Exalgo and Malaise - a phase IV clinical study of FDA data

Summary:

Malaise is reported as a side effect among people who take Exalgo (hydromorphone hydrochloride), especially for people who are female, 50-59 old, have been taking the drug for 1 - 6 months also take Ms Contin, and have Breakthrough pain.

The phase IV clinical study analyzes which people have Malaise when taking Exalgo. It is created by eHealthMe based on reports of 9,796 people who have side effects when taking Exalgo from the FDA, and is updated regularly.

What is Exalgo?

Exalgo has active ingredients of hydromorphone hydrochloride. It is often used in chronic pain. eHealthMe is studying from 9,847 Exalgo users. Check the latest studies of Exalgo.

What is Malaise?

Malaise (a feeling of general discomfort or uneasiness) is found to be associated with 3,506 drugs and 5,120 conditions by eHealthMe. Check the latest studies of Malaise.

On Jul, 20, 2026

9,796 people reported to have side effects when taking Exalgo.
Among them, 14 people (0.14%) have Malaise.

Among these 14 people:

How long have people been on Exalgo when they have Malaise? *

What is the gender of people who have Malaise when taking Exalgo? *

female: 61.54 %
male: 38.46 %

What is the age of people who have Malaise when taking Exalgo? *

What are other drugs people take besides Exalgo? *

What are other side effects people have besides Malaise? *

Hypotension (abnormally low blood pressure): 4 people, 28.57%
Nausea (feeling of having an urge to vomit): 4 people, 28.57%
Weight Decreased: 3 people, 21.43%
Drug Effect Decreased: 3 people, 21.43%
Drug Withdrawal Syndrome (interfere with normal social, occupational, or other functioning. are not due to another medical condition, drug use, or discontinuation): 3 people, 21.43%
Neoplasm Progression (growth of tumour): 2 people, 14.29%
Bile Duct Obstruction (blockage in the tubes that carry bile from the liver to the gallbladder): 2 people, 14.29%
Cholangitis (infection of the bile duct): 2 people, 14.29%
Confusional State: 2 people, 14.29%
Diarrhea: 2 people, 14.29%

What are the existing conditions these people have? *

Breakthrough Pain: 4 people, 28.57%
Depression: 2 people, 14.29%
Stress And Anxiety: 2 people, 14.29%
Rheumatoid Arthritis (a chronic progressive disease causing inflammation in the joints): 2 people, 14.29%
Cancer Pain: 2 people, 14.29%
Trigeminal Neuralgia (a painful condition of the nerve responsible for most facial sensation): 1 person, 7.14%
Fibromyalgia (a long-term condition which causes pain all over the body): 1 person, 7.14%
Essential Tremor: 1 person, 7.14%
Diabetic Neuropathy (neuropathic disorders that are associated with diabetes mellitus): 1 person, 7.14%
Diabetic Complication: 1 person, 7.14%

* Approximation only. Some reports may have incomplete information.

Do you take Exalgo and have Malaise?

- Check whether Malaise is associated with a drug or a condition
- Predict drug outcomes for up to one year with AI
- Get an AI agent to monitor your drugs continuously

Related studies:

Effectiveness of, long term effects of, and alternative drugs to Exalgo:

Exalgo (9,847 reports)

Malaise treatments and more:

Malaise (529,933 reports)

Browse all side effects of Exalgo:

a b c d e f g h i j k l m n o p q r s t u v w x y z

Browse all the drugs that are associated with Malaise:

Malaise (3,506 drugs)

Browse all the conditions that are associated with Malaise:

Malaise (5,120 conditions)

How the study uses the data?

The study uses data from the FDA. It is based on hydromorphone hydrochloride (the active ingredients of Exalgo) and Exalgo (the brand name). Other drugs that have the same active ingredients (e.g. generic drugs) are not considered. Dosage of drugs is not considered in the study.

How to use the study?

DO NOT STOP MEDICATIONS without first consulting your doctor. If there are any serious or long term adverse effects discovered in the study, discuss the study with your doctor to ensure that proper medication management will be in place if applicable.

Who is eHealthMe?

With medical big data and proven AI/ML algorithms, eHealthMe provides a platform for everyone to run phase IV clinical trials. We study millions of patients and 5,000 more each day. Results of our real-world drug study have been referenced on 800+ peer-reviewed medical publications, including The Lancet, Mayo Clinic Proceedings, and Nature. Our analysis results are available to researchers, health care professionals, patients (testimonials), and software developers (open API).

WARNING, DISCLAIMER, USE FOR PUBLICATION

WARNING: Please DO NOT STOP MEDICATIONS without first consulting a physician since doing so could be hazardous to your health.

DISCLAIMER: All material available on eHealthMe.com is for informational purposes only, and is not a substitute for medical advice, diagnosis, or treatment provided by a qualified healthcare provider. All information is observation-only. Our phase IV clinical studies alone cannot establish cause-effect relationship. Different individuals may respond to medication in different ways. Every effort has been made to ensure that all information is accurate, up-to-date, and complete, but no guarantee is made to that effect. The use of the eHealthMe site and its content is at your own risk.

If you use this eHealthMe study on publication, please acknowledge it with a citation: study title, URL, accessed date.