Fentanyl and Reflux - a phase IV clinical study of FDA data

Summary:

Reflux is reported as a side effect among people who take Fentanyl (fentanyl citrate), especially for people who are female, 50-59 old, have been taking the drug for < 1 month also take Zometa, and have Multiple myeloma.

The phase IV clinical study analyzes which people have Reflux when taking Fentanyl. It is created by eHealthMe based on reports of 72,646 people who have side effects when taking Fentanyl from the FDA, and is updated regularly.

What is Fentanyl?

Fentanyl has active ingredients of fentanyl citrate. It is often used in pain. eHealthMe is studying from 73,301 Fentanyl users. Check the latest studies of Fentanyl.

What is Reflux?

Reflux (stomach contents come back up into the food pipe (gullet or oesophagus) or even into the mouth) is found to be associated with 2,586 drugs and 3,446 conditions by eHealthMe. Check the latest studies of Reflux.

On Aug, 25, 2025

72,646 people reported to have side effects when taking Fentanyl.
Among them, 711 people (0.98%) have Reflux.

Among these 711 people:

How long have people been on Fentanyl when they have Reflux? *

What is the gender of people who have Reflux when taking Fentanyl? *

female: 61.68 %
male: 38.32 %

What is the age of people who have Reflux when taking Fentanyl? *

What are other drugs people take besides Fentanyl? *

What are other side effects people have besides Reflux? *

Stress And Anxiety: 312 people, 43.88%
Osteonecrosis Of Jaw (death of bone of jaw): 251 people, 35.30%
Depression: 246 people, 34.60%
Nausea (feeling of having an urge to vomit): 238 people, 33.47%
Swallowing Difficulty: 217 people, 30.52%
Joint Pain: 211 people, 29.68%
Diarrhea: 199 people, 27.99%
Dyspnea (difficult or laboured breathing): 195 people, 27.43%
Fatigue (feeling of tiredness): 192 people, 27.00%
Osteoarthritis (a joint disease caused by cartilage loss in a joint): 192 people, 27.00%

What are the existing conditions these people have? *

Multiple Myeloma (cancer of the plasma cells): 76 people, 10.69%
Metastases To Bone (cancer spreads to bone): 56 people, 7.88%
High Blood Pressure: 43 people, 6.05%
Stress And Anxiety: 42 people, 5.91%
Depression: 41 people, 5.77%
Breast Cancer: 35 people, 4.92%
Neoplasm Malignant (cancer tumour): 28 people, 3.94%
Osteoporosis (bones weak and more likely to break): 28 people, 3.94%
Rheumatoid Arthritis (a chronic progressive disease causing inflammation in the joints): 28 people, 3.94%
Breast Cancer Metastatic: 27 people, 3.80%

* Approximation only. Some reports may have incomplete information.

Do you take Fentanyl and have Reflux?

- Check whether Reflux is associated with a drug or a condition
- Predict drug outcomes for up to one year with AI
- Get an AI agent to monitor your drugs continuously

Related studies:

Effectiveness of, long term effects of, and alternative drugs to Fentanyl:

Fentanyl (73,301 reports)

Reflux treatments and more:

Reflux (445,728 reports)

Common Fentanyl side effects:

Browse all side effects of Fentanyl:

a b c d e f g h i j k l m n o p q r s t u v w x y z

Common drugs associated with Reflux:

Browse all the drugs that are associated with Reflux:

Reflux (2,586 drugs)

Common conditions associated with Reflux:

Hypertension aggravated: 8,809 reports
Blood pressure - high: 8,796 reports
Gastroesophageal reflux disease: 8,087 reports
Heartburn: 7,618 reports
Osteoporosis: 6,424 reports
Thin bones: 6,141 reports
Reflux esophagitis: 5,786 reports
Pain exacerbated: 5,547 reports
Alternative medicine - pain relief: 5,525 reports
Non-cardiac chest pain: 5,263 reports

Browse all the conditions that are associated with Reflux:

Reflux (3,446 conditions)

Drugs similar to Fentanyl and Reflux :

How the study uses the data?

The study uses data from the FDA. It is based on fentanyl citrate (the active ingredients of Fentanyl) and Fentanyl (the brand name). Other drugs that have the same active ingredients (e.g. generic drugs) are not considered. Dosage of drugs is not considered in the study.

How to use the study?

DO NOT STOP MEDICATIONS without first consulting your doctor. If there are any serious or long term adverse effects discovered in the study, discuss the study with your doctor to ensure that proper medication management will be in place if applicable.

Who is eHealthMe?

With medical big data and proven AI/ML algorithms, eHealthMe provides a platform for everyone to run phase IV clinical trials. We study millions of patients and 5,000 more each day. Results of our real-world drug study have been referenced on 800+ peer-reviewed medical publications, including The Lancet, Mayo Clinic Proceedings, and Nature. Our analysis results are available to researchers, health care professionals, patients (testimonials), and software developers (open API).

WARNING, DISCLAIMER, USE FOR PUBLICATION

WARNING: Please DO NOT STOP MEDICATIONS without first consulting a physician since doing so could be hazardous to your health.

DISCLAIMER: All material available on eHealthMe.com is for informational purposes only, and is not a substitute for medical advice, diagnosis, or treatment provided by a qualified healthcare provider. All information is observation-only. Our phase IV clinical studies alone cannot establish cause-effect relationship. Different individuals may respond to medication in different ways. Every effort has been made to ensure that all information is accurate, up-to-date, and complete, but no guarantee is made to that effect. The use of the eHealthMe site and its content is at your own risk.

If you use this eHealthMe study on publication, please acknowledge it with a citation: study title, URL, accessed date.