Simvastatin and Gallbladder operation - a phase IV clinical study of FDA data

Summary:

Gallbladder operation is reported as a side effect among people who take Simvastatin (simvastatin), especially for people who are female, 60+ old, have been taking the drug for 2 - 5 years also take Forteo, and have Osteoporosis.

The phase IV clinical study analyzes which people have Gallbladder operation when taking Simvastatin. It is created by eHealthMe based on reports of 249,370 people who have side effects when taking Simvastatin from the FDA, and is updated regularly.

What is Simvastatin?

Simvastatin has active ingredients of simvastatin. It is often used in high blood cholesterol. eHealthMe is studying from 256,967 Simvastatin users. Check the latest studies of Simvastatin.

What is Gallbladder operation?

Gallbladder operation is found to be associated with 352 drugs and 773 conditions by eHealthMe. Check the latest studies of Gallbladder operation.

On Feb, 03, 2026

249,370 people reported to have side effects when taking Simvastatin.
Among them, 44 people (0.02%) have Gallbladder operation.

Could Simvastatin cause Gallbladder operation?

Among these 44 people:

How long have people been on Simvastatin when they have Gallbladder operation? *

What is the gender of people who have Gallbladder operation when taking Simvastatin? *

female: 82.93 %
male: 17.07 %

What is the age of people who have Gallbladder operation when taking Simvastatin? *

What are other drugs people take besides Simvastatin? *

What are other side effects people have besides Gallbladder operation? *

Abdominal Pain Upper: 6 people, 13.64%
Joint Pain: 6 people, 13.64%
Head Injury: 5 people, 11.36%
Gallstones (stone formation by bile component): 4 people, 9.09%
Gastroesophageal Reflux Disease (a condition in which stomach contents leak backward from the stomach into the oesophagus): 4 people, 9.09%
Muscle Aches (muscle pain): 4 people, 9.09%
Pancreatitis (inflammation of pancreas): 4 people, 9.09%
Injection Site Haematoma (localized swelling filled with blood at injection site): 3 people, 6.82%
Rashes (redness): 3 people, 6.82%
Depression: 3 people, 6.82%

What are the existing conditions these people have? *

Osteoporosis (bones weak and more likely to break): 10 people, 22.73%
Rheumatoid Arthritis (a chronic progressive disease causing inflammation in the joints): 8 people, 18.18%
Multiple Sclerosis (a nervous system disease that affects your brain and spinal cord. it damages the myelin sheath): 6 people, 13.64%
Gastroesophageal Reflux Disease (a condition in which stomach contents leak backward from the stomach into the oesophagus): 4 people, 9.09%
Hypothyroidism (abnormally low activity of the thyroid gland, resulting in retardation of growth and mental development): 3 people, 6.82%
Psoriatic Arthropathy (inflammation of the skin and joints with kin condition which typically causes patches (plaques) of red, scaly skin to develop): 3 people, 6.82%
Psoriasis (immune-mediated disease that affects the skin): 2 people, 4.55%
Diabetes: 2 people, 4.55%
Insomnia (sleeplessness): 2 people, 4.55%
Crohn's Disease (a condition that causes inflammation of the gastrointestinal tract): 2 people, 4.55%

* Approximation only. Some reports may have incomplete information.

Do you take Simvastatin and have Gallbladder operation?

- Check whether Gallbladder operation is associated with a drug or a condition
- Predict drug outcomes for up to one year with AI
- Get an AI agent to monitor your drugs continuously

Related studies:

Effectiveness of, long term effects of, and alternative drugs to Simvastatin:

Simvastatin (256,967 reports)

Browse all side effects of Simvastatin:

a b c d e f g h i j k l m n o p q r s t u v w x y z

Browse all the drugs that are associated with Gallbladder operation:

Gallbladder operation (352 drugs)

Browse all the conditions that are associated with Gallbladder operation:

Gallbladder operation (773 conditions)

How the study uses the data?

The study uses data from the FDA. It is based on simvastatin (the active ingredients of Simvastatin) and Simvastatin (the brand name). Other drugs that have the same active ingredients (e.g. generic drugs) are not considered. Dosage of drugs is not considered in the study.

How to use the study?

DO NOT STOP MEDICATIONS without first consulting your doctor. If there are any serious or long term adverse effects discovered in the study, discuss the study with your doctor to ensure that proper medication management will be in place if applicable.

Who is eHealthMe?

With medical big data and proven AI/ML algorithms, eHealthMe provides a platform for everyone to run phase IV clinical trials. We study millions of patients and 5,000 more each day. Results of our real-world drug study have been referenced on 800+ peer-reviewed medical publications, including The Lancet, Mayo Clinic Proceedings, and Nature. Our analysis results are available to researchers, health care professionals, patients (testimonials), and software developers (open API).

WARNING, DISCLAIMER, USE FOR PUBLICATION

WARNING: Please DO NOT STOP MEDICATIONS without first consulting a physician since doing so could be hazardous to your health.

DISCLAIMER: All material available on eHealthMe.com is for informational purposes only, and is not a substitute for medical advice, diagnosis, or treatment provided by a qualified healthcare provider. All information is observation-only. Our phase IV clinical studies alone cannot establish cause-effect relationship. Different individuals may respond to medication in different ways. Every effort has been made to ensure that all information is accurate, up-to-date, and complete, but no guarantee is made to that effect. The use of the eHealthMe site and its content is at your own risk.

If you use this eHealthMe study on publication, please acknowledge it with a citation: study title, URL, accessed date.