Imodium and Gallbladder operation - a phase IV clinical study of FDA data

Summary:

Gallbladder operation is reported as a side effect among people who take Imodium (loperamide hydrochloride), especially for people who are female, 60+ old, have been taking the drug for < 1 month also take Requip, and have Indigestion.

The phase IV clinical study analyzes which people have Gallbladder operation when taking Imodium. It is created by eHealthMe based on reports of 44,210 people who have side effects when taking Imodium from the FDA, and is updated regularly.

What is Imodium?

Imodium has active ingredients of loperamide hydrochloride. It is often used in diarrhea. eHealthMe is studying from 45,092 Imodium users. Check the latest studies of Imodium.

What is Gallbladder operation?

Gallbladder operation is found to be associated with 360 drugs and 763 conditions by eHealthMe. Check the latest studies of Gallbladder operation.

On Jan, 25, 2026

44,210 people reported to have side effects when taking Imodium.
Among them, 17 people (0.04%) have Gallbladder operation.

Could Imodium cause Gallbladder operation?

Among these 17 people:

How long have people been on Imodium when they have Gallbladder operation? *

What is the gender of people who have Gallbladder operation when taking Imodium? *

female: 64.71 %
male: 35.29 %

What is the age of people who have Gallbladder operation when taking Imodium? *

What are other drugs people take besides Imodium? *

Zejula: 4 people, 23.53%
Nexium: 4 people, 23.53%
Ondansetron: 4 people, 23.53%
Requip: 4 people, 23.53%
Detrol: 3 people, 17.65%
Ativan: 3 people, 17.65%
Cymbalta: 3 people, 17.65%
Promethazine Hydrochloride: 2 people, 11.76%
Symbicort: 2 people, 11.76%
Humulin R: 2 people, 11.76%

What are other side effects people have besides Gallbladder operation? *

Weakness: 5 people, 29.41%
Fatigue (feeling of tiredness): 5 people, 29.41%
Dizziness: 4 people, 23.53%
Depression: 4 people, 23.53%
Nausea (feeling of having an urge to vomit): 4 people, 23.53%
Headache (pain in head): 4 people, 23.53%
Full Blood Count Abnormal: 4 people, 23.53%
Indigestion: 4 people, 23.53%
Constipation: 4 people, 23.53%
Blood Glucose Increased: 4 people, 23.53%

What are the existing conditions these people have? *

Ovarian Cancer (cancer of ovary): 4 people, 23.53%
Indigestion: 4 people, 23.53%
Psoriasis (immune-mediated disease that affects the skin): 2 people, 11.76%
Diabetes: 2 people, 11.76%
Thyroid Cancer: 1 person, 5.88%
Rheumatoid Arthritis (a chronic progressive disease causing inflammation in the joints): 1 person, 5.88%
Primary Pulmonary Hypertension (primary high blood pressure that affects the arteries in the lungs and the right side of your heart): 1 person, 5.88%
Dementia (madness): 1 person, 5.88%
Coronary Heart Disease (narrowing or blockage of the coronary arteries): 1 person, 5.88%
Constipation: 1 person, 5.88%

* Approximation only. Some reports may have incomplete information.

Do you take Imodium and have Gallbladder operation?

- Check whether Gallbladder operation is associated with a drug or a condition
- Predict drug outcomes for up to one year with AI
- Get an AI agent to monitor your drugs continuously

Related studies:

Effectiveness of, long term effects of, and alternative drugs to Imodium:

Imodium (45,092 reports)

Browse all side effects of Imodium:

a b c d e f g h i j k l m n o p q r s t u v w x y z

Browse all the drugs that are associated with Gallbladder operation:

Gallbladder operation (360 drugs)

Browse all the conditions that are associated with Gallbladder operation:

Gallbladder operation (763 conditions)

How the study uses the data?

The study uses data from the FDA. It is based on loperamide hydrochloride (the active ingredients of Imodium) and Imodium (the brand name). Other drugs that have the same active ingredients (e.g. generic drugs) are not considered. Dosage of drugs is not considered in the study.

How to use the study?

DO NOT STOP MEDICATIONS without first consulting your doctor. If there are any serious or long term adverse effects discovered in the study, discuss the study with your doctor to ensure that proper medication management will be in place if applicable.

Who is eHealthMe?

With medical big data and proven AI/ML algorithms, eHealthMe provides a platform for everyone to run phase IV clinical trials. We study millions of patients and 5,000 more each day. Results of our real-world drug study have been referenced on 800+ peer-reviewed medical publications, including The Lancet, Mayo Clinic Proceedings, and Nature. Our analysis results are available to researchers, health care professionals, patients (testimonials), and software developers (open API).

WARNING, DISCLAIMER, USE FOR PUBLICATION

WARNING: Please DO NOT STOP MEDICATIONS without first consulting a physician since doing so could be hazardous to your health.

DISCLAIMER: All material available on eHealthMe.com is for informational purposes only, and is not a substitute for medical advice, diagnosis, or treatment provided by a qualified healthcare provider. All information is observation-only. Our phase IV clinical studies alone cannot establish cause-effect relationship. Different individuals may respond to medication in different ways. Every effort has been made to ensure that all information is accurate, up-to-date, and complete, but no guarantee is made to that effect. The use of the eHealthMe site and its content is at your own risk.

If you use this eHealthMe study on publication, please acknowledge it with a citation: study title, URL, accessed date.