Flexeril and Otitis - a phase IV clinical study of FDA data
Summary:
Otitis is found among people who take Flexeril, especially for people who are female, 40-49 old, have been taking the drug for 6 - 12 months.
The phase IV clinical study analyzes which people take Flexeril and have Otitis. It is created by eHealthMe based on reports of 32,489 people who have side effects when taking Flexeril from the FDA, and is updated regularly. You can use the study as a second opinion to make health care decisions.
Phase IV trials are used to detect adverse drug outcomes and monitor drug effectiveness in the real world. With medical big data and AI algorithms, eHealthMe is running millions of phase IV trials and makes the results available to the public. Our original studies have been referenced on 600+ medical publications including The Lancet, Mayo Clinic Proceedings, and Nature.
32,489 people reported to have side effects when taking Flexeril.
Among them, 122 people (0.38%) have Otitis.
What is Flexeril?
Flexeril has active ingredients of cyclobenzaprine hydrochloride. It is often used in muscle spasms. eHealthMe is studying from 35,864 Flexeril users for its effectiveness, alternative drugs and more.
What is Otitis?
Otitis (ear infection) is found to be associated with 2,370 drugs and 1,628 conditions by eHealthMe.
Number of Flexeril and Otitis reports submitted per year:

Time on Flexeril when people have Otitis *:
Gender of people who have Otitis when taking Flexeril*:
Age of people who have Otitis when taking Flexeril *:
Common drugs people take besides Flexeril *:
Common side effects people have besides Otitis *:
Common conditions people have *:
* Approximation only. Some reports may have incomplete information.
Do you take Flexeril and have Otitis?
Check whether Otitis is associated with a drug or a conditionHow to use the study?
You can discuss the study with your doctor, to ensure that all drug risks and benefits are fully discussed and understood.
Related studies
How severe was Otitis and when was it recovered:
Expand to all the drugs that have ingredients of cyclobenzaprine hydrochloride:
Alternative drugs to, pros and cons of Flexeril:
- Flexeril (35,864 reports)
Common Flexeril side effects:
- Abasia (inability to walk): 182 reports
- Abdominal discomfort: 528 reports
- Abdominal distension: 397 reports
- Abdominal pain: 1,129 reports
- Abdominal pain lower: 119 reports
- Abdominal pain upper: 722 reports
- Abnormal behavior: 144 reports
- Abnormal dreams: 133 reports
- Abscess (pus): 103 reports
- Acne (skin problems that cause pimples): 103 reports
- Activities of daily living impaired: 190 reports
- Acute kidney failure: 783 reports
- Acute myocardial infarction (acute heart attack): 172 reports
- Adverse drug reaction: 159 reports
- Adverse event: 175 reports
- Aggression: 165 reports
- Agitation (state of anxiety or nervous excitement): 390 reports
- Agranulocytosis (a deficiency of granulocytes in the blood, causing increased vulnerability to infection): 226 reports
- Alanine aminotransferase increased: 207 reports
- Allergic rhinitis: 119 reports
- Anaemia (lack of blood): 1,092 reports
- Anaphylaxis (serious allergic reaction that is rapid in onset and may cause death): 186 reports
- Anger: 157 reports
- Anhedonia (inability to experience pleasure from activities usually found enjoyable): 474 reports
- Ankle fracture: 143 reports
- Ankylosing spondylitis (type of arthritis affecting the spine): 105 reports
- Anorexia (eating disorder characterized by immoderate food restriction and irrational fear of gaining weight): 116 reports
- Aortic arteriosclerosis (hardening of the aortic arteries): 117 reports
- Appetite - decreased (decreased appetite occurs when you have a reduced desire to eat): 614 reports
- Appetite - increased (increased appetite is when you want to eat much more often or in larger quantities than your body requires): 114 reports
- Arrhythmias (irregular heartbeat): 522 reports
- Arthritis (form of joint disorder that involves inflammation of one or more joints): 573 reports
- Arthropathy: 381 reports
- Aseptic necrosis (the death of bone tissue due to a lack of blood supply): 289 reports
- Aspartate aminotransferase increased: 209 reports
- Asthma: 460 reports
- Atelectasis (partial or complete collapse of the lung): 309 reports
- Atherosclerosis (disorder of the arteries): 192 reports
- Atrial fibrillation/flutter (atrial fibrillation and flutter are abnormal heart rhythms in which the atria, or upper chambers of the heart, are out of sync with the ventricles): 405 reports
- Back disorder: 221 reports
- Back injury: 156 reports
- Back pain: 2,261 reports
- Balance disorder: 379 reports
- Bipolar disorder (mood disorder): 127 reports
- Blindness: 123 reports
- Blister (small pocket of fluid within the upper layers of the skin caused by forceful rubbing (friction), burning, freezing, chemical exposure): 200 reports
- Blood alkaline phosphatase increased: 121 reports
- Blood creatinine increased: 193 reports
- Blood glucose decreased: 149 reports
- Blood glucose increased: 494 reports
- Blood potassium decreased: 166 reports
- Bone density decreased: 170 reports
- Bone disorder: 477 reports
