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Azelaic acid and Application site pain - a phase IV clinical study of FDA data

Summary:

Application site pain is reported as a side effect among people who take Azelaic acid (azelaic acid), especially for people who are female, 60+ old, have been taking the drug for < 1 month also take Mirvaso, and have Rosacea.

The phase IV clinical study analyzes which people have Application site pain when taking Azelaic acid. It is created by eHealthMe based on reports of 728 people who have side effects when taking Azelaic acid from the FDA, and is updated regularly.

What is Azelaic acid?

Azelaic acid has active ingredients of azelaic acid. eHealthMe is studying from 737 Azelaic acid users. Check the latest studies of Azelaic acid.

What is Application site pain?

Application site pain is found to be associated with 562 drugs and 848 conditions by eHealthMe. Check the latest studies of Application site pain.

On Jul, 17, 2026

728 people reported to have side effects when taking Azelaic acid.
Among them, 11 people (1.51%) have Application site pain.

Could Azelaic acid cause Application site pain?

Among these 11 people:

How long have people been on Azelaic acid when they have Application site pain? *

  • < 1 month: 80 %
  • 1 - 6 months: 0.0 %
  • 6 - 12 months: 20 %
  • 1 - 2 years: 0.0 %
  • 2 - 5 years: 0.0 %
  • 5 - 10 years: 0.0 %
  • 10+ years: 0.0 %

What is the gender of people who have Application site pain when taking Azelaic acid? *

  • female: 100 %
  • male: 0.0 %

What is the age of people who have Application site pain when taking Azelaic acid? *

  • 0-1: 0.0 %
  • 2-9: 0.0 %
  • 10-19: 0.0 %
  • 20-29: 0.0 %
  • 30-39: 50 %
  • 40-49: 0.0 %
  • 50-59: 0.0 %
  • 60+: 50 %

What are other drugs people take besides Azelaic acid? *

  1. Mirvaso: 1 person, 9.09%

What are other side effects people have besides Application site pain? *

  1. Application Site Erythema (redness of the skin at application site): 4 people, 36.36%
  2. Pain: 3 people, 27.27%
  3. Drug Hypersensitivity: 2 people, 18.18%
  4. Discomfort: 2 people, 18.18%
  5. Cellulitis (infection under the skin): 2 people, 18.18%
  6. Skin Exfoliation (removal of the oldest dead skin cells): 1 person, 9.09%
  7. Dry Skin: 1 person, 9.09%
  8. Drug Ineffective: 1 person, 9.09%
  9. Blister (small pocket of fluid within the upper layers of the skin caused by forceful rubbing (friction), burning, freezing, chemical exposure): 1 person, 9.09%
  10. Application Site Swelling: 1 person, 9.09%

What are the existing conditions these people have? *

  1. Rosacea (a skin condition that causes facial redness): 7 people, 63.64%
  2. Rashes (redness): 2 people, 18.18%
  3. Acne (skin problems that cause pimples): 2 people, 18.18%
  4. Itching: 1 person, 9.09%
  5. High Blood Pressure: 1 person, 9.09%
  6. Back Pain: 1 person, 9.09%

* Approximation only. Some reports may have incomplete information.

Do you take Azelaic acid and have Application site pain?

- Check whether Application site pain is associated with a drug or a condition
- Predict drug outcomes for up to one year with AI
- Get an AI agent to monitor your drugs continuously

Related studies:

Effectiveness of, long term effects of, and alternative drugs to Azelaic acid:

Application site pain treatments and more:

How severe was Application site pain and when was it recovered:

Expand to all the drugs that have ingredients of azelaic acid:

Sub-studies by gender and age:

Female: 0-1 2-9 10-19 20-29 30-39 40-49 50-59 60+

Male: 0-1 2-9 10-19 20-29 30-39 40-49 50-59 60+

Browse all side effects of Azelaic acid:

a b c d e f g h i j k l m n o p q r s t u v w x y z

Browse all the drugs that are associated with Application site pain:

Browse all the conditions that are associated with Application site pain:

How the study uses the data?

The study uses data from the FDA. It is based on azelaic acid (the active ingredients of Azelaic acid) and Azelaic acid (the brand name). Other drugs that have the same active ingredients (e.g. generic drugs) are not considered. Dosage of drugs is not considered in the study.

How to use the study?

DO NOT STOP MEDICATIONS without first consulting your doctor. If there are any serious or long term adverse effects discovered in the study, discuss the study with your doctor to ensure that proper medication management will be in place if applicable.

Who is eHealthMe?

With medical big data and proven AI/ML algorithms, eHealthMe provides a platform for everyone to run phase IV clinical trials. We study millions of patients and 5,000 more each day. Results of our real-world drug study have been referenced on 800+ peer-reviewed medical publications, including The Lancet, Mayo Clinic Proceedings, and Nature. Our analysis results are available to researchers, health care professionals, patients (testimonials), and software developers (open API).

WARNING, DISCLAIMER, USE FOR PUBLICATION

WARNING: Please DO NOT STOP MEDICATIONS without first consulting a physician since doing so could be hazardous to your health.

DISCLAIMER: All material available on eHealthMe.com is for informational purposes only, and is not a substitute for medical advice, diagnosis, or treatment provided by a qualified healthcare provider. All information is observation-only. Our phase IV clinical studies alone cannot establish cause-effect relationship. Different individuals may respond to medication in different ways. Every effort has been made to ensure that all information is accurate, up-to-date, and complete, but no guarantee is made to that effect. The use of the eHealthMe site and its content is at your own risk.

If you use this eHealthMe study on publication, please acknowledge it with a citation: study title, URL, accessed date.

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