Nicotine and Adrenal insufficiency - a phase IV clinical study of FDA data

Summary:

Adrenal insufficiency is reported as a side effect among people who take Nicotine (nicotine), especially for people who are male, 60+ old, have been taking the drug for 1 - 2 years also take Solu-Medrol, and have Nicotine dependence.

The phase IV clinical study analyzes which people have Adrenal insufficiency when taking Nicotine. It is created by eHealthMe based on reports of 20,079 people who have side effects when taking Nicotine from the FDA, and is updated regularly.

What is Nicotine?

Nicotine has active ingredients of nicotine. It is often used in quit smoking. eHealthMe is studying from 20,443 Nicotine users. Check the latest studies of Nicotine.

What is Adrenal insufficiency?

Adrenal insufficiency (a condition in which the adrenal glands do not produce adequate amounts of steroids) is found to be associated with 966 drugs and 1,094 conditions by eHealthMe. Check the latest studies of Adrenal insufficiency.

eHealthMe: drug outcomes in the real world

eHealthMe runs one of the largest post-marketing drug safety studies in the world. We study millions of patients and 5,000 more each day. Our data-driven phase IV clinical trials have been referenced on 800+ peer-reviewed medical publications including The Lancet, Mayo Clinic Proceedings, and Nature. Tools to study our phase IV findings are available to the public, anonymous and free >>>.

On Sep, 02, 2026

20,079 people reported to have side effects when taking Nicotine.
Among them, 17 people (0.08%) have Adrenal insufficiency.

Could Nicotine cause Adrenal insufficiency?

Among these 17 people:

How long have people been on Nicotine when they have Adrenal insufficiency? *

What is the gender of people who have Adrenal insufficiency when taking Nicotine? *

female: 17.65 %
male: 82.35 %

What is the age of people who have Adrenal insufficiency when taking Nicotine? *

What are other drugs people take besides Nicotine? *

What are other side effects people have besides Adrenal insufficiency? *

Fatigue (feeling of tiredness): 12 people, 70.59%
Dyspnea (difficult or laboured breathing): 11 people, 64.71%
Sinusitis (inflammation of sinus): 11 people, 64.71%
General Physical Health Deterioration (weak health status): 10 people, 58.82%
High Blood Cholesterol: 10 people, 58.82%
Memory Loss: 10 people, 58.82%
Weakness: 9 people, 52.94%
Rheumatoid Arthritis (a chronic progressive disease causing inflammation in the joints): 8 people, 47.06%
Mental Status Changes (general changes in brain function, such as confusion, amnesia (memory loss), loss of alertness, loss of orientation): 8 people, 47.06%
Osteoarthritis (a joint disease caused by cartilage loss in a joint): 8 people, 47.06%

What are the existing conditions these people have? *

Nicotine Dependence: 4 people, 23.53%
Sinusitis (inflammation of sinus): 3 people, 17.65%
The Flu (the flu is caused by an influenza virus): 3 people, 17.65%
Hepatocellular Carcinoma (liver cancer): 3 people, 17.65%
Adverse Event: 2 people, 11.76%
Psoriasis (immune-mediated disease that affects the skin): 2 people, 11.76%
Oropharyngeal Pain: 2 people, 11.76%
Lung Squamous Cell Carcinoma Stage Iii (lung cancer has spread to lymph nodes on the same side of the chest as the tumour. the lymph nodes with cancer are near the sternum (chest bone) or where the bronchus enters the lung): 1 person, 5.88%
Chronic Obstructive Pulmonary Disease (a progressive disease that makes it hard to breathe): 1 person, 5.88%
Constipation: 1 person, 5.88%

* Approximation only. Some reports may have incomplete information.

Do you take Nicotine and have Adrenal insufficiency?

- Check whether Adrenal insufficiency is associated with a drug or a condition
- Predict drug outcomes for up to one year with AI
- Get an AI agent to monitor your drugs continuously

Related studies:

Effectiveness of, long term effects of, and alternative drugs to Nicotine:

Nicotine (20,443 reports)

Browse all side effects of Nicotine:

a b c d e f g h i j k l m n o p q r s t u v w x y z

Browse all the drugs that are associated with Adrenal insufficiency:

Adrenal insufficiency (966 drugs)

Browse all the conditions that are associated with Adrenal insufficiency:

Adrenal insufficiency (1,094 conditions)

How the study uses the data?

The study uses data from the FDA. It is based on nicotine (the active ingredients of Nicotine) and Nicotine (the brand name). Other drugs that have the same active ingredients (e.g. generic drugs) are not considered. Dosage of drugs is not considered in the study.

How to use the study?

DO NOT STOP MEDICATIONS without first consulting your doctor. If there are any serious or long term adverse effects discovered in the study, discuss the study with your doctor to ensure that proper medication management will be in place if applicable.

Who is eHealthMe?

With medical big data and proven AI/ML algorithms, eHealthMe provides a platform for everyone to run phase IV clinical trials. We study millions of patients and 5,000 more each day. Results of our real-world drug study have been referenced on 800+ peer-reviewed medical publications, including The Lancet, Mayo Clinic Proceedings, and Nature. Our analysis results are available to researchers, health care professionals, patients (testimonials), and software developers (open API).

WARNING, DISCLAIMER, USE FOR PUBLICATION

WARNING: Please DO NOT STOP MEDICATIONS without first consulting a physician since doing so could be hazardous to your health.

DISCLAIMER: All material available on eHealthMe.com is for informational purposes only, and is not a substitute for medical advice, diagnosis, or treatment provided by a qualified healthcare provider. All information is observation-only. Our phase IV clinical studies alone cannot establish cause-effect relationship. Different individuals may respond to medication in different ways. Every effort has been made to ensure that all information is accurate, up-to-date, and complete, but no guarantee is made to that effect. The use of the eHealthMe site and its content is at your own risk.

If you use this eHealthMe study on publication, please acknowledge it with a citation: study title, URL, accessed date.