- Bone lesion (bone with abnormalities. bone lesions can result from growth formations, infections, or injuries): 185 reports
- Bone pain: 493 reports
- Bradycardia (abnormally slow heart action): 130 reports
- Breast cancer: 124 reports
- Breathing difficulty: 2,166 reports
- Broken bone: 125 reports
- Bronchitis (inflammation of the mucous membrane in the bronchial tubes): 846 reports
- Burning sensation: 357 reports
- Bursitis (inflammation of a bursa, typically one in the knee, elbow, or shoulder): 217 reports
- Cardiac arrest: 250 reports
- Cardiac disorder: 268 reports
- Cardiac failure: 112 reports
- Cardiac failure congestive: 605 reports
- Cardiac murmur (an heart sound in valve abnormality): 168 reports
- Cardiomyopathy (weakening of the heart muscle): 168 reports
- Cardio-respiratory arrest (sudden dysfunction of heart and lungs): 102 reports
- Carpal tunnel syndrome (nerve compression at wrist results numbness weakness, pain , swelling): 190 reports
- Cataract (clouding of the lens inside the eye): 332 reports
- Cellulitis (infection under the skin): 523 reports
- Chest pain: 1,803 reports
- Chills (felling of cold): 546 reports
- Cholecystitis (infection of gallbladder): 116 reports
- Cholecystitis chronic (long lasting infection of gallbladder): 140 reports
- Chronic kidney disease: 662 reports
- Chronic obstructive pulmonary disease (a progressive disease that makes it hard to breathe): 523 reports
- Cognitive disorder (mental health disorders affects learning, memory, perception, and problem solving): 218 reports
- Colitis (inflammation of colon): 141 reports
- Completed suicide (act of taking one's own life): 106 reports
- Compression fracture (fracture due to pressure caused by injury): 176 reports
- Condition: 698 reports
- Confusion: 216 reports
- Confusional state: 709 reports
- Consciousness - decreased: 202 reports
- Constipation: 1,083 reports
- Convulsion (muscles contract and relax rapidly and repeatedly, resulting in an uncontrolled shaking of the body): 381 reports
- Coronary artery occlusion (complete obstruction of blood flow in a coronary artery): 124 reports
- Coronary heart disease (narrowing or blockage of the coronary arteries): 399 reports
- Cough: 1,007 reports
- Coughing up blood: 143 reports
- Crohn's disease (condition that causes inflammation of the gastrointestinal tract): 187 reports
- Crying: 232 reports
- Cuts and puncture wounds: 180 reports
- Cyst (a closed sac): 130 reports
- Death: 488 reports
- Decreased interest: 171 reports
- Deep venous thrombosis (blood clot in a major vein that usually develops in the legs and/or pelvis): 758 reports
- Deformity (disfigurement): 239 reports
- Dehydration (dryness resulting from the removal of water): 707 reports
- Delirium (wild excitement): 103 reports
- Dental caries: 371 reports
- Depressed level of consciousness: 107 reports
- Depressed mood: 181 reports
- Depression: 2,268 reports
- Dermatitis (inflammation of the skin resulting from direct irritation by an external agent or an allergic reaction to it): 115 reports
- Diabetes: 505 reports
- Diabetes mellitus inadequate control: 120 reports
- Diabetic ketoacidosis (diabetic ketoacidosis (dka) is high concentrations of ketone bodies): 126 reports
- Diabetic neuropathy (neuropathic disorders that are associated with diabetes mellitus): 110 reports
- Diarrhea: 1,853 reports
- Diplopia (double vision): 164 reports
- Disability: 160 reports
- Discomfort: 236 reports
- Disease progression: 144 reports
- Disturbance in attention: 299 reports
- Diverticulitis (digestive disease which involves the formation of pouches (diverticula) within the bowel wall): 133 reports
- Diverticulum (out pouching of a hollow (or a fluid-filled) structure in the body): 190 reports
- Dizziness: 2,088 reports
- Drowsiness: 889 reports
- Drug abuse and dependence: 231 reports
- Drug dependence: 480 reports
- Drug effect decreased: 260 reports
- Drug hypersensitivity: 1,007 reports
- Drug ineffective: 2,258 reports
- Drug intolerance (drug sensitivity): 207 reports
- Drug withdrawal syndrome (interfere with normal social, occupational, or other functioning. are not due to another medical condition, drug use, or discontinuation): 537 reports
- Dry eyes (lack of adequate tears): 203 reports
- Dry mouth: 511 reports
- Dry skin: 225 reports
- Dyskinesia (abnormality or impairment of voluntary movement): 176 reports
- Dyspnea exertional: 257 reports
- Dysstasia (difficulty in standing): 134 reports
- Ear pain: 271 reports
- Eating disorder: 123 reports
- Emotional disorder: 127 reports
- Emotional distress: 841 reports
- Emphysema (chronic respiratory disease - over inflation of the air sacs (alveoli) in the lungs): 132 reports
- Encephalopathy (functioning of the brain is affected by some agent or condition): 113 reports
- Enlarged heart: 215 reports
- Erection problems: 186 reports
- Exostosis (formation of new bone on the surface of a bone): 258 reports
- Eye pain: 177 reports
- Facial pain: 134 reports
- Fainting (loss of consciousness and postural tone): 557 reports
- Fall: 1,872 reports
- Fatigue (feeling of tiredness): 2,957 reports
- Fear: 175 reports
- Febrile neutropenia (fever with reduced white blood cells): 124 reports
- Feeling cold: 123 reports
