Naloxone and Multiple myeloma - a phase IV clinical study of FDA data

Summary:

Multiple myeloma is reported as a side effect among people who take Naloxone (naloxone hydrochloride), especially for people who are male, 60+ old, have been taking the drug for < 1 month also take Dexamethasone, and have Arteriosclerosis coronary artery.

The phase IV clinical study analyzes which people have Multiple myeloma when taking Naloxone. It is created by eHealthMe based on reports of 6,366 people who have side effects when taking Naloxone from the FDA, and is updated regularly.

What is Naloxone?

Naloxone has active ingredients of naloxone hydrochloride. eHealthMe is studying from 6,425 Naloxone users. Check the latest studies of Naloxone.

What is Multiple myeloma?

Multiple myeloma (cancer of the plasma cells) is found to be associated with 1,107 drugs and 1,404 conditions by eHealthMe. Check the latest studies of Multiple myeloma.

eHealthMe: drug outcomes in the real world

eHealthMe runs one of the largest post-marketing drug safety studies in the world. We study millions of patients and 5,000 more each day. Our data-driven phase IV clinical trials have been referenced on 800+ peer-reviewed medical publications including The Lancet, Mayo Clinic Proceedings, and Nature. Tools to study our phase IV findings are available to the public, anonymous and free >>>.



On Aug, 27, 2026

6,366 people reported to have side effects when taking Naloxone.
Among them, 24 people (0.38%) have Multiple myeloma.

Could Naloxone cause Multiple myeloma?

Among these 24 people:

How long have people been on Naloxone when they have Multiple myeloma? *

  • < 1 month: 100 %
  • 1 - 6 months: 0.0 %
  • 6 - 12 months: 0.0 %
  • 1 - 2 years: 0.0 %
  • 2 - 5 years: 0.0 %
  • 5 - 10 years: 0.0 %
  • 10+ years: 0.0 %

What is the gender of people who have Multiple myeloma when taking Naloxone? *

  • female: 5.26 %
  • male: 94.74 %

What is the age of people who have Multiple myeloma when taking Naloxone? *

  • 0-1: 0.0 %
  • 2-9: 0.0 %
  • 10-19: 0.0 %
  • 20-29: 0.0 %
  • 30-39: 0.0 %
  • 40-49: 0.0 %
  • 50-59: 11.76 %
  • 60+: 88.24 %

What are other drugs people take besides Naloxone? *

  1. Dexamethasone: 17 people, 70.83%
  2. Ondansetron: 16 people, 66.67%
  3. Acyclovir: 12 people, 50.00%
  4. Bisacodyl: 9 people, 37.50%
  5. Trospium Chloride: 8 people, 33.33%
  6. Edoxaban: 8 people, 33.33%
  7. Albuterol: 8 people, 33.33%
  8. Lenalidomide: 8 people, 33.33%
  9. Eplerenone: 8 people, 33.33%
  10. Prednisone: 8 people, 33.33%

What are other side effects people have besides Multiple myeloma? *

  1. Atrial Fibrillation/flutter (atrial fibrillation and flutter are abnormal heart rhythms in which the atria, or upper chambers of the heart, are out of sync with the ventricles): 8 people, 33.33%
  2. Heart Attack: 8 people, 33.33%
  3. Acute Kidney Failure: 5 people, 20.83%
  4. Anaemia (lack of blood): 5 people, 20.83%
  5. Nosebleed (bleeding from nose): 5 people, 20.83%
  6. Hypercalcaemia (elevated calcium (ca+) level in the blood): 3 people, 12.50%
  7. Sinusitis Fungal (fungal infection of sinus): 3 people, 12.50%
  8. Respiratory Tract Inflammation: 3 people, 12.50%
  9. Respiratory Distress (difficulty in breathing): 3 people, 12.50%
  10. Bladder Perforation (bladder trauma): 3 people, 12.50%

What are the existing conditions these people have? *

  1. Nausea (feeling of having an urge to vomit): 8 people, 33.33%
  2. Pain: 8 people, 33.33%
  3. Atherosclerosis (disorder of the arteries): 8 people, 33.33%
  4. Arteriosclerosis Coronary Artery (thickening and hardening of arteries- coronary artery): 8 people, 33.33%
  5. Sinusitis (inflammation of sinus): 3 people, 12.50%
  6. Sinusitis Fungal (fungal infection of sinus): 3 people, 12.50%
  7. Haemorrhage (bleeding): 3 people, 12.50%
  8. Gastroesophageal Reflux Disease (a condition in which stomach contents leak backward from the stomach into the oesophagus): 3 people, 12.50%
  9. White Blood Cell Count Abnormal: 3 people, 12.50%
  10. Prostatomegaly (enlargement of the prostate): 2 people, 8.33%

* Approximation only. Some reports may have incomplete information.

Do you take Naloxone and have Multiple myeloma?

- Check whether Multiple myeloma is associated with a drug or a condition
- Predict drug outcomes for up to one year with AI
- Get an AI agent to monitor your drugs continuously



Related studies:

Effectiveness of, long term effects of, and alternative drugs to Naloxone:

Multiple myeloma treatments and more:

How severe was Multiple myeloma and when was it recovered:

Expand to all the drugs that have ingredients of naloxone hydrochloride:

Sub-studies by gender and age:

Female: 0-1 2-9 10-19 20-29 30-39 40-49 50-59 60+

Male: 0-1 2-9 10-19 20-29 30-39 40-49 50-59 60+

Browse all side effects of Naloxone:

a b c d e f g h i j k l m n o p q r s t u v w x y z

Browse all the drugs that are associated with Multiple myeloma:

Browse all the conditions that are associated with Multiple myeloma:


How the study uses the data?

The study uses data from the FDA. It is based on naloxone hydrochloride (the active ingredients of Naloxone) and Naloxone (the brand name). Other drugs that have the same active ingredients (e.g. generic drugs) are not considered. Dosage of drugs is not considered in the study.

How to use the study?

DO NOT STOP MEDICATIONS without first consulting your doctor. If there are any serious or long term adverse effects discovered in the study, discuss the study with your doctor to ensure that proper medication management will be in place if applicable.

Who is eHealthMe?

With medical big data and proven AI/ML algorithms, eHealthMe provides a platform for everyone to run phase IV clinical trials. We study millions of patients and 5,000 more each day. Results of our real-world drug study have been referenced on 800+ peer-reviewed medical publications, including The Lancet, Mayo Clinic Proceedings, and Nature. Our analysis results are available to researchers, health care professionals, patients (testimonials), and software developers (open API).

WARNING, DISCLAIMER, USE FOR PUBLICATION

WARNING: Please DO NOT STOP MEDICATIONS without first consulting a physician since doing so could be hazardous to your health.

DISCLAIMER: All material available on eHealthMe.com is for informational purposes only, and is not a substitute for medical advice, diagnosis, or treatment provided by a qualified healthcare provider. All information is observation-only. Our phase IV clinical studies alone cannot establish cause-effect relationship. Different individuals may respond to medication in different ways. Every effort has been made to ensure that all information is accurate, up-to-date, and complete, but no guarantee is made to that effect. The use of the eHealthMe site and its content is at your own risk.

If you use this eHealthMe study on publication, please acknowledge it with a citation: study title, URL, accessed date.



Recent studies on eHealthMe: