Prolia and Oestrogen deficiency - a phase IV clinical study of FDA data

Summary:

Oestrogen deficiency is reported as a side effect among people who take Prolia (denosumab), especially for people who are 60+ old, also take Calcium, and have Bone loss.

The phase IV clinical study analyzes which people have Oestrogen deficiency when taking Prolia. It is created by eHealthMe based on reports of 150,727 people who have side effects when taking Prolia from the FDA, and is updated regularly.

What is Prolia?

Prolia has active ingredients of denosumab. It is often used in osteoporosis. eHealthMe is studying from 151,388 Prolia users. Check the latest studies of Prolia.

What is Oestrogen deficiency?

Oestrogen deficiency (lack of estrogens) is found to be associated with 28 drugs and 128 conditions by eHealthMe. Check the latest studies of Oestrogen deficiency.

On Jul, 16, 2026

150,727 people reported to have side effects when taking Prolia.
Among them, 69 people (0.05%) have Oestrogen deficiency.

Could Prolia cause Oestrogen deficiency?

Among these 69 people:

What is the age of people who have Oestrogen deficiency when taking Prolia? *

What are other drugs people take besides Prolia? *

Calcium: 2 people, 2.90%

What are other side effects people have besides Oestrogen deficiency? *

Body Height Decreased: 40 people, 57.97%
Back Pain: 34 people, 49.28%
High Blood Pressure: 28 people, 40.58%
Hyperlipidaemia (presence of excess lipids in the blood): 20 people, 28.99%
Indigestion: 19 people, 27.54%
Mobility Decreased (ability to move is reduced): 19 people, 27.54%
Osteoarthritis (a joint disease caused by cartilage loss in a joint): 19 people, 27.54%
Weakness: 18 people, 26.09%
Rickets (softening of bones): 17 people, 24.64%
Depression: 16 people, 23.19%

What are the existing conditions these people have? *

Irritable Bowel Syndrome: 1 person, 1.45%
Immune System Disorder: 1 person, 1.45%
Breast Cancer: 1 person, 1.45%
Bone Loss: 1 person, 1.45%

* Approximation only. Some reports may have incomplete information.

Do you take Prolia and have Oestrogen deficiency?

- Check whether Oestrogen deficiency is associated with a drug or a condition
- Predict drug outcomes for up to one year with AI
- Get an AI agent to monitor your drugs continuously

Related studies:

Effectiveness of, long term effects of, and alternative drugs to Prolia:

Prolia (151,388 reports)

Browse all side effects of Prolia:

a b c d e f g h i j k l m n o p q r s t u v w x y z

Browse all the drugs that are associated with Oestrogen deficiency:

Oestrogen deficiency (28 drugs)

Browse all the conditions that are associated with Oestrogen deficiency:

Oestrogen deficiency (128 conditions)

How the study uses the data?

The study uses data from the FDA. It is based on denosumab (the active ingredients of Prolia) and Prolia (the brand name). Other drugs that have the same active ingredients (e.g. generic drugs) are not considered. Dosage of drugs is not considered in the study.

How to use the study?

DO NOT STOP MEDICATIONS without first consulting your doctor. If there are any serious or long term adverse effects discovered in the study, discuss the study with your doctor to ensure that proper medication management will be in place if applicable.

Who is eHealthMe?

With medical big data and proven AI/ML algorithms, eHealthMe provides a platform for everyone to run phase IV clinical trials. We study millions of patients and 5,000 more each day. Results of our real-world drug study have been referenced on 800+ peer-reviewed medical publications, including The Lancet, Mayo Clinic Proceedings, and Nature. Our analysis results are available to researchers, health care professionals, patients (testimonials), and software developers (open API).

WARNING, DISCLAIMER, USE FOR PUBLICATION

WARNING: Please DO NOT STOP MEDICATIONS without first consulting a physician since doing so could be hazardous to your health.

DISCLAIMER: All material available on eHealthMe.com is for informational purposes only, and is not a substitute for medical advice, diagnosis, or treatment provided by a qualified healthcare provider. All information is observation-only. Our phase IV clinical studies alone cannot establish cause-effect relationship. Different individuals may respond to medication in different ways. Every effort has been made to ensure that all information is accurate, up-to-date, and complete, but no guarantee is made to that effect. The use of the eHealthMe site and its content is at your own risk.

If you use this eHealthMe study on publication, please acknowledge it with a citation: study title, URL, accessed date.