- Feeling hot: 195 reports
- Feeling jittery: 118 reports
- Femur fracture: 141 reports
- Fever: 1,224 reports
- Fibromyalgia (a long-term condition which causes pain all over the body): 522 reports
- Fistula (an abnormal connection or passageway between two): 143 reports
- Flank pain (a distressing sensation experienced around the lower back and the upper abdomen): 102 reports
- Flatulence (flatus expelled through the anus): 161 reports
- Fluid retention (an abnormal accumulation of fluid in the blood): 195 reports
- Foot deformity (functional disability of foot): 102 reports
- Foot fracture: 251 reports
- Fungal infection: 129 reports
- Gait disturbance: 1,052 reports
- Gallbladder disorder: 206 reports
- Gallstones (stone formation by bile component): 418 reports
- Gastric disorder (disease of stomach): 144 reports
- Gastric ulcer (stomach ulcer): 276 reports
- Gastritis (inflammation of stomach): 274 reports
- Gastroenteritis (inflammation of stomach and intestine): 125 reports
- Gastroenteritis viral (inflammation of stomach and intestine caused by virus infection): 105 reports
- Gastroesophageal reflux disease (a condition in which stomach contents leak backward from the stomach into the oesophagus): 937 reports
- Gastrointestinal disorder (functional problems of gastrointestinal tract): 211 reports
- Gastrointestinal haemorrhage (bleeding gastrointestinal tract): 364 reports
- General physical health deterioration (weak health status): 384 reports
- Gingival bleeding (bleeding gums): 128 reports
- Gingival pain (gum pain): 101 reports
- Gingivitis (inflammation of gums): 121 reports
- Glaucoma (increased fluid pressure in the eye with vision loss): 107 reports
- Haematemesis (vomiting of blood): 146 reports
- Haematochezia (passage of stools containing blood): 260 reports
- Haematocrit decreased: 157 reports
- Haematoma (collection of blood outside the blood vessels): 129 reports
- Haematuria (presence of blood in urine): 188 reports
- Haemoglobin decreased: 363 reports
- Haemorrhage (bleeding): 247 reports
- Haemorrhoids (a swollen vein or group of veins in the region of the anus): 280 reports
- Hair loss: 681 reports
- Hallucinations (sensations that appear real but are created by your mind): 366 reports
- Headache (pain in head): 2,577 reports
- Head injury: 840 reports
- Hearing loss: 134 reports
- Heart attack: 705 reports
- Heart palpitations (feelings or sensations that your heart is pounding or racing): 566 reports
- Heart rate increased: 528 reports
- Heart rate irregular: 213 reports
- Hepatic enzyme increased: 180 reports
- Hepatic steatosis (fatty liver disease): 179 reports
- Hernia (hernia happens when part of an internal organ or tissue bulges through a weak area of muscle): 147 reports
- Herpes zoster: 229 reports
- Hiatal hernia (hernia resulting from the protrusion of part of the stomach through the diaphragm): 255 reports
- High blood cholesterol: 602 reports
- High blood pressure: 1,934 reports
- Hip fracture: 147 reports
- Hoarseness or changing voice: 273 reports
- Hospitalisation: 109 reports
- Hot flush (sudden feelings of heat): 318 reports
- Hyperglycemia (high blood sugar): 206 reports
- Hyperhidrosis (abnormally increased sweating): 699 reports
- Hyperkalemia (damage to or disease of the kidney): 150 reports
- Hyperlipidaemia (presence of excess lipids in the blood): 292 reports
- Hypersensitivity: 492 reports
- Hypoaesthesia (reduced sense of touch or sensation): 1,264 reports
- Hypoglycemia (low blood sugar): 143 reports
- Hypokalemia (low potassium): 278 reports
- Hypokinesia (decreased bodily movement): 115 reports
- Hyponatremia (abnormally low level of sodium in the blood; associated with dehydration): 170 reports
- Hypophagia (reduced food intake): 209 reports
- Hypotension (abnormally low blood pressure): 798 reports
- Hypothyroidism (abnormally low activity of the thyroid gland, resulting in retardation of growth and mental development): 243 reports
- Ill-defined disorder: 111 reports
- Impaired gastric emptying: 125 reports
- Impaired healing: 304 reports
- Impaired work ability: 133 reports
- Indigestion: 518 reports
- Infection: 448 reports
- Inflammation: 201 reports
- Influenza like illness: 343 reports
- Injection site bruising: 183 reports
- Injection site erythema (redness at injection site): 241 reports
- Injection site haemorrhage (bleeding from injection site): 153 reports
- Injection site pain: 647 reports
- Injection site pruritus (severe itching at injection site): 129 reports
- Injection site reaction: 138 reports
- Injection site swelling: 136 reports
- Injury: 1,080 reports
- Insomnia (sleeplessness): 1,649 reports
- Intentional overdose: 128 reports
- International normalised ratio increased: 135 reports
- Interstitial lung disease: 133 reports
- Intervertebral disc degeneration (spinal disc degeneration): 470 reports
- Intervertebral disc disorder (spinal disc disorder): 178 reports
- Intervertebral disc protrusion (spinal disc protrusion): 687 reports
- Intestinal obstruction: 192 reports
- Irritability: 293 reports
- Irritable bowel syndrome: 189 reports
- Itching: 800 reports
- Jaw disorder (jaw disease): 104 reports
- Joint dislocation (a joint position is changed from normal position): 113 reports
