Macrobid and Tenderness - a phase IV clinical study of FDA data

Summary:

Tenderness is reported as a side effect among people who take Macrobid (nitrofurantoin; nitrofurantoin, macrocrystalline), especially for people who are female, 60+ old, have been taking the drug for < 1 month also take Flonase, and have Neoplasm malignant.

The phase IV clinical study analyzes which people have Tenderness when taking Macrobid. It is created by eHealthMe based on reports of 8,335 people who have side effects when taking Macrobid from the FDA, and is updated regularly.

What is Macrobid?

Macrobid has active ingredients of nitrofurantoin; nitrofurantoin, macrocrystalline. It is often used in urinary tract infection. eHealthMe is studying from 9,215 Macrobid users. Check the latest studies of Macrobid.

What is Tenderness?

Tenderness (pain or discomfort when an affected area is touched) is found to be associated with 1,045 drugs and 1,012 conditions by eHealthMe. Check the latest studies of Tenderness.

On Jul, 10, 2026

8,335 people reported to have side effects when taking Macrobid.
Among them, 44 people (0.53%) have Tenderness.

Among these 44 people:

How long have people been on Macrobid when they have Tenderness? *

What is the gender of people who have Tenderness when taking Macrobid? *

female: 100 %
male: 0.0 %

What is the age of people who have Tenderness when taking Macrobid? *

What are other drugs people take besides Macrobid? *

What are other side effects people have besides Tenderness? *

Pain: 32 people, 72.73%
Weakness: 30 people, 68.18%
Dyspnea (difficult or laboured breathing): 30 people, 68.18%
Headache (pain in head): 30 people, 68.18%
Deformity (disfigurement): 29 people, 65.91%
High Blood Pressure: 29 people, 65.91%
Joint Pain: 29 people, 65.91%
Osteoarthritis (a joint disease caused by cartilage loss in a joint): 28 people, 63.64%
Swallowing Difficulty: 28 people, 63.64%
Stress And Anxiety: 28 people, 63.64%

What are the existing conditions these people have? *

Metastases To Spine (cancer spreads to spine): 25 people, 56.82%
Calcium Deficiency (lack of calcium): 25 people, 56.82%
Neoplasm Malignant (cancer tumour): 25 people, 56.82%
Lung Neoplasm (tumour of lung): 24 people, 54.55%
Immunodeficiency Common Variable: 7 people, 15.91%
Metastases To Bone (cancer spreads to bone): 4 people, 9.09%
Breast Cancer: 3 people, 6.82%
Gastroesophageal Reflux Disease (a condition in which stomach contents leak backward from the stomach into the oesophagus): 3 people, 6.82%
Chest Pain: 2 people, 4.55%
Ankylosing Spondylitis (type of arthritis affecting the spine): 2 people, 4.55%

* Approximation only. Some reports may have incomplete information.

Do you take Macrobid and have Tenderness?

- Check whether Tenderness is associated with a drug or a condition
- Predict drug outcomes for up to one year with AI
- Get an AI agent to monitor your drugs continuously

Related studies:

Effectiveness of, long term effects of, and alternative drugs to Macrobid:

Macrobid (9,215 reports)

Tenderness treatments and more:

Tenderness (13,319 reports)

How severe was Tenderness and when was it recovered:

Tenderness in Macrobid

Expand to all the drugs that have ingredients of nitrofurantoin; nitrofurantoin, macrocrystalline:

Tenderness and drugs with ingredients of nitrofurantoin; nitrofurantoin, macrocrystalline

Sub-studies by gender and age:

Female: 0-1 2-9 10-19 20-29 30-39 40-49 50-59 60+

Male: 0-1 2-9 10-19 20-29 30-39 40-49 50-59 60+

Browse all side effects of Macrobid:

a b c d e f g h i j k l m n o p q r s t u v w x y z

Browse all the drugs that are associated with Tenderness:

Tenderness (1,045 drugs)

Browse all the conditions that are associated with Tenderness:

Tenderness (1,012 conditions)

How the study uses the data?

The study uses data from the FDA. It is based on nitrofurantoin; nitrofurantoin, macrocrystalline (the active ingredients of Macrobid) and Macrobid (the brand name). Other drugs that have the same active ingredients (e.g. generic drugs) are not considered. Dosage of drugs is not considered in the study.

How to use the study?

DO NOT STOP MEDICATIONS without first consulting your doctor. If there are any serious or long term adverse effects discovered in the study, discuss the study with your doctor to ensure that proper medication management will be in place if applicable.

Who is eHealthMe?

With medical big data and proven AI/ML algorithms, eHealthMe provides a platform for everyone to run phase IV clinical trials. We study millions of patients and 5,000 more each day. Results of our real-world drug study have been referenced on 800+ peer-reviewed medical publications, including The Lancet, Mayo Clinic Proceedings, and Nature. Our analysis results are available to researchers, health care professionals, patients (testimonials), and software developers (open API).

WARNING, DISCLAIMER, USE FOR PUBLICATION

WARNING: Please DO NOT STOP MEDICATIONS without first consulting a physician since doing so could be hazardous to your health.

DISCLAIMER: All material available on eHealthMe.com is for informational purposes only, and is not a substitute for medical advice, diagnosis, or treatment provided by a qualified healthcare provider. All information is observation-only. Our phase IV clinical studies alone cannot establish cause-effect relationship. Different individuals may respond to medication in different ways. Every effort has been made to ensure that all information is accurate, up-to-date, and complete, but no guarantee is made to that effect. The use of the eHealthMe site and its content is at your own risk.

If you use this eHealthMe study on publication, please acknowledge it with a citation: study title, URL, accessed date.