Codeine and Coma - a phase IV clinical study of FDA data

Summary:

Coma is reported as a side effect among people who take Codeine (codeine sulfate), especially for people who are female, 60+ old, have been taking the drug for < 1 month also take Acetaminophen, and have Rheumatoid arthritis.

The phase IV clinical study analyzes which people have Coma when taking Codeine. It is created by eHealthMe based on reports of 41,713 people who have side effects when taking Codeine from the FDA, and is updated regularly.

What is Codeine?

Codeine has active ingredients of codeine sulfate. It is often used in pain. eHealthMe is studying from 42,341 Codeine users. Check the latest studies of Codeine.

What is Coma?

Coma (state of unconsciousness lasting more than six hours) is found to be associated with 2,891 drugs and 3,170 conditions by eHealthMe. Check the latest studies of Coma.

On Oct, 20, 2025

41,713 people reported to have side effects when taking Codeine.
Among them, 557 people (1.34%) have Coma.

Among these 557 people:

How long have people been on Codeine when they have Coma? *

What is the gender of people who have Coma when taking Codeine? *

female: 67.65 %
male: 32.35 %

What is the age of people who have Coma when taking Codeine? *

What are other drugs people take besides Codeine? *

What are other side effects people have besides Coma? *

Abdominal Pain: 238 people, 42.73%
Arrhythmias (irregular heartbeat): 228 people, 40.93%
Drowsiness: 214 people, 38.42%
Fall: 207 people, 37.16%
Dyspnea (difficult or laboured breathing): 206 people, 36.98%
Diarrhea: 206 people, 36.98%
Ascites (accumulation of fluid in the abdominal cavity): 205 people, 36.80%
Appetite - Decreased (decreased appetite occurs when you have a reduced desire to eat): 204 people, 36.62%
Cardio-Respiratory Arrest (sudden dysfunction of heart and lungs): 204 people, 36.62%
Headache (pain in head): 204 people, 36.62%

What are the existing conditions these people have? *

Rheumatoid Arthritis (a chronic progressive disease causing inflammation in the joints): 74 people, 13.29%
Glaucoma (increased fluid pressure in the eye with vision loss): 53 people, 9.52%
Poisoning Deliberate: 27 people, 4.85%
Epilepsy (common and diverse set of chronic neurological disorders characterized by seizures): 22 people, 3.95%
Stress And Anxiety: 15 people, 2.69%
Blood Pressure Abnormal: 15 people, 2.69%
Pneumonia: 14 people, 2.51%
Depression: 11 people, 1.97%
Headache (pain in head): 8 people, 1.44%
Insomnia (sleeplessness): 8 people, 1.44%

* Approximation only. Some reports may have incomplete information.

Do you take Codeine and have Coma?

- Check whether Coma is associated with a drug or a condition
- Predict drug outcomes for up to one year with AI
- Get an AI agent to monitor your drugs continuously

Related studies:

Effectiveness of, long term effects of, and alternative drugs to Codeine:

Codeine (42,341 reports)

Coma treatments and more:

Coma (57,420 reports)

Common Codeine side effects:

Browse all side effects of Codeine:

a b c d e f g h i j k l m n o p q r s t u v w x y z

Common drugs associated with Coma:

Browse all the drugs that are associated with Coma:

Coma (2,891 drugs)

Common conditions associated with Coma:

Pain: 2,578 reports
Pain relief: 2,471 reports
Depression aggravated: 1,998 reports
Antidepressant therapy: 1,968 reports
Hypertension: 1,963 reports
Blood pressure - high: 1,924 reports
Multiple sclerosis aggravated: 1,512 reports
Acupuncture and pain: 1,424 reports
Arthritis - rheumatoid: 1,182 reports
Diabetes mellitus: 1,167 reports

Browse all the conditions that are associated with Coma:

Coma (3,170 conditions)

Drugs similar to Codeine and Coma :

How the study uses the data?

The study uses data from the FDA. It is based on codeine sulfate (the active ingredients of Codeine) and Codeine (the brand name). Other drugs that have the same active ingredients (e.g. generic drugs) are not considered. Dosage of drugs is not considered in the study.

How to use the study?

DO NOT STOP MEDICATIONS without first consulting your doctor. If there are any serious or long term adverse effects discovered in the study, discuss the study with your doctor to ensure that proper medication management will be in place if applicable.

Who is eHealthMe?

With medical big data and proven AI/ML algorithms, eHealthMe provides a platform for everyone to run phase IV clinical trials. We study millions of patients and 5,000 more each day. Results of our real-world drug study have been referenced on 800+ peer-reviewed medical publications, including The Lancet, Mayo Clinic Proceedings, and Nature. Our analysis results are available to researchers, health care professionals, patients (testimonials), and software developers (open API).

WARNING, DISCLAIMER, USE FOR PUBLICATION

WARNING: Please DO NOT STOP MEDICATIONS without first consulting a physician since doing so could be hazardous to your health.

DISCLAIMER: All material available on eHealthMe.com is for informational purposes only, and is not a substitute for medical advice, diagnosis, or treatment provided by a qualified healthcare provider. All information is observation-only. Our phase IV clinical studies alone cannot establish cause-effect relationship. Different individuals may respond to medication in different ways. Every effort has been made to ensure that all information is accurate, up-to-date, and complete, but no guarantee is made to that effect. The use of the eHealthMe site and its content is at your own risk.

If you use this eHealthMe study on publication, please acknowledge it with a citation: study title, URL, accessed date.