- Joint injury: 196 reports
- Joint pain: 2,108 reports
- Joint range of motion decreased (disease of joint movement): 103 reports
- Joint stiffness: 179 reports
- Joint swelling: 584 reports
- Kidney infection: 104 reports
- Kidney stones: 275 reports
- Kyphosis (a condition of over-curvature of the thoracic vertebrae (upper back)): 167 reports
- Left ventricular hypertrophy (the thickening of the myocardium (muscle) of the left ventricle of the heart): 101 reports
- Leukocytosis (increased white blood cells): 144 reports
- Limb discomfort (discomfort in leg): 146 reports
- Limb injury: 141 reports
- Localised infection (infection at the single location): 130 reports
- Local swelling (swelling at the site of some application of substance or injury): 157 reports
- Loose tooth: 155 reports
- Loss of consciousness: 628 reports
- Low tissue oxygen: 170 reports
- Lumbar spinal stenosis (a medical condition in which the spinal canal narrows and compresses the spinal cord and nerves at the level of the lumbar bone): 132 reports
- Lung disorder (lung disease): 182 reports
- Lung infiltration (a substance that normally includes fluid, inflammatory exudates or cells that fill a region of lung): 137 reports
- Lung neoplasm (tumour of lung): 147 reports
- Lymph follicular hypertrophy (an increase in the size of the lymph node follicles): 302 reports
- Malaise (a feeling of general discomfort or uneasiness): 1,341 reports
- Malignant neoplasm progression (cancer tumour came back): 120 reports
- Malnutrition (condition that results from eating a diet in which certain nutrients are lacking): 108 reports
- Mastication disorder (disease of chewing food): 102 reports
- Memory loss: 1,116 reports
- Mental disorder (a psychological term for a mental or behavioural pattern or anomaly that causes distress or disability): 267 reports
- Mental impairment (a condition affecting the body, perhaps through sight or hearing loss, a mobility difficulty or a health condition): 127 reports
- Mental status changes (general changes in brain function, such as confusion, amnesia (memory loss), loss of alertness, loss of orientation): 290 reports
- Metastases to bone (cancer spreads to bone): 226 reports
- Metastases to spine (cancer spreads to spine): 102 reports
- Migraine (headache): 704 reports
- Mitral valve incompetence (inefficient heart valve): 247 reports
- Mobility decreased (ability to move is reduced): 220 reports
- Mood swings (an extreme or rapid change in mood): 286 reports
- Mouth ulcers: 210 reports
- Movement disorder (neurological syndromes where they may be excess of movement or a paucity of movement that is not connected to weakness): 130 reports
- Multiple myeloma (cancer of the plasma cells): 199 reports
- Multiple sclerosis (a nervous system disease that affects your brain and spinal cord. it damages the myelin sheath): 211 reports
- Multiple sclerosis relapse (reoccurrence of a nervous system disease that affects your brain and spinal cord. it damages the myelin sheath): 237 reports
- Muscle aches (muscle pain): 905 reports
- Muscle spasms (muscle contraction): 1,350 reports
- Muscle strain (an injury to a muscle in which the muscle fibres tear): 188 reports
- Muscle tightness: 105 reports
- Muscle twitching: 138 reports
- Musculoskeletal chest pain (pain in chest muscle or nerve or bones): 189 reports
- Musculoskeletal discomfort (discomfort in the body's muscles, joints, tendons, ligaments and nerves): 143 reports
- Musculoskeletal pain (pain affects the bones, muscles, ligaments, tendons, and nerves): 596 reports
- Musculoskeletal stiffness (stiffness of the body's muscles, joints, tendons, ligaments and nerves): 487 reports
- Nasal congestion (blockage of the nasal passages usually due to membranes lining the nose becoming swollen from inflamed blood vessels): 224 reports
- Nasopharyngitis (inflammation of the nasopharynx): 501 reports
- Nausea (feeling of having an urge to vomit): 2,901 reports
- Nausea and vomiting: 1,816 reports
- Neck pain: 894 reports
- Neoplasm malignant (cancer tumour): 169 reports
- Nephrogenic anaemia (anaemia due to kidney disease): 145 reports
- Nerve compression: 116 reports
- Nervousness: 299 reports
- Nervous system disorder (a general class of medical conditions affecting the nervous system): 113 reports
- Neuralgia (pain in one or more nerves): 197 reports
- Neuropathy peripheral (surface nerve damage): 676 reports
- Nightmares (unpleasant dreams): 152 reports
- Night sweats (sweating in night): 327 reports
- Nodule (a small rock or mineral cluster): 130 reports
- Nosebleed (bleeding from nose): 274 reports
- Obsessive-compulsive disorder (an anxiety disorder characterized by intrusive thoughts that produce uneasiness, apprehension, fear, or worry;): 133 reports
- Oedema (fluid collection in tissue): 344 reports
- Oedema peripheral (superficial swelling): 1,136 reports
- Oesophagitis (inflammation of oesophagus): 111 reports
- Oral candidiasis (fungal infection of mouth): 126 reports
- Oral pain: 241 reports
- Oropharyngeal pain: 436 reports
- Osteoarthritis (a joint disease caused by cartilage loss in a joint): 921 reports
- Osteolysis (dissolution of bone): 131 reports
