Pennsaid and Migraine aggravated - a phase IV clinical study of FDA data

Summary:

Migraine aggravated is reported as a side effect among people who take Pennsaid (diclofenac sodium), especially for people who are female, 60+ old, have been taking the drug for < 1 month also take Lyrica, and have Pain.

The phase IV clinical study analyzes which people have Migraine aggravated when taking Pennsaid. It is created by eHealthMe based on reports of 2,824 people who have side effects when taking Pennsaid from the FDA, and is updated regularly.

What is Pennsaid?

Pennsaid has active ingredients of diclofenac sodium. eHealthMe is studying from 2,849 Pennsaid users. Check the latest studies of Pennsaid.

What is Migraine aggravated?

Migraine aggravated (headache) is found to be associated with 1,621 drugs and 482 conditions by eHealthMe. Check the latest studies of Migraine aggravated.

On Jul, 19, 2026

2,824 people reported to have side effects when taking Pennsaid.
Among them, 22 people (0.78%) have Migraine aggravated.

Could Pennsaid cause Migraine aggravated?

Among these 22 people:

How long have people been on Pennsaid when they have Migraine aggravated? *

What is the gender of people who have Migraine aggravated when taking Pennsaid? *

female: 66.67 %
male: 33.33 %

What is the age of people who have Migraine aggravated when taking Pennsaid? *

What are other drugs people take besides Pennsaid? *

What are other side effects people have besides Migraine aggravated? *

Stress And Anxiety: 8 people, 36.36%
Joint Pain: 8 people, 36.36%
Pain In Extremity: 6 people, 27.27%
Muscle Spasms (muscle contraction): 6 people, 27.27%
Pain: 6 people, 27.27%
Insomnia (sleeplessness): 5 people, 22.73%
Neck Pain: 5 people, 22.73%
Peripheral Swelling: 5 people, 22.73%
Headache (pain in head): 5 people, 22.73%
High Blood Pressure: 5 people, 22.73%

What are the existing conditions these people have? *

Pain: 6 people, 27.27%
Joint Pain: 5 people, 22.73%
Fibromyalgia (a long-term condition which causes pain all over the body): 5 people, 22.73%
High Blood Cholesterol: 4 people, 18.18%
High Blood Pressure: 3 people, 13.64%
Gout (uric acid crystals building up in the body): 3 people, 13.64%
Gastroesophageal Reflux Disease (a condition in which stomach contents leak backward from the stomach into the oesophagus): 3 people, 13.64%
Narcolepsy (brain's inability to regulate sleep-wake cycles normally): 3 people, 13.64%
Neuropathy Peripheral (surface nerve damage): 3 people, 13.64%
Diabetic Neuropathy (neuropathic disorders that are associated with diabetes mellitus): 3 people, 13.64%

* Approximation only. Some reports may have incomplete information.

Do you take Pennsaid and have Migraine aggravated?

- Check whether Migraine aggravated is associated with a drug or a condition
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Related studies:

Effectiveness of, long term effects of, and alternative drugs to Pennsaid:

Pennsaid (2,849 reports)

Browse all side effects of Pennsaid:

a b c d e f g h i j k l m n o p q r s t u v w x y z

Browse all the drugs that are associated with Migraine aggravated:

Migraine aggravated (1,621 drugs)

Browse all the conditions that are associated with Migraine aggravated:

Migraine aggravated (482 conditions)

How the study uses the data?

The study uses data from the FDA. It is based on diclofenac sodium (the active ingredients of Pennsaid) and Pennsaid (the brand name). Other drugs that have the same active ingredients (e.g. generic drugs) are not considered. Dosage of drugs is not considered in the study.

How to use the study?

DO NOT STOP MEDICATIONS without first consulting your doctor. If there are any serious or long term adverse effects discovered in the study, discuss the study with your doctor to ensure that proper medication management will be in place if applicable.

Who is eHealthMe?

With medical big data and proven AI/ML algorithms, eHealthMe provides a platform for everyone to run phase IV clinical trials. We study millions of patients and 5,000 more each day. Results of our real-world drug study have been referenced on 800+ peer-reviewed medical publications, including The Lancet, Mayo Clinic Proceedings, and Nature. Our analysis results are available to researchers, health care professionals, patients (testimonials), and software developers (open API).

WARNING, DISCLAIMER, USE FOR PUBLICATION

WARNING: Please DO NOT STOP MEDICATIONS without first consulting a physician since doing so could be hazardous to your health.

DISCLAIMER: All material available on eHealthMe.com is for informational purposes only, and is not a substitute for medical advice, diagnosis, or treatment provided by a qualified healthcare provider. All information is observation-only. Our phase IV clinical studies alone cannot establish cause-effect relationship. Different individuals may respond to medication in different ways. Every effort has been made to ensure that all information is accurate, up-to-date, and complete, but no guarantee is made to that effect. The use of the eHealthMe site and its content is at your own risk.

If you use this eHealthMe study on publication, please acknowledge it with a citation: study title, URL, accessed date.