Protopic and Ulcerative colitis - a phase IV clinical study of FDA data

Summary:

Ulcerative colitis is reported as a side effect among people who take Protopic (tacrolimus), especially for people who are female, 10-19 old, have been taking the drug for 1 - 6 months also take Ortho Tri-Cyclen Lo, and have Acne.

The phase IV clinical study analyzes which people have Ulcerative colitis when taking Protopic. It is created by eHealthMe based on reports of 5,328 people who have side effects when taking Protopic from the FDA, and is updated regularly.

What is Protopic?

Protopic has active ingredients of tacrolimus. It is often used in eczema. eHealthMe is studying from 5,403 Protopic users. Check the latest studies of Protopic.

What is Ulcerative colitis?

Ulcerative colitis (inflammatory bowel disease (ibd). it causes swelling, ulcerations, and loss of function of the large intestine) is found to be associated with 1,215 drugs and 2,031 conditions by eHealthMe. Check the latest studies of Ulcerative colitis.

On Dec, 13, 2025

5,328 people reported to have side effects when taking Protopic.
Among them, 20 people (0.38%) have Ulcerative colitis.

Could Protopic cause Ulcerative colitis?

Among these 20 people:

How long have people been on Protopic when they have Ulcerative colitis? *

What is the gender of people who have Ulcerative colitis when taking Protopic? *

female: 88.24 %
male: 11.76 %

What is the age of people who have Ulcerative colitis when taking Protopic? *

What are other drugs people take besides Protopic? *

Accutane: 9 people, 45.00%
Ortho Tri-Cyclen Lo: 9 people, 45.00%
Prednisone: 4 people, 20.00%
Epinephrine: 3 people, 15.00%
Liothyronine Sodium: 3 people, 15.00%
Ketotifen Fumarate: 3 people, 15.00%
Hydrocortisone: 3 people, 15.00%
Heparin: 3 people, 15.00%
Fluticasone Propionate: 3 people, 15.00%
Fish Oil: 3 people, 15.00%

What are other side effects people have besides Ulcerative colitis? *

Dizziness: 13 people, 65.00%
Inflammatory Bowel Disease: 9 people, 45.00%
Polyp: 9 people, 45.00%
Colitis (inflammation of colon): 9 people, 45.00%
Dry Skin: 9 people, 45.00%
Emotional Distress: 9 people, 45.00%
Hepatic Enzyme Increased: 9 people, 45.00%
High Blood Cholesterol: 9 people, 45.00%
Injury: 9 people, 45.00%
Irritable Bowel Syndrome: 9 people, 45.00%

What are the existing conditions these people have? *

Acne (skin problems that cause pimples): 7 people, 35.00%
Primary Immunodeficiency Syndrome: 3 people, 15.00%
Immunodeficiency Common Variable: 3 people, 15.00%
Gastric Ulcer (stomach ulcer): 3 people, 15.00%
Stress And Anxiety: 2 people, 10.00%
Juvenile Rheumatoid Arthritis (joint inflammation in children due to systemic disease): 2 people, 10.00%
Fibromyalgia (a long-term condition which causes pain all over the body): 2 people, 10.00%
Dermatitis Atopic (inflammatory, chronically relapsing, non-contagious and pruritic skin disorder): 2 people, 10.00%
Bleeding Disorders: 2 people, 10.00%
Bipolar Disorder (mood disorder): 2 people, 10.00%

* Approximation only. Some reports may have incomplete information.

Do you take Protopic and have Ulcerative colitis?

- Check whether Ulcerative colitis is associated with a drug or a condition
- Predict drug outcomes for up to one year with AI
- Get an AI agent to monitor your drugs continuously

Related studies:

Effectiveness of, long term effects of, and alternative drugs to Protopic:

Protopic (5,403 reports)

Browse all side effects of Protopic:

a b c d e f g h i j k l m n o p q r s t u v w x y z

Browse all the drugs that are associated with Ulcerative colitis:

Ulcerative colitis (1,215 drugs)

Browse all the conditions that are associated with Ulcerative colitis:

Ulcerative colitis (2,031 conditions)

How the study uses the data?

The study uses data from the FDA. It is based on tacrolimus (the active ingredients of Protopic) and Protopic (the brand name). Other drugs that have the same active ingredients (e.g. generic drugs) are not considered. Dosage of drugs is not considered in the study.

How to use the study?

DO NOT STOP MEDICATIONS without first consulting your doctor. If there are any serious or long term adverse effects discovered in the study, discuss the study with your doctor to ensure that proper medication management will be in place if applicable.

Who is eHealthMe?

With medical big data and proven AI/ML algorithms, eHealthMe provides a platform for everyone to run phase IV clinical trials. We study millions of patients and 5,000 more each day. Results of our real-world drug study have been referenced on 800+ peer-reviewed medical publications, including The Lancet, Mayo Clinic Proceedings, and Nature. Our analysis results are available to researchers, health care professionals, patients (testimonials), and software developers (open API).

WARNING, DISCLAIMER, USE FOR PUBLICATION

WARNING: Please DO NOT STOP MEDICATIONS without first consulting a physician since doing so could be hazardous to your health.

DISCLAIMER: All material available on eHealthMe.com is for informational purposes only, and is not a substitute for medical advice, diagnosis, or treatment provided by a qualified healthcare provider. All information is observation-only. Our phase IV clinical studies alone cannot establish cause-effect relationship. Different individuals may respond to medication in different ways. Every effort has been made to ensure that all information is accurate, up-to-date, and complete, but no guarantee is made to that effect. The use of the eHealthMe site and its content is at your own risk.

If you use this eHealthMe study on publication, please acknowledge it with a citation: study title, URL, accessed date.