- Osteomyelitis (infection of bone): 504 reports
- Osteonecrosis of jaw (death of bone of jaw): 606 reports
- Osteopenia (a condition where bone mineral density is lower than normal): 417 reports
- Osteoporosis (bones weak and more likely to break): 584 reports
- Osteosclerosis (an elevation in bone density): 125 reports
- Otitis (ear infection): 122 reports
- Overdose: 425 reports
- Oxygen saturation decreased: 161 reports
- Pain: 3,981 reports
- Pain in extremity: 1,818 reports
- Pain in jaw: 498 reports
- Pancreatitis (inflammation of pancreas): 272 reports
- Pancreatitis acute (sudden inflammation of pancreas): 102 reports
- Pancytopenia (medical condition in which there is a reduction in the number of red and white blood cells, as well as platelets): 185 reports
- Panic disorder: 299 reports
- Paraesthesia (sensation of tingling, tickling, prickling, pricking, or burning of a person's skin with no apparent long-term physical effect): 954 reports
- Paranoia (psychotic disorder characterized by delusions of persecution with or without grandeur): 146 reports
- Pelvic pain: 106 reports
- Pericardial effusion (fluid around the heart): 139 reports
- Periodontal disease (disease that attacks the gum and bone and around the teeth): 129 reports
- Periodontitis (inflammation of the tissue around the teeth): 121 reports
- Peripheral swelling: 452 reports
- Pharyngitis (inflammation of the pharynx, causing a sore throat): 109 reports
- Photophobia (extreme sensitivity to light): 176 reports
- Physical disability: 115 reports
- Pleural effusion (water on the lungs): 390 reports
- Pneumonia: 1,361 reports
- Pneumonia aspiration (bronchopneumonia that develops due to the entrance of foreign materials into the bronchial tree): 121 reports
- Pollakiuria (abnormally frequent passage of relatively small quantities or urine): 219 reports
- Poor quality sleep: 110 reports
- Post-traumatic stress disorder: 103 reports
- Pre-existing condition improved: 141 reports
- Primary sequestrum (piece of dead bone that has become separated during the process of necrosis from normal/sound bone): 129 reports
- Procedural pain: 125 reports
- Productive cough: 232 reports
- Psoriasis (immune-mediated disease that affects the skin): 278 reports
- Psoriatic arthropathy (inflammation of the skin and joints with kin condition which typically causes patches (plaques) of red, scaly skin to develop): 102 reports
- Pulmonary congestion (congestion in the lungs): 101 reports
- Pulmonary embolism (blockage of the main artery of the lung): 752 reports
- Pulmonary hypertension (increase in blood pressure in the lung artery): 196 reports
- Pulmonary oedema (fluid accumulation in the lungs): 190 reports
- Rash erythematous (redness of the skin): 123 reports
- Rashes (redness): 1,549 reports
- Rash pruritic (redness with itching): 134 reports
- Rectal haemorrhage (bleeding from anus): 278 reports
- Red blood cell count decreased: 137 reports
- Renal cyst (kidney cyst): 146 reports
- Renal disorder (kidney disease): 174 reports
- Renal failure acute (rapid kidney dysfunction): 276 reports
- Renal failure chronic (long lasting kidney dysfunction): 188 reports
- Renal impairment (severely reduced kidney function): 150 reports
- Renal injury (kidney injury): 180 reports
- Respiratory acidosis (respiratory failure or ventilatory failure, causes the ph of blood and other bodily fluids to decrease): 267 reports
- Respiratory disorder (respiratory disease): 162 reports
- Respiratory tract congestion (blockage on respiratory system): 102 reports
- Restless leg syndrome (a powerful urge to move your legs): 194 reports
- Rhabdomyolysis (a condition in which damaged skeletal muscle tissue breaks down): 107 reports
- Rheumatoid arthritis (a chronic progressive disease causing inflammation in the joints): 441 reports
- Rib fracture: 272 reports
- Rickets (softening of bones): 131 reports
- Road traffic accident: 472 reports
- Rotator cuff syndrome (a spectrum of conditions affecting the rotator cuff tendons of the shoulder): 285 reports
- Scar: 207 reports
- Sciatica (a set of symptoms including pain caused by general compression or irritation of one of five spinal nerve roots of each sciatic nerve): 244 reports
- Scoliosis (a medical condition in which a person's spine is curved from side to side): 201 reports
- Sedation: 156 reports
- Seizures (abnormal excessive or synchronous neuronal activity in the brain): 170 reports
- Sepsis (a severe blood infection that can lead to organ failure and death): 413 reports
- Sinus congestion (blockage of sinus): 136 reports
- Sinus disorder (disease of sinus): 207 reports
- Sinusitis (inflammation of sinus): 839 reports
- Sinus tachycardia (a heart rhythm with elevated rate of impulses originating from the sinoatrial node): 203 reports
- Sjogren syndrome (a disease that causes dryness in the mouth and eyes): 110 reports
- Skin blushing/flushing (a sudden reddening of the face, neck): 319 reports
- Skin discoloration: 190 reports
- Skin disorder (skin disease): 133 reports
- Skin exfoliation (removal of the oldest dead skin cells): 146 reports
- Sleep apnea syndrome: 335 reports
- Sleep disorder: 346 reports
- Sneezing: 106 reports
- Speech disorder: 242 reports
