Simvastatin and Sciatic nerve dysfunction - a phase IV clinical study of FDA data

Summary:

Sciatic nerve dysfunction is reported as a side effect among people who take Simvastatin (simvastatin), especially for people who are female, 60+ old, have been taking the drug for 1 - 6 months also take Aspirin, and have Rheumatoid arthritis.

The phase IV clinical study analyzes which people have Sciatic nerve dysfunction when taking Simvastatin. It is created by eHealthMe based on reports of 249,370 people who have side effects when taking Simvastatin from the FDA, and is updated regularly.

What is Simvastatin?

Simvastatin has active ingredients of simvastatin. It is often used in high blood cholesterol. eHealthMe is studying from 256,961 Simvastatin users. Check the latest studies of Simvastatin.

What is Sciatic nerve dysfunction?

Sciatic nerve dysfunction (a condition in which the sciatic nerve conducts impulses abnormally) is found to be associated with 1,939 drugs and 1,448 conditions by eHealthMe. Check the latest studies of Sciatic nerve dysfunction.

On Nov, 20, 2025

249,370 people reported to have side effects when taking Simvastatin.
Among them, 407 people (0.16%) have Sciatic nerve dysfunction.

Could Simvastatin cause Sciatic nerve dysfunction?

Among these 407 people:

How long have people been on Simvastatin when they have Sciatic nerve dysfunction? *

What is the gender of people who have Sciatic nerve dysfunction when taking Simvastatin? *

female: 66.16 %
male: 33.84 %

What is the age of people who have Sciatic nerve dysfunction when taking Simvastatin? *

What are other drugs people take besides Simvastatin? *

What are other side effects people have besides Sciatic nerve dysfunction? *

Pain: 97 people, 23.83%
Back Pain: 97 people, 23.83%
Pain In Extremity: 96 people, 23.59%
Joint Pain: 93 people, 22.85%
Fatigue (feeling of tiredness): 85 people, 20.88%
Muscle Spasms (muscle contraction): 66 people, 16.22%
Fall: 64 people, 15.72%
Stress And Anxiety: 62 people, 15.23%
Insomnia (sleeplessness): 61 people, 14.99%
Weakness: 61 people, 14.99%

What are the existing conditions these people have? *

Rheumatoid Arthritis (a chronic progressive disease causing inflammation in the joints): 79 people, 19.41%
Pain: 45 people, 11.06%
Constipation: 23 people, 5.65%
Psoriatic Arthropathy (inflammation of the skin and joints with kin condition which typically causes patches (plaques) of red, scaly skin to develop): 21 people, 5.16%
Depression: 19 people, 4.67%
Atrial Fibrillation/flutter (atrial fibrillation and flutter are abnormal heart rhythms in which the atria, or upper chambers of the heart, are out of sync with the ventricles): 19 people, 4.67%
Osteoporosis (bones weak and more likely to break): 16 people, 3.93%
Gastroesophageal Reflux Disease (a condition in which stomach contents leak backward from the stomach into the oesophagus): 16 people, 3.93%
Hepatocellular Carcinoma (liver cancer): 15 people, 3.69%
Stress And Anxiety: 15 people, 3.69%

* Approximation only. Some reports may have incomplete information.

Do you take Simvastatin and have Sciatic nerve dysfunction?

- Check whether Sciatic nerve dysfunction is associated with a drug or a condition
- Predict drug outcomes for up to one year with AI
- Get an AI agent to monitor your drugs continuously

Related studies:

Effectiveness of, long term effects of, and alternative drugs to Simvastatin:

Simvastatin (256,961 reports)

Browse all side effects of Simvastatin:

a b c d e f g h i j k l m n o p q r s t u v w x y z

Common drugs associated with Sciatic nerve dysfunction:

Browse all the drugs that are associated with Sciatic nerve dysfunction:

Sciatic nerve dysfunction (1,939 drugs)

Common conditions associated with Sciatic nerve dysfunction:

Ra: 3,984 reports
Osteoporosis: 1,578 reports
Psoriatic arthropathy aggravated: 1,283 reports
Pain: 1,076 reports
Pain relief: 1,069 reports
Ms: 1,038 reports
Hypertension: 930 reports
Blood pressure - high: 922 reports
Blood triglycerides abnormal: 804 reports
Psoriasis: 785 reports

Browse all the conditions that are associated with Sciatic nerve dysfunction:

Sciatic nerve dysfunction (1,448 conditions)

Drugs similar to Simvastatin and Sciatic nerve dysfunction :

How the study uses the data?

The study uses data from the FDA. It is based on simvastatin (the active ingredients of Simvastatin) and Simvastatin (the brand name). Other drugs that have the same active ingredients (e.g. generic drugs) are not considered. Dosage of drugs is not considered in the study.

How to use the study?

DO NOT STOP MEDICATIONS without first consulting your doctor. If there are any serious or long term adverse effects discovered in the study, discuss the study with your doctor to ensure that proper medication management will be in place if applicable.

Who is eHealthMe?

With medical big data and proven AI/ML algorithms, eHealthMe provides a platform for everyone to run phase IV clinical trials. We study millions of patients and 5,000 more each day. Results of our real-world drug study have been referenced on 800+ peer-reviewed medical publications, including The Lancet, Mayo Clinic Proceedings, and Nature. Our analysis results are available to researchers, health care professionals, patients (testimonials), and software developers (open API).

WARNING, DISCLAIMER, USE FOR PUBLICATION

WARNING: Please DO NOT STOP MEDICATIONS without first consulting a physician since doing so could be hazardous to your health.

DISCLAIMER: All material available on eHealthMe.com is for informational purposes only, and is not a substitute for medical advice, diagnosis, or treatment provided by a qualified healthcare provider. All information is observation-only. Our phase IV clinical studies alone cannot establish cause-effect relationship. Different individuals may respond to medication in different ways. Every effort has been made to ensure that all information is accurate, up-to-date, and complete, but no guarantee is made to that effect. The use of the eHealthMe site and its content is at your own risk.

If you use this eHealthMe study on publication, please acknowledge it with a citation: study title, URL, accessed date.