Simvastatin and Onychomadesis - a phase IV clinical study of FDA data

Summary:

Onychomadesis is reported as a side effect among people who take Simvastatin (simvastatin), especially for people who are female, 60+ old, have been taking the drug for 1 - 2 years also take Metformin, and have Pain.

The phase IV clinical study analyzes which people have Onychomadesis when taking Simvastatin. It is created by eHealthMe based on reports of 249,370 people who have side effects when taking Simvastatin from the FDA, and is updated regularly.

What is Simvastatin?

Simvastatin has active ingredients of simvastatin. It is often used in high blood cholesterol. eHealthMe is studying from 256,970 Simvastatin users. Check the latest studies of Simvastatin.

What is Onychomadesis?

Onychomadesis (a periodic idiopathic shedding of the nails) is found to be associated with 421 drugs and 521 conditions by eHealthMe. Check the latest studies of Onychomadesis.

eHealthMe: drug outcomes in the real world

eHealthMe runs one of the largest post-marketing drug safety studies in the world. We study millions of patients and 5,000 more each day. Our data-driven phase IV clinical trials have been referenced on 800+ peer-reviewed medical publications including The Lancet, Mayo Clinic Proceedings, and Nature. Tools to study our phase IV findings are available to the public, anonymous and free >>>.

On Aug, 31, 2026

249,370 people reported to have side effects when taking Simvastatin.
Among them, 43 people (0.02%) have Onychomadesis.

Among these 43 people:

How long have people been on Simvastatin when they have Onychomadesis? *

What is the gender of people who have Onychomadesis when taking Simvastatin? *

female: 56.1 %
male: 43.9 %

What is the age of people who have Onychomadesis when taking Simvastatin? *

What are other drugs people take besides Simvastatin? *

What are other side effects people have besides Onychomadesis? *

Appetite - Decreased (decreased appetite occurs when you have a reduced desire to eat): 10 people, 23.26%
Pain In Extremity: 9 people, 20.93%
Fatigue (feeling of tiredness): 8 people, 18.60%
Diarrhea: 8 people, 18.60%
Blister (small pocket of fluid within the upper layers of the skin caused by forceful rubbing (friction), burning, freezing, chemical exposure): 8 people, 18.60%
Weight Decreased: 8 people, 18.60%
Rashes (redness): 7 people, 16.28%
Onychoclasis (breaking of the nails): 7 people, 16.28%
Weakness: 7 people, 16.28%
Hair Loss: 7 people, 16.28%

What are the existing conditions these people have? *

Pain: 7 people, 16.28%
Cardiac Disorder: 5 people, 11.63%
Primary Pulmonary Hypertension (primary high blood pressure that affects the arteries in the lungs and the right side of your heart): 5 people, 11.63%
Psoriatic Arthropathy (inflammation of the skin and joints with kin condition which typically causes patches (plaques) of red, scaly skin to develop): 4 people, 9.30%
Atrial Fibrillation/flutter (atrial fibrillation and flutter are abnormal heart rhythms in which the atria, or upper chambers of the heart, are out of sync with the ventricles): 4 people, 9.30%
Psoriasis (immune-mediated disease that affects the skin): 4 people, 9.30%
Osteoarthritis (a joint disease caused by cartilage loss in a joint): 3 people, 6.98%
Indigestion: 2 people, 4.65%
Fluid Imbalance (imbalance of fluid in body in intake and fluid lost): 2 people, 4.65%
Hypothyroidism (abnormally low activity of the thyroid gland, resulting in retardation of growth and mental development): 2 people, 4.65%

* Approximation only. Some reports may have incomplete information.

Do you take Simvastatin and have Onychomadesis?

- Check whether Onychomadesis is associated with a drug or a condition
- Predict drug outcomes for up to one year with AI
- Get an AI agent to monitor your drugs continuously

Related studies:

Effectiveness of, long term effects of, and alternative drugs to Simvastatin:

Simvastatin (256,970 reports)

Onychomadesis treatments and more:

Onychomadesis (3,910 reports)

Browse all side effects of Simvastatin:

a b c d e f g h i j k l m n o p q r s t u v w x y z

Browse all the drugs that are associated with Onychomadesis:

Onychomadesis (421 drugs)

Browse all the conditions that are associated with Onychomadesis:

Onychomadesis (521 conditions)

How the study uses the data?

The study uses data from the FDA. It is based on simvastatin (the active ingredients of Simvastatin) and Simvastatin (the brand name). Other drugs that have the same active ingredients (e.g. generic drugs) are not considered. Dosage of drugs is not considered in the study.

How to use the study?

DO NOT STOP MEDICATIONS without first consulting your doctor. If there are any serious or long term adverse effects discovered in the study, discuss the study with your doctor to ensure that proper medication management will be in place if applicable.

Who is eHealthMe?

With medical big data and proven AI/ML algorithms, eHealthMe provides a platform for everyone to run phase IV clinical trials. We study millions of patients and 5,000 more each day. Results of our real-world drug study have been referenced on 800+ peer-reviewed medical publications, including The Lancet, Mayo Clinic Proceedings, and Nature. Our analysis results are available to researchers, health care professionals, patients (testimonials), and software developers (open API).

WARNING, DISCLAIMER, USE FOR PUBLICATION

WARNING: Please DO NOT STOP MEDICATIONS without first consulting a physician since doing so could be hazardous to your health.

DISCLAIMER: All material available on eHealthMe.com is for informational purposes only, and is not a substitute for medical advice, diagnosis, or treatment provided by a qualified healthcare provider. All information is observation-only. Our phase IV clinical studies alone cannot establish cause-effect relationship. Different individuals may respond to medication in different ways. Every effort has been made to ensure that all information is accurate, up-to-date, and complete, but no guarantee is made to that effect. The use of the eHealthMe site and its content is at your own risk.

If you use this eHealthMe study on publication, please acknowledge it with a citation: study title, URL, accessed date.