Lamictal and Presyncope - a phase IV clinical study of FDA data

Summary:

Presyncope is reported as a side effect among people who take Lamictal (lamotrigine), especially for people who are female, 50-59 old, have been taking the drug for 2 - 5 years also take Wellbutrin, and have Depression.

The phase IV clinical study analyzes which people have Presyncope when taking Lamictal. It is created by eHealthMe based on reports of 74,218 people who have side effects when taking Lamictal from the FDA, and is updated regularly.

What is Lamictal?

Lamictal has active ingredients of lamotrigine. It is often used in bipolar disorder. eHealthMe is studying from 82,629 Lamictal users. Check the latest studies of Lamictal.

What is Presyncope?

Presyncope is found to be associated with 1,357 drugs and 1,286 conditions by eHealthMe. Check the latest studies of Presyncope.

eHealthMe: drug outcomes in the real world

eHealthMe runs one of the largest post-marketing drug safety studies in the world. We study millions of patients and 5,000 more each day. Our data-driven phase IV clinical trials have been referenced on 800+ peer-reviewed medical publications including The Lancet, Mayo Clinic Proceedings, and Nature. Tools to study our phase IV findings are available to the public, anonymous and free >>>.

On Aug, 31, 2026

74,218 people reported to have side effects when taking Lamictal.
Among them, 79 people (0.11%) have Presyncope.

Among these 79 people:

How long have people been on Lamictal when they have Presyncope? *

What is the gender of people who have Presyncope when taking Lamictal? *

female: 79.03 %
male: 20.97 %

What is the age of people who have Presyncope when taking Lamictal? *

What are other drugs people take besides Lamictal? *

What are other side effects people have besides Presyncope? *

Dizziness: 32 people, 40.51%
Fatigue (feeling of tiredness): 17 people, 21.52%
Chest Pain: 16 people, 20.25%
Hypotension (abnormally low blood pressure): 15 people, 18.99%
Dyspnea (difficult or laboured breathing): 14 people, 17.72%
Nausea (feeling of having an urge to vomit): 14 people, 17.72%
Stress And Anxiety: 14 people, 17.72%
Pain: 13 people, 16.46%
Weakness: 12 people, 15.19%
Depression: 11 people, 13.92%

What are the existing conditions these people have? *

Depression: 12 people, 15.19%
High Blood Pressure: 11 people, 13.92%
Osteopenia (a condition where bone mineral density is lower than normal): 8 people, 10.13%
Osteoporosis (bones weak and more likely to break): 8 people, 10.13%
Arthritis (form of joint disorder that involves inflammation of one or more joints): 8 people, 10.13%
Seizures (abnormal excessive or synchronous neuronal activity in the brain): 8 people, 10.13%
Pain: 7 people, 8.86%
Insomnia (sleeplessness): 6 people, 7.59%
Hypothyroidism (abnormally low activity of the thyroid gland, resulting in retardation of growth and mental development): 5 people, 6.33%
Panic Disorder: 5 people, 6.33%

* Approximation only. Some reports may have incomplete information.

Do you take Lamictal and have Presyncope?

- Check whether Presyncope is associated with a drug or a condition
- Predict drug outcomes for up to one year with AI
- Get an AI agent to monitor your drugs continuously

Related studies:

Effectiveness of, long term effects of, and alternative drugs to Lamictal:

Lamictal (82,629 reports)

Presyncope treatments and more:

Presyncope (26,156 reports)

Browse all side effects of Lamictal:

a b c d e f g h i j k l m n o p q r s t u v w x y z

Browse all the drugs that are associated with Presyncope:

Presyncope (1,357 drugs)

Browse all the conditions that are associated with Presyncope:

Presyncope (1,286 conditions)

Related publications that referenced our studies

Alonso-Navarro H, Montes JM, Plaza-Nieto JF, Jiménez-Jiménez FJ, "Cataplexy Possibly Associated With Lamotrigine", Journal of clinical psychopharmacology, 2016 Aug .
Gupta MC, Khanna J, Mathur R, Mittal N, "Lamotrigine-induced fulminant hepatic failure: an unusual presentation", IMSEAR, 2015 Jan .
Alonso-Navarro H, Montes JM, Plaza-Nieto JF, Jiménez-Jiménez FJ, "Cataplexy Possibly Associated With Lamotrigine", Journal of clinical psychopharmacology, 2016 Aug .
Gupta MC, Khanna J, Mathur R, Mittal N, "Lamotrigine-induced fulminant hepatic failure: an unusual presentation", IMSEAR, 2015 Jan .

How the study uses the data?

The study uses data from the FDA. It is based on lamotrigine (the active ingredients of Lamictal) and Lamictal (the brand name). Other drugs that have the same active ingredients (e.g. generic drugs) are not considered. Dosage of drugs is not considered in the study.

How to use the study?

DO NOT STOP MEDICATIONS without first consulting your doctor. If there are any serious or long term adverse effects discovered in the study, discuss the study with your doctor to ensure that proper medication management will be in place if applicable.

Who is eHealthMe?

With medical big data and proven AI/ML algorithms, eHealthMe provides a platform for everyone to run phase IV clinical trials. We study millions of patients and 5,000 more each day. Results of our real-world drug study have been referenced on 800+ peer-reviewed medical publications, including The Lancet, Mayo Clinic Proceedings, and Nature. Our analysis results are available to researchers, health care professionals, patients (testimonials), and software developers (open API).

WARNING, DISCLAIMER, USE FOR PUBLICATION

WARNING: Please DO NOT STOP MEDICATIONS without first consulting a physician since doing so could be hazardous to your health.

DISCLAIMER: All material available on eHealthMe.com is for informational purposes only, and is not a substitute for medical advice, diagnosis, or treatment provided by a qualified healthcare provider. All information is observation-only. Our phase IV clinical studies alone cannot establish cause-effect relationship. Different individuals may respond to medication in different ways. Every effort has been made to ensure that all information is accurate, up-to-date, and complete, but no guarantee is made to that effect. The use of the eHealthMe site and its content is at your own risk.

If you use this eHealthMe study on publication, please acknowledge it with a citation: study title, URL, accessed date.