- Speech impairment (adult) (inability to speak (adult)): 325 reports
- Spinal column stenosis (narrowing of spinal column): 228 reports
- Spinal compression fracture (fracture due to spinal compression on bone): 151 reports
- Spinal disorder (disease of spine a back bone): 163 reports
- Spinal fracture (fracture in one of vertebrae): 128 reports
- Spinal osteoarthritis (joint cartilage loss in spine): 440 reports
- Splenomegaly (enlargement of spleen): 105 reports
- Stable angina (a constant chest pain): 191 reports
- Staphylococcal infection (an infection with staphylococcus bacteria): 270 reports
- Stomatitis (inflammation of mucous membrane of mouth): 303 reports
- Stress and anxiety: 2,812 reports
- Stroke (sudden death of a portion of the brain cells due to a lack of oxygen): 638 reports
- Suicidal ideation: 587 reports
- Suicide attempt: 304 reports
- Surgery: 181 reports
- Swallowing difficulty: 651 reports
- Swelling: 457 reports
- Swelling face: 280 reports
- Systemic lupus erythematosus (an autoimmune disease, which means the body's immune system mistakenly, attacks healthy tissue): 132 reports
- Taste - impaired: 228 reports
- Tenderness (pain or discomfort when an affected area is touched): 213 reports
- Tendonitis (a condition that causes pain and swelling of tendons): 172 reports
- The flu (the flu is caused by an influenza virus): 348 reports
- Therapeutic response decreased (less preventive response): 178 reports
- Therapeutic response unexpected: 230 reports
- Thirst: 109 reports
- Throat irritation: 107 reports
- Thrombocytopenia (decrease of platelets in blood): 438 reports
- Thrombosis (formation of a blood clot inside a blood vessel): 352 reports
- Thyroid diseases: 101 reports
- Thyroid neoplasm (tumour of thyroid): 113 reports
- Tinnitus (a ringing in the ears): 270 reports
- Tooth abscess (pus formation in tooth): 355 reports
- Toothaches (tooth pain): 151 reports
- Tooth disorder (tooth disease): 272 reports
- Tooth extraction: 254 reports
- Tooth fracture: 218 reports
- Tooth loss: 200 reports
- Transient ischaemic attack (a transient episode of neurologic dysfunction caused by ischemia (loss of blood flow)): 255 reports
- Tremor (trembling or shaking movements in one or more parts of your body): 714 reports
- Tricuspid valve incompetence (inefficient heart valve): 247 reports
- Tumor: 153 reports
- Type 2 diabetes: 339 reports
- Ulcerative colitis (inflammatory bowel disease (ibd). it causes swelling, ulcerations, and loss of function of the large intestine): 118 reports
- Unresponsive to stimuli: 127 reports
- Upper limb fracture: 117 reports
- Upper respiratory tract infection: 407 reports
- Urinary incontinence (inability to control the flow of urine and involuntary urination): 254 reports
- Urinary retention (the inability to completely or partially empty the bladder): 229 reports
- Urinary tract infection: 1,119 reports
- Urination - painful: 294 reports
- Urticaria (rash of round, red welts on the skin that itch intensely): 342 reports
- Vaginal bleeding: 134 reports
- Ventricular extrasystoles (premature cardiac contraction): 111 reports
- Viral infection: 156 reports
- Vision blurred: 691 reports
- Visual acuity reduced (reduced clearness of vision): 145 reports
- Visual impairment: 362 reports
- Weakness: 2,149 reports
- Weight decreased: 1,388 reports
- Weight increased: 1,117 reports
- Weight loss: 211 reports
- Wheezing (a high-pitched whistling sound made while you breath): 240 reports
- White blood cell count decreased: 232 reports
- White blood cell count increased: 238 reports
- Withdrawal syndrome (a discontinuation syndrome is a set of symptoms occurred due to discontinuation of substance): 213 reports
- Wound: 145 reports
Browse all side effects of Flexeril:
a b c d e f g h i j k l m n o p q r s t u v w x y zOtitis treatments and more:
- Otitis (26,212 reports)
COVID vaccines that are related to Otitis:
- Otitis in Moderna COVID Vaccine
- Otitis in Pfizer BioNTech Covid Vaccine
- Otitis in Johnson and Johnson Covid Vaccine
Common drugs associated with Otitis:
- Accutane: 144 reports
- Acetaminophen: 384 reports
- Acetylsalicylic acid: 338 reports
- Actemra: 446 reports
- Actonel: 117 reports
- Adcirca: 216 reports
- Adderall: 147 reports
- Adempas: 107 reports
- Advair hfa: 297 reports
- Advil: 156 reports
- Afinitor: 166 reports
- Albuterol: 420 reports
- Albuterol sulfate: 127 reports
- Allegra: 185 reports
- Allopurinol: 162 reports
- Alprazolam: 175 reports
- Alvesco: 128 reports
- Ambien: 252 reports
- Amlodipine: 323 reports
- Amoxicillin: 408 reports
- Arava: 597 reports
- Asa: 118 reports
- Aspirin: 1,155 reports
- Atenolol: 205 reports
- Ativan: 207 reports
- Augmentin: 190 reports
- Avonex: 195 reports
- Azathioprine: 109 reports
- Azelastine: 117 reports
- Baclofen: 200 reports
- Bactrim: 134 reports
- Benadryl: 301 reports
- Calcium: 384 reports
- Carvedilol: 107 reports
- Celebrex: 287 reports
- Celexa: 128 reports
- Cimzia: 205 reports
- Ciprodex: 121 reports
- Claritin: 168 reports
- Clonazepam: 268 reports
- Clonidine: 137 reports
- Cosentyx: 684 reports
- Coumadin: 287 reports
- Crestor: 157 reports
- Cymbalta: 324 reports
- Depakote: 117 reports
- Diazepam: 144 reports
- Diclofenac: 308 reports
