friction), burning, freezing, chemical exposure) (142 reports)
- Adderall side effect: Gastric disorder (disease of stomach) (139 reports)
- Adderall side effect: Disease recurrence (138 reports)
- Adderall side effect: Cataract (clouding of the lens inside the eye) (137 reports)
- Adderall side effect: Sepsis (a severe blood infection that can lead to organ failure and death) (135 reports)
- Adderall side effect: Viral infection (134 reports)
- Adderall side effect: Vaginal bleeding (132 reports)
- Adderall side effect: Pancreatitis (inflammation of pancreas) (128 reports)
- Adderall side effect: Scar (123 reports)
- Adderall side effect: Stomatitis (inflammation of mucous membrane of mouth) (121 reports)
- Adderall side effect: Ear pain (120 reports)
- Adderall side effect: Dental caries (119 reports)
- Adderall side effect: Gastritis (inflammation of stomach) (115 reports)
- Adderall side effect: Urinary retention (the inability to completely or partially empty the bladder) (114 reports)
- Adderall side effect: Movement - uncontrolled or slow (111 reports)
- Adderall side effect: Peripheral coldness (110 reports)
- Adderall side effect: Mental status changes (general changes in brain function, such as confusion, amnesia (memory loss), loss of alertness, loss of orientation) (109 reports)
- Adderall side effect: Alanine aminotransferase increased (106 reports)
- Adderall side effect: Inflammation (105 reports)
- Adderall side effect: Diverticulitis (digestive disease which involves the formation of pouches (diverticula) within the bowel wall) (104 reports)
- Adderall side effect: Micturition urgency (urgency to pass the urine) (102 reports)
Browse all side effects of Adderall:
a b c d e f g h i j k l m n o p q r s t u v w x y zCommon drugs associated with Middle insomnia:
- Xolair (2,139 reports)
- Prednisone (1,661 reports)
- Singulair (1,579 reports)
- Lunesta (1,286 reports)
- Symbicort (1,260 reports)
- Spiriva (1,219 reports)
- Aspirin (1,050 reports)
- Advair hfa (903 reports)
- Pantoprazole (851 reports)
- Ventolin (715 reports)
- Lyrica (657 reports)
- Metformin (655 reports)
- Vitamin d (648 reports)
- Synthroid (630 reports)
- Hetlioz (610 reports)
- Tylenol (571 reports)
- Alvesco (561 reports)
- Methotrexate (554 reports)
- Lisinopril (549 reports)
- Dupixent (530 reports)
- Omeprazole (528 reports)
- Gabapentin (519 reports)
- Amlodipine (508 reports)
- Lipitor (445 reports)
- Cymbalta (433 reports)
- Chantix (427 reports)
- Albuterol (420 reports)
- Rozerem (412 reports)
- Lorazepam (410 reports)
- Ambien (407 reports)
- Forteo (397 reports)
- Calcium (389 reports)
- Xyrem (385 reports)
- Pulmicort (376 reports)
- Simvastatin (373 reports)
- Atrovent (371 reports)
- Wellbutrin (361 reports)
- Zopiclone (359 reports)
- Benadryl (350 reports)
- Xanax (346 reports)
- Breo ellipta (343 reports)
- Niaspan (341 reports)
- Sertraline (337 reports)
- Hydrochlorothiazide (336 reports)
- Pregabalin (335 reports)
- Ibuprofen (332 reports)
- Nexium (319 reports)
- Seroquel (311 reports)
- Magnesium (309 reports)
- Cetirizine hydrochloride (305 reports)
- Atenolol (299 reports)
- Zoloft (293 reports)
- Zide (292 reports)
- Allopurinol (290 reports)
- Fish oil (283 reports)
- Furosemide (281 reports)
- Crestor (276 reports)
- Vitamin d3 (272 reports)
- Vitamin c (270 reports)
- Vitamins (269 reports)
- Morphine (267 reports)
- Vitamin b12 (257 reports)
- Zejula (256 reports)
- Zyrtec (255 reports)
- Effexor (250 reports)
- Nasonex (249 reports)
- Budesonide (237 reports)
- Flovent (236 reports)
- Fluoxetine (232 reports)
- Spironolactone (229 reports)
- Albuterol sulfate (228 reports)
- Enbrel (224 reports)
- Ativan (223 reports)
- Montelukast sodium (222 reports)
- Lamotrigine (221 reports)
- Acetaminophen (218 reports)
- Losartan (214 reports)
- Lexapro (213 reports)
- Prilosec (209 reports)
- Nitroglycerin (208 reports)
- Celebrex (205 reports)
- Levothyroxine sodium (204 reports)
- Plavix (203 reports)
- Klonopin (197 reports)
- Lasix (196 reports)
- Paroxetine (195 reports)
- Atorvastatin calcium (190 reports)
- Temazepam (188 reports)
- Abilify (187 reports)
- Belsomra (182 reports)
- Valtrex (177 reports)
- Plaquenil (176 reports)
- Rosuvastatin calcium (175 reports)
- Naproxen (174 reports)
- Acetylsalicylic acid (170 reports)
- Ampyra (165 reports)
- Cosentyx (164 reports)
- Claritin (163 reports)
- Paxil (162 reports)
- Strattera (158 reports)
- Topamax (156 reports)
- Escitalopram (155 reports)
- Norvasc (154 reports)
- Fosamax (153 reports)
- Adderall (151 reports)
- Hydroxyzine (150 reports)
- Elavil (149 reports)
- Flomax (146 reports)
- Clozapine (144 reports)
- Venlafaxine hydrochloride (143 reports)
- Advil (138 reports)
- Premarin (137 reports)
- Amlodipine besylate (136 reports)
- Qvar (134 reports)
- Citalopram hydrobromide (130 reports)
- Ranitidine (129 reports)
- Diclofenac (128 reports)
- Prozac (126 reports)
- Miralax (125 reports)
- Celexa (124 reports)
- Letairis (123 reports)
- Combivent (119 reports)
- Tysabri (117 reports)
- Lamictal (116 reports)
- Sertraline hydrochloride (115 reports)
