Tylenol w/ codeine and Sinus node dysfunction - a phase IV clinical study of FDA data

Summary:

Sinus node dysfunction is reported as a side effect among people who take Tylenol w/ codeine (acetaminophen; codeine phosphate), especially for people who are male, 60+ old, also take Vioxx, and have Arthritis.

The phase IV clinical study analyzes which people have Sinus node dysfunction when taking Tylenol w/ codeine. It is created by eHealthMe based on reports of 7,307 people who have side effects when taking Tylenol w/ codeine from the FDA, and is updated regularly.

What is Tylenol w/ codeine?

Tylenol w/ codeine has active ingredients of acetaminophen; codeine phosphate. It is often used in pain. eHealthMe is studying from 8,105 Tylenol w/ codeine users. Check the latest studies of Tylenol w/ codeine.

What is Sinus node dysfunction?

Sinus node dysfunction (a group of abnormal heart rhythms) is found to be associated with 1,266 drugs and 834 conditions by eHealthMe. Check the latest studies of Sinus node dysfunction.

On Oct, 17, 2025

7,307 people reported to have side effects when taking Tylenol w/ codeine.
Among them, 13 people (0.18%) have Sinus node dysfunction.

Could Tylenol w/ codeine cause Sinus node dysfunction?

Among these 13 people:

What is the gender of people who have Sinus node dysfunction when taking Tylenol w/ codeine? *

female: 46.15 %
male: 53.85 %

What is the age of people who have Sinus node dysfunction when taking Tylenol w/ codeine? *

What are other drugs people take besides Tylenol w/ codeine? *

What are other side effects people have besides Sinus node dysfunction? *

Heart Attack: 12 people, 92.31%
Abdominal Pain: 10 people, 76.92%
Atelectasis (partial or complete collapse of the lung): 8 people, 61.54%
Atrial Fibrillation/flutter (atrial fibrillation and flutter are abnormal heart rhythms in which the atria, or upper chambers of the heart, are out of sync with the ventricles): 8 people, 61.54%
Thrombosis (formation of a blood clot inside a blood vessel): 7 people, 53.85%
Dizziness: 7 people, 53.85%
Pneumonia: 7 people, 53.85%
Intervertebral Disc Degeneration (spinal disc degeneration): 7 people, 53.85%
Injury: 7 people, 53.85%
Heart Rate Irregular: 6 people, 46.15%

What are the existing conditions these people have? *

Paget's Disease (disorder that involves abnormal bone destruction and regrowth, which results in deformity): 4 people, 30.77%
Glaucoma (increased fluid pressure in the eye with vision loss): 4 people, 30.77%
Arthritis (form of joint disorder that involves inflammation of one or more joints): 4 people, 30.77%
Neuralgia (pain in one or more nerves): 1 person, 7.69%

* Approximation only. Some reports may have incomplete information.

Do you take Tylenol w/ codeine and have Sinus node dysfunction?

- Check whether Sinus node dysfunction is associated with a drug or a condition
- Predict drug outcomes for up to one year with AI
- Get an AI agent to monitor your drugs continuously

Related studies:

Effectiveness of, long term effects of, and alternative drugs to Tylenol w/ codeine:

Tylenol w/ codeine (8,105 reports)

Sinus node dysfunction treatments and more:

Sinus node dysfunction (4,617 reports)

How severe was Sinus node dysfunction and when was it recovered:

Sinus node dysfunction in Tylenol w/ codeine

Expand to all the drugs that have ingredients of acetaminophen; codeine phosphate:

Sinus node dysfunction and drugs with ingredients of acetaminophen; codeine phosphate

Sub-studies by gender and age:

Female: 0-1 2-9 10-19 20-29 30-39 40-49 50-59 60+

Male: 0-1 2-9 10-19 20-29 30-39 40-49 50-59 60+

Browse all side effects of Tylenol w/ codeine:

a b c d e f g h i j k l m n o p q r s t u v w x y z

Browse all the drugs that are associated with Sinus node dysfunction:

Sinus node dysfunction (1,266 drugs)

Browse all the conditions that are associated with Sinus node dysfunction:

Sinus node dysfunction (834 conditions)

Drugs similar to Tylenol w/ codeine and Sinus node dysfunction :

How the study uses the data?

The study uses data from the FDA. It is based on acetaminophen; codeine phosphate (the active ingredients of Tylenol w/ codeine) and Tylenol w/ codeine (the brand name). Other drugs that have the same active ingredients (e.g. generic drugs) are not considered. Dosage of drugs is not considered in the study.

How to use the study?

DO NOT STOP MEDICATIONS without first consulting your doctor. If there are any serious or long term adverse effects discovered in the study, discuss the study with your doctor to ensure that proper medication management will be in place if applicable.

Who is eHealthMe?

With medical big data and proven AI/ML algorithms, eHealthMe provides a platform for everyone to run phase IV clinical trials. We study millions of patients and 5,000 more each day. Results of our real-world drug study have been referenced on 800+ peer-reviewed medical publications, including The Lancet, Mayo Clinic Proceedings, and Nature. Our analysis results are available to researchers, health care professionals, patients (testimonials), and software developers (open API).

WARNING, DISCLAIMER, USE FOR PUBLICATION

WARNING: Please DO NOT STOP MEDICATIONS without first consulting a physician since doing so could be hazardous to your health.

DISCLAIMER: All material available on eHealthMe.com is for informational purposes only, and is not a substitute for medical advice, diagnosis, or treatment provided by a qualified healthcare provider. All information is observation-only. Our phase IV clinical studies alone cannot establish cause-effect relationship. Different individuals may respond to medication in different ways. Every effort has been made to ensure that all information is accurate, up-to-date, and complete, but no guarantee is made to that effect. The use of the eHealthMe site and its content is at your own risk.

If you use this eHealthMe study on publication, please acknowledge it with a citation: study title, URL, accessed date.