Ibuprofen and Scleroderma renal crisis - a phase IV clinical study of FDA data

Summary:

Scleroderma renal crisis is reported as a side effect among people who take Ibuprofen (ibuprofen), especially for people who are male, 50-59 old, also take Colchicine, and have Pleuropericarditis.

The phase IV clinical study analyzes which people have Scleroderma renal crisis when taking Ibuprofen. It is created by eHealthMe based on reports of 239,218 people who have side effects when taking Ibuprofen from the FDA, and is updated regularly.

What is Ibuprofen?

Ibuprofen has active ingredients of ibuprofen. It is often used in pain. eHealthMe is studying from 245,270 Ibuprofen users. Check the latest studies of Ibuprofen.

What is Scleroderma renal crisis?

Scleroderma renal crisis (malignant hypertension develops and causes acute renal failure was once a common cause of death) is found to be associated with 33 drugs and 72 conditions by eHealthMe. Check the latest studies of Scleroderma renal crisis.

On Aug, 10, 2026

239,218 people reported to have side effects when taking Ibuprofen.
Among them, 33 people (0.01%) have Scleroderma renal crisis.

Could Ibuprofen cause Scleroderma renal crisis?

Among these 33 people:

What is the gender of people who have Scleroderma renal crisis when taking Ibuprofen? *

female: 0.0 %
male: 100 %

What is the age of people who have Scleroderma renal crisis when taking Ibuprofen? *

What are other drugs people take besides Ibuprofen? *

Pantoprazole: 18 people, 54.55%
Colchicine: 18 people, 54.55%
Amlodipine: 9 people, 27.27%
Hydroxychloroquine Sulfate: 6 people, 18.18%
Captopril: 4 people, 12.12%

What are other side effects people have besides Scleroderma renal crisis? *

Thrombotic Microangiopathy (a pathology that results in thrombosis in capillaries and arterioles, due to an endothelial injury): 13 people, 39.39%
Hypertensive Emergency: 7 people, 21.21%
Posterior Reversible Encephalopathy Syndrome (posterior reversible encephalopathy syndrome (pres), also known as reversible posterior leukoencephalopathy syndrome (rpls), is a syndrome characterized by headache, confusion, seizures and visual loss): 6 people, 18.18%
Respiratory Distress (difficulty in breathing): 5 people, 15.15%
Microangiopathic Haemolytic Anaemia (anaemia due to inability of bone marrow to compensate the premature destruction of red blood cells): 4 people, 12.12%
Acute Kidney Failure: 4 people, 12.12%
Fatigue (feeling of tiredness): 3 people, 9.09%
Malaise (a feeling of general discomfort or uneasiness): 2 people, 6.06%
Drug Ineffective: 2 people, 6.06%
Rales (an abnormal respiratory sound characterized by fine crackles): 1 person, 3.03%

What are the existing conditions these people have? *

Pleuropericarditis (inflammation of the pleura and pericardium): 8 people, 24.24%
Gastric Ulcer (stomach ulcer): 3 people, 9.09%
Chronic Obstructive Pulmonary Disease (a progressive disease that makes it hard to breathe): 3 people, 9.09%
High Blood Pressure: 2 people, 6.06%
Pain Of Skin: 1 person, 3.03%

* Approximation only. Some reports may have incomplete information.

Do you take Ibuprofen and have Scleroderma renal crisis?

- Check whether Scleroderma renal crisis is associated with a drug or a condition
- Predict drug outcomes for up to one year with AI
- Get an AI agent to monitor your drugs continuously

Related studies:

Effectiveness of, long term effects of, and alternative drugs to Ibuprofen:

Ibuprofen (245,270 reports)

Browse all side effects of Ibuprofen:

a b c d e f g h i j k l m n o p q r s t u v w x y z

Browse all the drugs that are associated with Scleroderma renal crisis:

Scleroderma renal crisis (33 drugs)

Browse all the conditions that are associated with Scleroderma renal crisis:

Scleroderma renal crisis (72 conditions)

Related publications that referenced our studies

Moslim MA, Sodeman TC, Nawras AT, "A Case of Suggested Ibuprofen-Induced Acute Pancreatitis", American journal of therapeutics, 2016 Nov .
Moslim MA, Sodeman TC, Nawras AT, "A Case of Suggested Ibuprofen-Induced Acute Pancreatitis", American journal of therapeutics, 2016 Nov .

How the study uses the data?

The study uses data from the FDA. It is based on ibuprofen (the active ingredients of Ibuprofen) and Ibuprofen (the brand name). Other drugs that have the same active ingredients (e.g. generic drugs) are not considered. Dosage of drugs is not considered in the study.

How to use the study?

DO NOT STOP MEDICATIONS without first consulting your doctor. If there are any serious or long term adverse effects discovered in the study, discuss the study with your doctor to ensure that proper medication management will be in place if applicable.

Who is eHealthMe?

With medical big data and proven AI/ML algorithms, eHealthMe provides a platform for everyone to run phase IV clinical trials. We study millions of patients and 5,000 more each day. Results of our real-world drug study have been referenced on 800+ peer-reviewed medical publications, including The Lancet, Mayo Clinic Proceedings, and Nature. Our analysis results are available to researchers, health care professionals, patients (testimonials), and software developers (open API).

WARNING, DISCLAIMER, USE FOR PUBLICATION

WARNING: Please DO NOT STOP MEDICATIONS without first consulting a physician since doing so could be hazardous to your health.

DISCLAIMER: All material available on eHealthMe.com is for informational purposes only, and is not a substitute for medical advice, diagnosis, or treatment provided by a qualified healthcare provider. All information is observation-only. Our phase IV clinical studies alone cannot establish cause-effect relationship. Different individuals may respond to medication in different ways. Every effort has been made to ensure that all information is accurate, up-to-date, and complete, but no guarantee is made to that effect. The use of the eHealthMe site and its content is at your own risk.

If you use this eHealthMe study on publication, please acknowledge it with a citation: study title, URL, accessed date.