- Diclofenac potassium: 204 reports
- Diphen: 848 reports
- Diphenhydramine hydrochloride: 101 reports
- Doxycycline: 176 reports
- Dupixent: 111 reports
- Effexor: 183 reports
- Enbrel: 2,488 reports
- Epipen: 180 reports
- Famotidine: 103 reports
- Fish oil: 246 reports
- Flexeril: 122 reports
- Flonase: 267 reports
- Flovent: 181 reports
- Fluconazole: 114 reports
- Fluoxetine: 148 reports
- Folic acid: 252 reports
- Forteo: 117 reports
- Fosamax: 366 reports
- Furosemide: 295 reports
- Gabapentin: 454 reports
- Gammagard: 139 reports
- Gilenya: 225 reports
- Heparin: 154 reports
- Hizentra: 272 reports
- Humalog: 171 reports
- Humira: 2,412 reports
- Hydramine: 851 reports
- Hydrochlorothiazide: 243 reports
- Hydroxychloroquine sulfate: 268 reports
- Hydroxyzine: 151 reports
- Ibu: 500 reports
- Ibuprofen: 498 reports
- Imbruvica: 155 reports
- Inflectra: 197 reports
- Keppra: 131 reports
- Klonopin: 105 reports
- Lansoprazole: 141 reports
- Lantus: 166 reports
- Lasix: 226 reports
- Leflunomide: 178 reports
- Letairis: 251 reports
- Levaquin: 139 reports
- Levothyroxine sodium: 137 reports
- Lexapro: 189 reports
- Lipitor: 289 reports
- Lisinopril: 520 reports
- Lopurin: 162 reports
- Loratadine: 134 reports
- Loraz: 227 reports
- Lorazepam: 226 reports
- Losartan: 226 reports
- Lyrica: 376 reports
- Magnesium: 187 reports
- Melatonin: 168 reports
- Meloxicam: 179 reports
- Metformin: 574 reports
- Methotrexate: 1,930 reports
- Methotrexate sodium: 216 reports
- Metoprolol tartrate: 106 reports
- Miralax: 135 reports
- Morphine: 292 reports
- Motrin: 447 reports
- Multivitamin: 255 reports
- Naprosyn: 394 reports
- Naproxen: 151 reports
- Nasonex: 203 reports
- Neurontin: 215 reports
- Nexium: 363 reports
- Norco: 123 reports
- Norvasc: 163 reports
- Ocrevus: 158 reports
- Omeprazole: 571 reports
- Ondansetron: 225 reports
- Opsumit: 258 reports
- Orencia: 184 reports
- Otezla: 238 reports
- Oxycodone: 194 reports
- Oxycontin: 145 reports
- Pantoprazole: 298 reports
- Paxil: 169 reports
- Pegasys: 108 reports
- Percocet: 204 reports
- Plaquenil: 556 reports
- Plavix: 129 reports
- Pomalyst: 117 reports
- Potassium: 144 reports
- Prednisolone: 120 reports
- Prednisone: 1,623 reports
- Premarin: 113 reports
- Prevacid: 210 reports
- Prilosec: 234 reports
- Proair hfa: 184 reports
- Profen: 498 reports
- Prolia: 179 reports
- Promethazine: 104 reports
- Protonix: 204 reports
- Prozac: 205 reports
- Pulmicort: 168 reports
- Ramipril: 111 reports
- Ranitidine: 199 reports
- Rebif: 111 reports
- Remicade: 346 reports
- Revatio: 139 reports
- Revlimid: 270 reports
- Ribavirin: 128 reports
- Rituxan: 205 reports
- Sandostatin: 208 reports
- Sandostatin lar: 182 reports
- Seroquel: 185 reports
- Sertraline: 195 reports
- Simponi: 222 reports
- Simvastatin: 301 reports
- Singulair: 733 reports
- Sodium chloride: 114 reports
- Soliris: 108 reports
- Spiriva: 254 reports
- Spironolactone: 101 reports
- Stelara: 234 reports
- Sulfasalazine: 153 reports
- Symbicort: 420 reports
- Synagis: 141 reports
- Synthroid: 589 reports
- Taltz: 113 reports
- Tecfidera: 141 reports
- Topamax: 191 reports
- Topiramate: 119 reports
- Tracleer: 125 reports
- Tramadol: 690 reports
- Tramadol hydrochloride: 148 reports
- Tylenol: 560 reports
- Tysabri: 615 reports
- Veletri: 145 reports
- Ventolin: 295 reports
- Vicodin: 104 reports
- Vioxx: 165 reports
- Vitamin b12: 301 reports
- Vitamin c: 397 reports
- Vitamin d: 758 reports
- Vitamin d3: 235 reports
- Vitamins: 444 reports
- Voltaren: 240 reports
- Wellbutrin: 185 reports
- Xanax: 290 reports
- Xarelto: 106 reports
- Xeljanz: 607 reports
- Xeljanz xr: 315 reports
- Xolair: 568 reports
- Xyrem: 282 reports
- Zantac: 237 reports
- Zide: 241 reports
- Zithromax: 160 reports
- Zocor: 110 reports
- Zofran: 474 reports
- Zoloft: 345 reports
- Zolpidem: 105 reports
- Zometa: 157 reports
- Zyrtec: 441 reports
All the drugs that are associated with Otitis:
- Otitis (2,370 drugs)
Common conditions associated with Otitis:
- Acid reflux: 276 reports
- Acupuncture and pain: 284 reports
- Acute sinusitis: 116 reports
- Adult hypothyroidism: 193 reports
- Agrypnia: 148 reports
- Alternative medicine - pain relief: 543 reports
- Ankylosing spondylitis: 429 reports
- Antidepressant therapy: 493 reports
- Anxiety: 312 reports
- Anxiety, apprehension, feeling uptight, jitters, stress, stress and anxiety, tension: 312 reports
- Anxiolytic therapy: 312 reports
- Arthritis: 170 reports
- Arthritis - rheumatoid: 3,974 reports
- Asthma: 882 reports
- Birth control: 156 reports
- Birth control and family planning: 151 reports
- Blood cholesterol abnormal: 378 reports
- Blood cholesterol increased: 365 reports
- Blood pressure - high: 586 reports
- Blood pressure increased: 616 reports
- Blood triglycerides abnormal: 365 reports
- Blood triglycerides increased: 377 reports
- Cataplexy: 144 reports
- Chronic asthma: 833 reports
- Chronic lymphocytic leukaemia: 145 reports
- Chronic obstructive airway disease: 126 reports
- Chronic obstructive pulmonary disease: 126 reports
- Colitis ulcerative: 237 reports
- Contraception: 156 reports
- Copd: 126 reports
- Crohn's disease: 865 reports
- Daytime sleep disorder: 228 reports
