Profen and Coma - a phase IV clinical study of FDA data

Summary:

Coma is reported as a side effect among people who take Profen (ibuprofen), especially for people who are female, 60+ old, have been taking the drug for < 1 month also take Paracetamol, and have Suicide attempt.

The phase IV clinical study analyzes which people have Coma when taking Profen. It is created by eHealthMe based on reports of 239,319 people who have side effects when taking Profen from the FDA, and is updated regularly.

What is Profen?

Profen has active ingredients of ibuprofen. It is often used in pain. eHealthMe is studying from 245,301 Profen users. Check the latest studies of Profen.

What is Coma?

Coma (state of unconsciousness lasting more than six hours) is found to be associated with 2,881 drugs and 3,170 conditions by eHealthMe. Check the latest studies of Coma.

On Oct, 10, 2025

239,319 people reported to have side effects when taking Profen.
Among them, 1,299 people (0.54%) have Coma.

Among these 1,299 people:

* Approximation only. Some reports may have incomplete information.

Do you take Profen and have Coma?

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Related studies:

Effectiveness of, long term effects of, and alternative drugs to Profen:

Profen (245,301 reports)

Coma treatments and more:

Coma (57,420 reports)

How severe was Coma and when was it recovered:

Coma in Profen

Expand to all the drugs that have ingredients of ibuprofen:

Coma and drugs with ingredients of ibuprofen (1,490 reports)

Sub-studies by gender and age:

Female: 0-1 2-9 10-19 20-29 30-39 40-49 50-59 60+

Male: 0-1 2-9 10-19 20-29 30-39 40-49 50-59 60+

Common Profen side effects:

Profen side effect: Drug ineffective (19,260 reports)
Profen side effect: Nausea (feeling of having an urge to vomit) (17,725 reports)

Browse all side effects of Profen:

a b c d e f g h i j k l m n o p q r s t u v w x y z

Common drugs associated with Coma:

Tramadol side effect: Coma (2,322 reports)
Alprazolam side effect: Coma (2,308 reports)
Diazepam side effect: Coma (2,182 reports)
Morphine side effect: Coma (2,005 reports)
Loraz side effect: Coma (1,922 reports)
Prednisone side effect: Coma (1,876 reports)
Acetaminophen side effect: Coma (1,813 reports)
Metformin side effect: Coma (1,803 reports)
Baclofen side effect: Coma (1,798 reports)
Aspirin side effect: Coma (1,760 reports)

Browse all the drugs that are associated with Coma:

Coma (2,881 drugs)

Common conditions associated with Coma:

Pain exacerbated: 2,578 reports
Hypnosis and pain: 2,471 reports
Depression aggravated: 1,998 reports
Antidepressant therapy: 1,968 reports
Hypertension: 1,963 reports
High blood pressure: 1,924 reports
Ms hug: 1,512 reports
Acupuncture and pain: 1,424 reports
Arthritis - rheumatoid: 1,182 reports
Diabetes mellitus aggravated: 1,167 reports

Browse all the conditions that are associated with Coma:

Coma (3,170 conditions)

Drugs similar to Profen and Coma :

Related publications that referenced our studies

Moslim MA, Sodeman TC, Nawras AT, "A Case of Suggested Ibuprofen-Induced Acute Pancreatitis", American journal of therapeutics, 2016 Nov .
Moslim MA, Sodeman TC, Nawras AT, "A Case of Suggested Ibuprofen-Induced Acute Pancreatitis", American journal of therapeutics, 2016 Nov .

How the study uses the data?

The study uses data from the FDA. It is based on ibuprofen (the active ingredients of Profen) and Profen (the brand name). Other drugs that have the same active ingredients (e.g. generic drugs) are not considered. Dosage of drugs is not considered in the study.

How to use the study?

DO NOT STOP MEDICATIONS without first consulting your doctor. If there are any serious or long term adverse effects discovered in the study, discuss the study with your doctor to ensure that proper medication management will be in place if applicable.

Who is eHealthMe?

With medical big data and proven AI/ML algorithms, eHealthMe provides a platform for everyone to run phase IV clinical trials. We study millions of patients and 5,000 more each day. Results of our real-world drug study have been referenced on 800+ peer-reviewed medical publications, including The Lancet, Mayo Clinic Proceedings, and Nature. Our analysis results are available to researchers, health care professionals, patients (testimonials), and software developers (open API).

WARNING, DISCLAIMER, USE FOR PUBLICATION

WARNING: Please DO NOT STOP MEDICATIONS without first consulting a physician since doing so could be hazardous to your health.

DISCLAIMER: All material available on eHealthMe.com is for informational purposes only, and is not a substitute for medical advice, diagnosis, or treatment provided by a qualified healthcare provider. All information is observation-only. Our phase IV clinical studies alone cannot establish cause-effect relationship. Different individuals may respond to medication in different ways. Every effort has been made to ensure that all information is accurate, up-to-date, and complete, but no guarantee is made to that effect. The use of the eHealthMe site and its content is at your own risk.

If you use this eHealthMe study on publication, please acknowledge it with a citation: study title, URL, accessed date.