Implanon and Musculoskeletal stiffness - a phase IV clinical study of FDA data

Summary:

Musculoskeletal stiffness is reported as a side effect among people who take Implanon (etonogestrel), especially for people who are female, 20-29 old, have been taking the drug for < 1 month also take Cotrim, and have Lupus nephritis.

The phase IV clinical study analyzes which people have Musculoskeletal stiffness when taking Implanon. It is created by eHealthMe based on reports of 11,921 people who have side effects when taking Implanon from the FDA, and is updated regularly.

What is Implanon?

Implanon has active ingredients of etonogestrel. It is often used in birth control. eHealthMe is studying from 12,479 Implanon users. Check the latest studies of Implanon.

What is Musculoskeletal stiffness?

Musculoskeletal stiffness (stiffness of the body's muscles, joints, tendons, ligaments and nerves) is found to be associated with 1,960 drugs and 1,916 conditions by eHealthMe. Check the latest studies of Musculoskeletal stiffness.

On Jul, 16, 2026

11,921 people reported to have side effects when taking Implanon.
Among them, 11 people (0.09%) have Musculoskeletal stiffness.

Could Implanon cause Musculoskeletal stiffness?

Among these 11 people:

How long have people been on Implanon when they have Musculoskeletal stiffness? *

What is the gender of people who have Musculoskeletal stiffness when taking Implanon? *

female: 100 %
male: 0.0 %

What is the age of people who have Musculoskeletal stiffness when taking Implanon? *

What are other drugs people take besides Implanon? *

What are other side effects people have besides Musculoskeletal stiffness? *

Paraesthesia (sensation of tingling, tickling, prickling, pricking, or burning of a person's skin with no apparent long-term physical effect): 3 people, 27.27%
Hair Loss: 3 people, 27.27%
Pain In Extremity: 3 people, 27.27%
Fever: 2 people, 18.18%
Bone Pain: 2 people, 18.18%
Headache (pain in head): 2 people, 18.18%
Device Dislocation: 2 people, 18.18%
Muscle Aches (muscle pain): 2 people, 18.18%
Pain: 2 people, 18.18%
Weakness: 2 people, 18.18%

What are the existing conditions these people have? *

Menstruation Irregular: 1 person, 9.09%
Lupus Nephritis (a chronic inflammatory autoimmune disorder that may affect kidney tissue): 1 person, 9.09%

* Approximation only. Some reports may have incomplete information.

Do you take Implanon and have Musculoskeletal stiffness?

- Check whether Musculoskeletal stiffness is associated with a drug or a condition
- Predict drug outcomes for up to one year with AI
- Get an AI agent to monitor your drugs continuously

Related studies:

Effectiveness of, long term effects of, and alternative drugs to Implanon:

Implanon (12,479 reports)

Browse all side effects of Implanon:

a b c d e f g h i j k l m n o p q r s t u v w x y z

Browse all the drugs that are associated with Musculoskeletal stiffness:

Musculoskeletal stiffness (1,960 drugs)

Browse all the conditions that are associated with Musculoskeletal stiffness:

Musculoskeletal stiffness (1,916 conditions)

How the study uses the data?

The study uses data from the FDA. It is based on etonogestrel (the active ingredients of Implanon) and Implanon (the brand name). Other drugs that have the same active ingredients (e.g. generic drugs) are not considered. Dosage of drugs is not considered in the study.

How to use the study?

DO NOT STOP MEDICATIONS without first consulting your doctor. If there are any serious or long term adverse effects discovered in the study, discuss the study with your doctor to ensure that proper medication management will be in place if applicable.

Who is eHealthMe?

With medical big data and proven AI/ML algorithms, eHealthMe provides a platform for everyone to run phase IV clinical trials. We study millions of patients and 5,000 more each day. Results of our real-world drug study have been referenced on 800+ peer-reviewed medical publications, including The Lancet, Mayo Clinic Proceedings, and Nature. Our analysis results are available to researchers, health care professionals, patients (testimonials), and software developers (open API).

WARNING, DISCLAIMER, USE FOR PUBLICATION

WARNING: Please DO NOT STOP MEDICATIONS without first consulting a physician since doing so could be hazardous to your health.

DISCLAIMER: All material available on eHealthMe.com is for informational purposes only, and is not a substitute for medical advice, diagnosis, or treatment provided by a qualified healthcare provider. All information is observation-only. Our phase IV clinical studies alone cannot establish cause-effect relationship. Different individuals may respond to medication in different ways. Every effort has been made to ensure that all information is accurate, up-to-date, and complete, but no guarantee is made to that effect. The use of the eHealthMe site and its content is at your own risk.

If you use this eHealthMe study on publication, please acknowledge it with a citation: study title, URL, accessed date.