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Simvastatin and Hypertensive encephalopathy - a phase IV clinical study of FDA data

Summary:

Hypertensive encephalopathy is reported as a side effect among people who take Simvastatin (simvastatin), especially for people who are female, 60+ old, also take Detrol La, and have Diabetes.

The phase IV clinical study analyzes which people have Hypertensive encephalopathy when taking Simvastatin. It is created by eHealthMe based on reports of 249,370 people who have side effects when taking Simvastatin from the FDA, and is updated regularly.

What is Simvastatin?

Simvastatin has active ingredients of simvastatin. It is often used in high blood cholesterol. eHealthMe is studying from 256,970 Simvastatin users. Check the latest studies of Simvastatin.

What is Hypertensive encephalopathy?

Hypertensive encephalopathy (neurological dysfunction induced by malignant hypertension) is found to be associated with 131 drugs and 266 conditions by eHealthMe. Check the latest studies of Hypertensive encephalopathy.

eHealthMe: drug outcomes in the real world

eHealthMe runs one of the largest post-marketing drug safety studies in the world. We study millions of patients and 5,000 more each day. Our data-driven phase IV clinical trials have been referenced on 800+ peer-reviewed medical publications including The Lancet, Mayo Clinic Proceedings, and Nature. Tools to study our phase IV findings are available to the public, anonymous and free >>>.

On Aug, 16, 2026

249,370 people reported to have side effects when taking Simvastatin.
Among them, 11 people (0.0%) have Hypertensive encephalopathy.

Could Simvastatin cause Hypertensive encephalopathy?

Among these 11 people:

What is the gender of people who have Hypertensive encephalopathy when taking Simvastatin? *

  • female: 77.78 %
  • male: 22.22 %

What is the age of people who have Hypertensive encephalopathy when taking Simvastatin? *

  • 0-1: 0.0 %
  • 2-9: 0.0 %
  • 10-19: 0.0 %
  • 20-29: 0.0 %
  • 30-39: 0.0 %
  • 40-49: 14.29 %
  • 50-59: 0.0 %
  • 60+: 85.71 %

What are other drugs people take besides Simvastatin? *

  1. Mestinon: 2 people, 18.18%
  2. Nitrofurantoin: 2 people, 18.18%
  3. Amlodipine: 2 people, 18.18%
  4. Asa: 2 people, 18.18%
  5. Avonex: 2 people, 18.18%
  6. Baclofen: 2 people, 18.18%
  7. Centrum Silver: 2 people, 18.18%
  8. Depakote: 2 people, 18.18%
  9. Depakote Er: 2 people, 18.18%
  10. Detrol La: 2 people, 18.18%

What are other side effects people have besides Hypertensive encephalopathy? *

  1. Headache (pain in head): 3 people, 27.27%
  2. Tremor (trembling or shaking movements in one or more parts of your body): 3 people, 27.27%
  3. Speech Disorder: 3 people, 27.27%
  4. Gait Disturbance: 2 people, 18.18%
  5. Balance Disorder: 2 people, 18.18%
  6. Coordination Abnormal (abnormal movement): 2 people, 18.18%
  7. Convulsion (muscles contract and relax rapidly and repeatedly, resulting in an uncontrolled shaking of the body): 2 people, 18.18%
  8. Memory Loss: 2 people, 18.18%
  9. Movement Disorder (neurological syndromes where they may be excess of movement or a paucity of movement that is not connected to weakness): 2 people, 18.18%
  10. Impaired Driving Ability: 2 people, 18.18%

What are the existing conditions these people have? *

  1. Seizures (abnormal excessive or synchronous neuronal activity in the brain): 2 people, 18.18%
  2. Myasthenia Gravis (a chronic condition that causes muscles to tire and weaken easily): 2 people, 18.18%
  3. Muscle Spasticity (tight or stiff muscles and an inability to control those muscles): 2 people, 18.18%
  4. Multiple Sclerosis (a nervous system disease that affects your brain and spinal cord. it damages the myelin sheath): 2 people, 18.18%
  5. Joint Pain: 2 people, 18.18%
  6. Haemolytic Uraemic Syndrome (blood clotting disease caused by e. coli infection, birth control pills, pneumonia, medications, and more): 2 people, 18.18%
  7. Gastroesophageal Reflux Disease (a condition in which stomach contents leak backward from the stomach into the oesophagus): 2 people, 18.18%
  8. Epilepsy (common and diverse set of chronic neurological disorders characterized by seizures): 2 people, 18.18%
  9. Dyslipidaemia (abnormal amount of lipids): 2 people, 18.18%
  10. Diabetes: 2 people, 18.18%

* Approximation only. Some reports may have incomplete information.

Do you take Simvastatin and have Hypertensive encephalopathy?

- Check whether Hypertensive encephalopathy is associated with a drug or a condition
- Predict drug outcomes for up to one year with AI
- Get an AI agent to monitor your drugs continuously

Related studies:

Effectiveness of, long term effects of, and alternative drugs to Simvastatin:

Hypertensive encephalopathy treatments and more:

How severe was Hypertensive encephalopathy and when was it recovered:

Expand to all the drugs that have ingredients of simvastatin:

Sub-studies by gender and age:

Female: 0-1 2-9 10-19 20-29 30-39 40-49 50-59 60+

Male: 0-1 2-9 10-19 20-29 30-39 40-49 50-59 60+

Browse all side effects of Simvastatin:

a b c d e f g h i j k l m n o p q r s t u v w x y z

Browse all the drugs that are associated with Hypertensive encephalopathy:

Browse all the conditions that are associated with Hypertensive encephalopathy:

Related publications that referenced our studies

How the study uses the data?

The study uses data from the FDA. It is based on simvastatin (the active ingredients of Simvastatin) and Simvastatin (the brand name). Other drugs that have the same active ingredients (e.g. generic drugs) are not considered. Dosage of drugs is not considered in the study.

How to use the study?

DO NOT STOP MEDICATIONS without first consulting your doctor. If there are any serious or long term adverse effects discovered in the study, discuss the study with your doctor to ensure that proper medication management will be in place if applicable.

Who is eHealthMe?

With medical big data and proven AI/ML algorithms, eHealthMe provides a platform for everyone to run phase IV clinical trials. We study millions of patients and 5,000 more each day. Results of our real-world drug study have been referenced on 800+ peer-reviewed medical publications, including The Lancet, Mayo Clinic Proceedings, and Nature. Our analysis results are available to researchers, health care professionals, patients (testimonials), and software developers (open API).

WARNING, DISCLAIMER, USE FOR PUBLICATION

WARNING: Please DO NOT STOP MEDICATIONS without first consulting a physician since doing so could be hazardous to your health.

DISCLAIMER: All material available on eHealthMe.com is for informational purposes only, and is not a substitute for medical advice, diagnosis, or treatment provided by a qualified healthcare provider. All information is observation-only. Our phase IV clinical studies alone cannot establish cause-effect relationship. Different individuals may respond to medication in different ways. Every effort has been made to ensure that all information is accurate, up-to-date, and complete, but no guarantee is made to that effect. The use of the eHealthMe site and its content is at your own risk.

If you use this eHealthMe study on publication, please acknowledge it with a citation: study title, URL, accessed date.

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