Indocin and Anhedonia - a phase IV clinical study of FDA data

Summary:

Anhedonia is reported as a side effect among people who take Indocin (indomethacin), especially for people who are male, 60+ old, have been taking the drug for < 1 month also take Vancomycin, and have Metastases to bone.

The phase IV clinical study analyzes which people have Anhedonia when taking Indocin. It is created by eHealthMe based on reports of 4,328 people who have side effects when taking Indocin from the FDA, and is updated regularly.

What is Indocin?

Indocin has active ingredients of indomethacin. It is often used in gout. eHealthMe is studying from 4,559 Indocin users. Check the latest studies of Indocin.

What is Anhedonia?

Anhedonia (inability to experience pleasure from activities usually found enjoyable) is found to be associated with 1,509 drugs and 1,275 conditions by eHealthMe. Check the latest studies of Anhedonia.

On Jul, 15, 2026

4,328 people reported to have side effects when taking Indocin.
Among them, 66 people (1.52%) have Anhedonia.

Among these 66 people:

How long have people been on Indocin when they have Anhedonia? *

What is the gender of people who have Anhedonia when taking Indocin? *

female: 18.18 %
male: 81.82 %

What is the age of people who have Anhedonia when taking Indocin? *

What are other drugs people take besides Indocin? *

What are other side effects people have besides Anhedonia? *

Stress And Anxiety: 61 people, 92.42%
Injury: 36 people, 54.55%
Acute Kidney Failure: 35 people, 53.03%
Emotional Distress: 33 people, 50.00%
Osteonecrosis Of Jaw (death of bone of jaw): 24 people, 36.36%
Dyspnea (difficult or laboured breathing): 24 people, 36.36%
Joint Pain: 22 people, 33.33%
Fear: 22 people, 33.33%
Neuropathy Peripheral (surface nerve damage): 22 people, 33.33%
Back Pain: 21 people, 31.82%

What are the existing conditions these people have? *

Metastases To Bone (cancer spreads to bone): 9 people, 13.64%
Metastases To Prostate (cancer spreads to prostate): 7 people, 10.61%
High Blood Pressure: 7 people, 10.61%
Lung Cancer Metastatic (lung cancer spreads to other parts): 7 people, 10.61%
Neoplasm Malignant (cancer tumour): 7 people, 10.61%
Sleep Disorder: 4 people, 6.06%
Pulmonary Embolism (blockage of the main artery of the lung): 4 people, 6.06%
Pneumonia: 3 people, 4.55%
Bronchitis (inflammation of the mucous membrane in the bronchial tubes): 3 people, 4.55%
Chest Pain: 3 people, 4.55%

* Approximation only. Some reports may have incomplete information.

Do you take Indocin and have Anhedonia?

- Check whether Anhedonia is associated with a drug or a condition
- Predict drug outcomes for up to one year with AI
- Get an AI agent to monitor your drugs continuously

Related studies:

Effectiveness of, long term effects of, and alternative drugs to Indocin:

Indocin (4,559 reports)

Anhedonia treatments and more:

Anhedonia (51,943 reports)

Browse all side effects of Indocin:

a b c d e f g h i j k l m n o p q r s t u v w x y z

Browse all the drugs that are associated with Anhedonia:

Anhedonia (1,509 drugs)

Browse all the conditions that are associated with Anhedonia:

Anhedonia (1,275 conditions)

Related publications that referenced our studies

Mantarro S, Tuccori M, Pasqualetti G, Tognini S, Montagnani S, Monzani F, Blandizzi C, "Acute portal vein thrombosis precipitated by indomethacin in a HCV-positive elderly patient", BMC geriatrics, 2012 Nov .
Mantarro S, Tuccori M, Pasqualetti G, Tognini S, Montagnani S, Monzani F, Blandizzi C, "Acute portal vein thrombosis precipitated by indomethacin in a HCV-positive elderly patient", BMC geriatrics, 2012 Nov .

How the study uses the data?

The study uses data from the FDA. It is based on indomethacin (the active ingredients of Indocin) and Indocin (the brand name). Other drugs that have the same active ingredients (e.g. generic drugs) are not considered. Dosage of drugs is not considered in the study.

How to use the study?

DO NOT STOP MEDICATIONS without first consulting your doctor. If there are any serious or long term adverse effects discovered in the study, discuss the study with your doctor to ensure that proper medication management will be in place if applicable.

Who is eHealthMe?

With medical big data and proven AI/ML algorithms, eHealthMe provides a platform for everyone to run phase IV clinical trials. We study millions of patients and 5,000 more each day. Results of our real-world drug study have been referenced on 800+ peer-reviewed medical publications, including The Lancet, Mayo Clinic Proceedings, and Nature. Our analysis results are available to researchers, health care professionals, patients (testimonials), and software developers (open API).

WARNING, DISCLAIMER, USE FOR PUBLICATION

WARNING: Please DO NOT STOP MEDICATIONS without first consulting a physician since doing so could be hazardous to your health.

DISCLAIMER: All material available on eHealthMe.com is for informational purposes only, and is not a substitute for medical advice, diagnosis, or treatment provided by a qualified healthcare provider. All information is observation-only. Our phase IV clinical studies alone cannot establish cause-effect relationship. Different individuals may respond to medication in different ways. Every effort has been made to ensure that all information is accurate, up-to-date, and complete, but no guarantee is made to that effect. The use of the eHealthMe site and its content is at your own risk.

If you use this eHealthMe study on publication, please acknowledge it with a citation: study title, URL, accessed date.