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Rapaflo and Osteoporosis - a phase IV clinical study of FDA data

Summary:

Osteoporosis is reported as a side effect among people who take Rapaflo (silodosin), especially for people who are male, 50-59 old, have been taking the drug for 2 - 5 years also take Ondansetron, and have Hiv infection.

The phase IV clinical study analyzes which people have Osteoporosis when taking Rapaflo. It is created by eHealthMe based on reports of 3,636 people who have side effects when taking Rapaflo from the FDA, and is updated regularly.

What is Rapaflo?

Rapaflo has active ingredients of silodosin. It is often used in prostate examination abnormal. eHealthMe is studying from 3,929 Rapaflo users. Check the latest studies of Rapaflo.

What is Osteoporosis?

Osteoporosis (bones weak and more likely to break) is found to be associated with 1,811 drugs and 1,902 conditions by eHealthMe. Check the latest studies of Osteoporosis.

On Jul, 20, 2026

3,636 people reported to have side effects when taking Rapaflo.
Among them, 16 people (0.44%) have Osteoporosis.

Could Rapaflo cause Osteoporosis?

Among these 16 people:

How long have people been on Rapaflo when they have Osteoporosis? *

  • < 1 month: 0.0 %
  • 1 - 6 months: 37.5 %
  • 6 - 12 months: 0.0 %
  • 1 - 2 years: 0.0 %
  • 2 - 5 years: 62.5 %
  • 5 - 10 years: 0.0 %
  • 10+ years: 0.0 %

What is the gender of people who have Osteoporosis when taking Rapaflo? *

  • female: 37.5 %
  • male: 62.5 %

What is the age of people who have Osteoporosis when taking Rapaflo? *

  • 0-1: 0.0 %
  • 2-9: 0.0 %
  • 10-19: 0.0 %
  • 20-29: 0.0 %
  • 30-39: 0.0 %
  • 40-49: 40 %
  • 50-59: 60 %
  • 60+: 0.0 %

What are other drugs people take besides Rapaflo? *

  1. Ondansetron: 10 people, 62.50%
  2. Zoloft: 7 people, 43.75%
  3. Tamsulosin: 7 people, 43.75%
  4. Pyridium: 5 people, 31.25%
  5. Maxalt: 5 people, 31.25%
  6. Ritalin: 5 people, 31.25%
  7. Restasis: 5 people, 31.25%
  8. Reclast: 5 people, 31.25%
  9. Flonase Allergy Relief: 5 people, 31.25%
  10. Flaxseed: 5 people, 31.25%

What are other side effects people have besides Osteoporosis? *

  1. Pain: 8 people, 50.00%
  2. Emotional Distress: 7 people, 43.75%
  3. Stress And Anxiety: 7 people, 43.75%
  4. Anhedonia (inability to experience pleasure from activities usually found enjoyable): 7 people, 43.75%
  5. Fall: 6 people, 37.50%
  6. Loss Of Consciousness: 6 people, 37.50%
  7. Diarrhea: 6 people, 37.50%
  8. Bone Density Decreased: 6 people, 37.50%
  9. Fluid Imbalance (imbalance of fluid in body in intake and fluid lost): 5 people, 31.25%
  10. Pneumonia Aspiration (bronchopneumonia that develops due to the entrance of foreign materials into the bronchial tree): 5 people, 31.25%

What are the existing conditions these people have? *

  1. Hiv Infection: 7 people, 43.75%
  2. Cataplexy (loss of muscle tone accompanied by full conscious awareness): 5 people, 31.25%
  3. Fluid Imbalance (imbalance of fluid in body in intake and fluid lost): 5 people, 31.25%
  4. Narcolepsy (brain's inability to regulate sleep-wake cycles normally): 5 people, 31.25%
  5. High Blood Cholesterol: 5 people, 31.25%
  6. High Blood Pressure: 3 people, 18.75%
  7. Diabetes: 3 people, 18.75%
  8. Diarrhea: 3 people, 18.75%
  9. Faeces Hard: 3 people, 18.75%
  10. Bacterial Infection: 3 people, 18.75%

* Approximation only. Some reports may have incomplete information.

Do you take Rapaflo and have Osteoporosis?

- Check whether Osteoporosis is associated with a drug or a condition
- Predict drug outcomes for up to one year with AI
- Get an AI agent to monitor your drugs continuously

Related studies:

Effectiveness of, long term effects of, and alternative drugs to Rapaflo:

Osteoporosis treatments and more:

How severe was Osteoporosis and when was it recovered:

Expand to all the drugs that have ingredients of silodosin:

Sub-studies by gender and age:

Female: 0-1 2-9 10-19 20-29 30-39 40-49 50-59 60+

Male: 0-1 2-9 10-19 20-29 30-39 40-49 50-59 60+

Browse all side effects of Rapaflo:

a b c d e f g h i j k l m n o p q r s t u v w x y z

Browse all the drugs that are associated with Osteoporosis:

Browse all the conditions that are associated with Osteoporosis:

Related publications that referenced our studies

How the study uses the data?

The study uses data from the FDA. It is based on silodosin (the active ingredients of Rapaflo) and Rapaflo (the brand name). Other drugs that have the same active ingredients (e.g. generic drugs) are not considered. Dosage of drugs is not considered in the study.

How to use the study?

DO NOT STOP MEDICATIONS without first consulting your doctor. If there are any serious or long term adverse effects discovered in the study, discuss the study with your doctor to ensure that proper medication management will be in place if applicable.

Who is eHealthMe?

With medical big data and proven AI/ML algorithms, eHealthMe provides a platform for everyone to run phase IV clinical trials. We study millions of patients and 5,000 more each day. Results of our real-world drug study have been referenced on 800+ peer-reviewed medical publications, including The Lancet, Mayo Clinic Proceedings, and Nature. Our analysis results are available to researchers, health care professionals, patients (testimonials), and software developers (open API).

WARNING, DISCLAIMER, USE FOR PUBLICATION

WARNING: Please DO NOT STOP MEDICATIONS without first consulting a physician since doing so could be hazardous to your health.

DISCLAIMER: All material available on eHealthMe.com is for informational purposes only, and is not a substitute for medical advice, diagnosis, or treatment provided by a qualified healthcare provider. All information is observation-only. Our phase IV clinical studies alone cannot establish cause-effect relationship. Different individuals may respond to medication in different ways. Every effort has been made to ensure that all information is accurate, up-to-date, and complete, but no guarantee is made to that effect. The use of the eHealthMe site and its content is at your own risk.

If you use this eHealthMe study on publication, please acknowledge it with a citation: study title, URL, accessed date.

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