- Clonidine (114 reports)
- Zyloprim (113 reports)
- Prevacid (112 reports)
- Mirtazapine (110 reports)
- Actemra (109 reports)
- Eliquis (108 reports)
- Advair diskus 100/50 (107 reports)
- Amoxicillin (106 reports)
- Uniphyl (105 reports)
- Biotin (103 reports)
- Proair hfa (102 reports)
- Pristiq (101 reports)
Browse all the drugs that are associated with Middle insomnia:
- Middle insomnia (1,048 drugs)
Common conditions associated with Middle insomnia:
- Asthma: 3,125 reports
- Chronic asthma: 3,119 reports
- Cannot sleep: 1,669 reports
- Parkinson's disease: 903 reports
- Depression: 818 reports
- Antidepressant therapy: 817 reports
- Hypertension: 722 reports
- Hbp: 720 reports
- Ldl/hdl ratio increased: 669 reports
- Rheumatoid arthritis: 595 reports
- Multiple sclerosis aggravated: 579 reports
- Ra: 568 reports
- Htn: 540 reports
- Heartburn: 490 reports
- Anxiety: 485 reports
- Osteoporosis: 478 reports
- Pain: 466 reports
- Pain relief: 463 reports
- Sleep disorder: 417 reports
- Sleep disorder due to general medical condition, insomnia type: 416 reports
- Tobacco user: 381 reports
- Cancer - ovaries: 316 reports
- Migraines: 254 reports
- Diabetes mellitus: 234 reports
- Chest pain: 232 reports
- Diabetes: 230 reports
- Regional enteritis: 222 reports
- Low thyroid: 219 reports
- Dm: 218 reports
- Hypersensitivity: 217 reports
- Difficulty in breathing: 209 reports
- Epilepsy: 207 reports
- Wheezing: 203 reports
- Add: 192 reports
- Attention deficit disorder with hyperactivity (addh): 189 reports
- Hypothyroidism: 183 reports
- Ulcerative colitis: 178 reports
- Circadian rhythm sleep disorder: 172 reports
- Fibromyalgia syndrome: 163 reports
- Psoriasis: 160 reports
- Copd: 154 reports
- Hallucinations: 150 reports
- Bipolar disorder: 148 reports
- Diabetes mellitus non-insulin-dependent: 145 reports
- Attention deficit/hyperactivity disorder: 144 reports
- Constipation: 142 reports
- Restless leg syndrome: 128 reports
- Relapsing-remitting multiple sclerosis: 124 reports
- Drowsiness, hypersomnia, sleepiness - during the day, somnolence: 117 reports
- Sinusitis: 115 reports
- Prostate cancer: 112 reports
- Arthritis: 108 reports
- Neuropathy peripheral: 106 reports
- Delusion: 105 reports
- Ankylosing spondylitis: 103 reports
- Thyroid diseases: 102 reports
Browse all the conditions that are associated with Middle insomnia:
- Middle insomnia (961 conditions)
Drugs similar to Adderall and Middle insomnia :
- Atomoxetine and Middle insomnia
- Clonidine and Middle insomnia
- Concerta and Middle insomnia
- Daytrana and Middle insomnia
- Dexedrine and Middle insomnia
- Dextroamphetamine sulfate and Middle insomnia
- Focalin and Middle insomnia
- Focalin xr and Middle insomnia
- Guanfacine hydrochloride and Middle insomnia
- Intuniv and Middle insomnia
- Methylphenidate hydrochloride and Middle insomnia
- Ritalin and Middle insomnia
- Ritalin la and Middle insomnia
- Strattera and Middle insomnia
- Vyvanse and Middle insomnia
- Wellbutrin and Middle insomnia
How the study uses the data?
The study uses data from the FDA. It is based on amphetamine aspartate; amphetamine sulfate; dextroamphetamine saccharate; dextroamphetamine sulfate (the active ingredients of Adderall) and Adderall (the brand name). Other drugs that have the same active ingredients (e.g. generic drugs) are not considered. Dosage of drugs is not considered in the study.
How to use the study?
DO NOT STOP MEDICATIONS without first consulting your doctor. If there are any serious or long term adverse effects discovered in the study, discuss the study with your doctor to ensure that proper medication management will be in place if applicable.
Who is eHealthMe?
With medical big data and proven AI/ML algorithms, eHealthMe provides a platform for everyone to run phase IV clinical trials. We study millions of patients and 5,000 more each day. Results of our real-world drug study have been referenced on 800+ peer-reviewed medical publications, including The Lancet, Mayo Clinic Proceedings, and Nature. Our analysis results are available to researchers, health care professionals, patients (testimonials), and software developers (open API).
WARNING, DISCLAIMER, USE FOR PUBLICATION
WARNING: Please DO NOT STOP MEDICATIONS without first consulting a physician since doing so could be hazardous to your health.
DISCLAIMER: All material available on eHealthMe.com is for informational purposes only, and is not a substitute for medical advice, diagnosis, or treatment provided by a qualified healthcare provider. All information is observation-only. Our phase IV clinical studies alone cannot establish cause-effect relationship. Different individuals may respond to medication in different ways. Every effort has been made to ensure that all information is accurate, up-to-date, and complete, but no guarantee is made to that effect. The use of the eHealthMe site and its content is at your own risk.
If you use this eHealthMe study on publication, please acknowledge it with a citation: study title, URL, accessed date.
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