Vytorin and Sciatic nerve dysfunction - a phase IV clinical study of FDA data

Summary:

Sciatic nerve dysfunction is reported as a side effect among people who take Vytorin (ezetimibe; simvastatin), especially for people who are female, 60+ old, have been taking the drug for < 1 month also take Aspirin, and have Osteoporosis.

The phase IV clinical study analyzes which people have Sciatic nerve dysfunction when taking Vytorin. It is created by eHealthMe based on reports of 19,379 people who have side effects when taking Vytorin from the FDA, and is updated regularly.

What is Vytorin?

Vytorin has active ingredients of ezetimibe; simvastatin. It is often used in high blood cholesterol. eHealthMe is studying from 20,084 Vytorin users. Check the latest studies of Vytorin.

What is Sciatic nerve dysfunction?

Sciatic nerve dysfunction (a condition in which the sciatic nerve conducts impulses abnormally) is found to be associated with 1,942 drugs and 1,447 conditions by eHealthMe. Check the latest studies of Sciatic nerve dysfunction.

On Oct, 13, 2025

19,379 people reported to have side effects when taking Vytorin.
Among them, 47 people (0.24%) have Sciatic nerve dysfunction.

Could Vytorin cause Sciatic nerve dysfunction?

Among these 47 people:

How long have people been on Vytorin when they have Sciatic nerve dysfunction? *

What is the gender of people who have Sciatic nerve dysfunction when taking Vytorin? *

female: 65.96 %
male: 34.04 %

What is the age of people who have Sciatic nerve dysfunction when taking Vytorin? *

What are other drugs people take besides Vytorin? *

What are other side effects people have besides Sciatic nerve dysfunction? *

Back Pain: 22 people, 46.81%
Pain: 21 people, 44.68%
Fall: 19 people, 40.43%
Pain In Extremity: 15 people, 31.91%
Gait Disturbance: 14 people, 29.79%
Intervertebral Disc Protrusion (spinal disc protrusion): 13 people, 27.66%
Muscle Spasms (muscle contraction): 13 people, 27.66%
Joint Pain: 13 people, 27.66%
Musculoskeletal Pain (pain affects the bones, muscles, ligaments, tendons, and nerves): 12 people, 25.53%
Spinal Osteoarthritis (joint cartilage loss in spine): 12 people, 25.53%

What are the existing conditions these people have? *

Osteoporosis (bones weak and more likely to break): 13 people, 27.66%
Gastroesophageal Reflux Disease (a condition in which stomach contents leak backward from the stomach into the oesophagus): 5 people, 10.64%
Type 2 Diabetes: 4 people, 8.51%
Bone Disorder: 4 people, 8.51%
Neuropathy Peripheral (surface nerve damage): 3 people, 6.38%
Osteopenia (a condition where bone mineral density is lower than normal): 3 people, 6.38%
Cardiac Disorder: 2 people, 4.26%
Joint Pain: 2 people, 4.26%
Metastases To Bone (cancer spreads to bone): 2 people, 4.26%
Diabetes: 2 people, 4.26%

* Approximation only. Some reports may have incomplete information.

Do you take Vytorin and have Sciatic nerve dysfunction?

- Check whether Sciatic nerve dysfunction is associated with a drug or a condition
- Predict drug outcomes for up to one year with AI
- Get an AI agent to monitor your drugs continuously

Related studies:

Effectiveness of, long term effects of, and alternative drugs to Vytorin:

Vytorin (20,084 reports)

Browse all side effects of Vytorin:

a b c d e f g h i j k l m n o p q r s t u v w x y z

Browse all the drugs that are associated with Sciatic nerve dysfunction:

Sciatic nerve dysfunction (1,942 drugs)

Browse all the conditions that are associated with Sciatic nerve dysfunction:

Sciatic nerve dysfunction (1,447 conditions)

Drugs similar to Vytorin and Sciatic nerve dysfunction :

How the study uses the data?

The study uses data from the FDA. It is based on ezetimibe; simvastatin (the active ingredients of Vytorin) and Vytorin (the brand name). Other drugs that have the same active ingredients (e.g. generic drugs) are not considered. Dosage of drugs is not considered in the study.

How to use the study?

DO NOT STOP MEDICATIONS without first consulting your doctor. If there are any serious or long term adverse effects discovered in the study, discuss the study with your doctor to ensure that proper medication management will be in place if applicable.

Who is eHealthMe?

With medical big data and proven AI/ML algorithms, eHealthMe provides a platform for everyone to run phase IV clinical trials. We study millions of patients and 5,000 more each day. Results of our real-world drug study have been referenced on 800+ peer-reviewed medical publications, including The Lancet, Mayo Clinic Proceedings, and Nature. Our analysis results are available to researchers, health care professionals, patients (testimonials), and software developers (open API).

WARNING, DISCLAIMER, USE FOR PUBLICATION

WARNING: Please DO NOT STOP MEDICATIONS without first consulting a physician since doing so could be hazardous to your health.

DISCLAIMER: All material available on eHealthMe.com is for informational purposes only, and is not a substitute for medical advice, diagnosis, or treatment provided by a qualified healthcare provider. All information is observation-only. Our phase IV clinical studies alone cannot establish cause-effect relationship. Different individuals may respond to medication in different ways. Every effort has been made to ensure that all information is accurate, up-to-date, and complete, but no guarantee is made to that effect. The use of the eHealthMe site and its content is at your own risk.

If you use this eHealthMe study on publication, please acknowledge it with a citation: study title, URL, accessed date.