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Lupron and Anaphylaxis - a phase IV clinical study of FDA data

Summary:

Anaphylaxis is reported as a side effect among people who take Lupron (leuprolide acetate), especially for people who are female, 60+ old, have been taking the drug for < 1 month also take Singulair, and have Cystic fibrosis.

The phase IV clinical study analyzes which people have Anaphylaxis when taking Lupron. It is created by eHealthMe based on reports of 41,483 people who have side effects when taking Lupron from the FDA, and is updated regularly.

What is Lupron?

Lupron has active ingredients of leuprolide acetate. It is often used in endometriosis. eHealthMe is studying from 42,122 Lupron users. Check the latest studies of Lupron.

What is Anaphylaxis?

Anaphylaxis (serious allergic reaction that is rapid in onset and may cause death) is found to be associated with 1,936 drugs and 2,858 conditions by eHealthMe. Check the latest studies of Anaphylaxis.

On Aug, 05, 2026

41,483 people reported to have side effects when taking Lupron.
Among them, 68 people (0.16%) have Anaphylaxis.

Could Lupron cause Anaphylaxis?

Among these 68 people:

How long have people been on Lupron when they have Anaphylaxis? *

  • < 1 month: 37.5 %
  • 1 - 6 months: 18.75 %
  • 6 - 12 months: 6.25 %
  • 1 - 2 years: 6.25 %
  • 2 - 5 years: 6.25 %
  • 5 - 10 years: 25.0 %
  • 10+ years: 0.0 %

What is the gender of people who have Anaphylaxis when taking Lupron? *

  • female: 62.5 %
  • male: 37.5 %

What is the age of people who have Anaphylaxis when taking Lupron? *

  • 0-1: 0.0 %
  • 2-9: 10.64 %
  • 10-19: 10.64 %
  • 20-29: 10.64 %
  • 30-39: 8.51 %
  • 40-49: 14.89 %
  • 50-59: 10.64 %
  • 60+: 34.04 %

What are other drugs people take besides Lupron? *

  1. Singulair: 8 people, 11.76%
  2. Xtandi: 6 people, 8.82%
  3. Sertraline: 6 people, 8.82%
  4. Trikafta: 5 people, 7.35%
  5. Aleve: 5 people, 7.35%
  6. Zenpep: 5 people, 7.35%
  7. Trulance: 5 people, 7.35%
  8. Miralax: 5 people, 7.35%
  9. Linzess: 5 people, 7.35%
  10. Prozac: 4 people, 5.88%

What are other side effects people have besides Anaphylaxis? *

  1. Dyspnea (difficult or laboured breathing): 7 people, 10.29%
  2. Fatigue (feeling of tiredness): 7 people, 10.29%
  3. Weight Increased: 6 people, 8.82%
  4. Skin Blushing/flushing (a sudden reddening of the face, neck): 6 people, 8.82%
  5. Chest Pain: 6 people, 8.82%
  6. Drug Hypersensitivity: 5 people, 7.35%
  7. Fluid Retention (an abnormal accumulation of fluid in the blood): 5 people, 7.35%
  8. Injection Site Discomfort: 5 people, 7.35%
  9. Rashes (redness): 5 people, 7.35%
  10. Hypotension (abnormally low blood pressure): 5 people, 7.35%

What are the existing conditions these people have? *

  1. Precocious Puberty: 5 people, 7.35%
  2. Cystic Fibrosis (disease of the secretary glands): 5 people, 7.35%
  3. Stress And Anxiety: 4 people, 5.88%
  4. Breast Cancer Female: 2 people, 2.94%
  5. Pain: 2 people, 2.94%
  6. Depressed Mood: 2 people, 2.94%
  7. Weight Increased: 1 person, 1.47%
  8. Hereditary Angioedema (recurrent episodes of severe swelling): 1 person, 1.47%
  9. Constipation: 1 person, 1.47%
  10. Diabetes: 1 person, 1.47%

* Approximation only. Some reports may have incomplete information.

Do you take Lupron and have Anaphylaxis?

- Check whether Anaphylaxis is associated with a drug or a condition
- Predict drug outcomes for up to one year with AI
- Get an AI agent to monitor your drugs continuously

Related studies:

Effectiveness of, long term effects of, and alternative drugs to Lupron:

Anaphylaxis treatments and more:

How severe was Anaphylaxis and when was it recovered:

Expand to all the drugs that have ingredients of leuprolide acetate:

Sub-studies by gender and age:

Female: 0-1 2-9 10-19 20-29 30-39 40-49 50-59 60+

Male: 0-1 2-9 10-19 20-29 30-39 40-49 50-59 60+

Browse all side effects of Lupron:

a b c d e f g h i j k l m n o p q r s t u v w x y z

Browse all the drugs that are associated with Anaphylaxis:

Browse all the conditions that are associated with Anaphylaxis:

Related publications that referenced our studies

How the study uses the data?

The study uses data from the FDA. It is based on leuprolide acetate (the active ingredients of Lupron) and Lupron (the brand name). Other drugs that have the same active ingredients (e.g. generic drugs) are not considered. Dosage of drugs is not considered in the study.

How to use the study?

DO NOT STOP MEDICATIONS without first consulting your doctor. If there are any serious or long term adverse effects discovered in the study, discuss the study with your doctor to ensure that proper medication management will be in place if applicable.

Who is eHealthMe?

With medical big data and proven AI/ML algorithms, eHealthMe provides a platform for everyone to run phase IV clinical trials. We study millions of patients and 5,000 more each day. Results of our real-world drug study have been referenced on 800+ peer-reviewed medical publications, including The Lancet, Mayo Clinic Proceedings, and Nature. Our analysis results are available to researchers, health care professionals, patients (testimonials), and software developers (open API).

WARNING, DISCLAIMER, USE FOR PUBLICATION

WARNING: Please DO NOT STOP MEDICATIONS without first consulting a physician since doing so could be hazardous to your health.

DISCLAIMER: All material available on eHealthMe.com is for informational purposes only, and is not a substitute for medical advice, diagnosis, or treatment provided by a qualified healthcare provider. All information is observation-only. Our phase IV clinical studies alone cannot establish cause-effect relationship. Different individuals may respond to medication in different ways. Every effort has been made to ensure that all information is accurate, up-to-date, and complete, but no guarantee is made to that effect. The use of the eHealthMe site and its content is at your own risk.

If you use this eHealthMe study on publication, please acknowledge it with a citation: study title, URL, accessed date.

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