- Depression: 493 reports
- Diabetes: 265 reports
- Diabetes mellitus: 264 reports
- Diabetes mellitus management: 264 reports
- Diabetes mellitus non-insulin-dependent: 109 reports
- Disseminated lupus erythematosus: 107 reports
- Dm: 264 reports
- Dyslipidemia: 365 reports
- Dyssomnia: 145 reports
- Ear infection: 311 reports
- Epilepsy: 114 reports
- Feeling uptight: 312 reports
- Fibromyalgia: 142 reports
- Fibromyalgia syndrome: 147 reports
- Fibromyositis: 147 reports
- Fibrositis: 147 reports
- Foetal exposure during pregnancy: 268 reports
- Gastroesophageal reflux disease: 267 reports
- Gastro-oesophageal reflux disease: 276 reports
- Gastrooesophageal reflux disease: 267 reports
- Gerd: 276 reports
- Gerds: 282 reports
- Granulomatous ileocolitis: 802 reports
- Hbp: 616 reports
- Heartburn: 276 reports
- Heartburn - chronic: 267 reports
- Hepatitis c: 170 reports
- High blood cholesterol: 378 reports
- High blood cholesterol and triglycerides: 377 reports
- High blood pressure: 616 reports
- High cholesterol: 364 reports
- Htn: 616 reports
- Hypercholesterolaemia: 378 reports
- Hyperlipidemia: 377 reports
- Hypersensitivity: 190 reports
- Hypertension: 617 reports
- Hypertension aggravated: 670 reports
- Hypothyroidism: 193 reports
- Ileitis: 800 reports
- Ileitis aggravated: 867 reports
- Immunodeficiency common variable: 425 reports
- Inability to sleep: 148 reports
- Infection - ear: 198 reports
- Inflammatory bowel disease - crohn's disease: 1,118 reports
- Inflammatory bowel disease - ulcerative colitis: 276 reports
- Insomnia: 148 reports
- Insomnia concerns: 148 reports
- Insomnolence: 148 reports
- Jitters: 312 reports
- Jra: 136 reports
- Juvenile chronic polyarthritis: 136 reports
- Juvenile idiopathic arthritis: 130 reports
- Juvenile rheumatoid arthritis: 136 reports
- Lipid profile: 217 reports
- Lipid test: 378 reports
- Low thyroid: 193 reports
- Migraine: 130 reports
- Migraines: 123 reports
- Ms: 1,309 reports
- Ms hug: 1,309 reports
- Multiple myeloma: 418 reports
- Multiple sclerosis: 1,316 reports
- Multiple sclerosis aggravated: 1,316 reports
- Myxedema: 195 reports
- Narcolepsy: 238 reports
- Niddm: 199 reports
- Non-cardiac chest pain: 267 reports
- Osteoporosis: 423 reports
- Otitis: 179 reports
- Pain: 543 reports
- Pain exacerbated: 510 reports
- Plasma cell dyscrasia: 418 reports
- Plasma cell myeloma: 399 reports
- Pregnancy: 156 reports
- Primary pulmonary hypertension: 517 reports
- Psoriasis: 1,354 reports
- Psoriatic arthropathy: 1,042 reports
- Pulmonary arterial hypertension: 517 reports
- Pulmonary hypertension: 210 reports
- Ra: 3,974 reports
- Reflux: 276 reports
- Regional enteritis: 802 reports
- Relapsing-remitting multiple sclerosis: 165 reports
- Rheumatoid arthritis: 3,750 reports
- Rheumatoid spondylitis: 429 reports
- Seizure disorder: 110 reports
- Sinus infection: 116 reports
- Sinusitis: 111 reports
- Sleep aid: 148 reports
- Sleep disorder: 136 reports
- Sleep disorders: 143 reports
- Sleeping: 148 reports
- Sleeping difficulty: 148 reports
- Sleep issues: 148 reports
- Sleep - too much: 143 reports
- Spondylitis: 429 reports
- Stress: 312 reports
- Stress and anxiety: 295 reports
- Systemic lupus erythematosus: 107 reports
- Tension: 312 reports
- Thin bones: 393 reports
- Type 2 diabetes: 198 reports
- Type 2 diabetes mellitus: 192 reports
- Uc: 276 reports
- Ulcerative colitis: 276 reports
- Under active thyroid: 195 reports
- Under active thyroids: 193 reports
- Vitamin supplementation: 104 reports
- Wakefulness: 148 reports
All the conditions that are associated with Otitis:
- Otitis (1,628 conditions)
How the study uses the data?
The study uses data from the FDA. It is based on cyclobenzaprine hydrochloride (the active ingredients of Flexeril) and Flexeril (the brand name). Other drugs that have the same active ingredients (e.g. generic drugs) are not considered. Dosage of drugs is not considered in the study.
Who is eHealthMe?
With medical big data and proven AI algorithms, eHealthMe provides a platform for everyone to run phase IV clinical trials. We study millions of patients and 5,000 more each day. Results of our real-world drug study have been referenced on 600+ medical publications, including The Lancet, Mayo Clinic Proceedings, and Nature. Our analysis results are available to researchers, health care professionals, patients (testimonials), and software developers (open API).
WARNING, DISCLAIMER, USE FOR PUBLICATION
WARNING: Please DO NOT STOP MEDICATIONS without first consulting a physician since doing so could be hazardous to your health.
DISCLAIMER: All material available on eHealthMe.com is for informational purposes only, and is not a substitute for medical advice, diagnosis, or treatment provided by a qualified healthcare provider. All information is observation-only. Our phase IV clinical studies alone cannot establish cause-effect relationship. Different individuals may respond to medication in different ways. Every effort has been made to ensure that all information is accurate, up-to-date, and complete, but no guarantee is made to that effect. The use of the eHealthMe site and its content is at your own risk.
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