Cymbalta and Sinus node dysfunction - a phase IV clinical study of FDA data

Summary:

Sinus node dysfunction is reported as a side effect among people who take Cymbalta (duloxetine hydrochloride), especially for people who are female, 60+ old, have been taking the drug for < 1 month also take Lipitor, and have Hypothyroidism.

The phase IV clinical study analyzes which people have Sinus node dysfunction when taking Cymbalta. It is created by eHealthMe based on reports of 145,249 people who have side effects when taking Cymbalta from the FDA, and is updated regularly.

What is Cymbalta?

Cymbalta has active ingredients of duloxetine hydrochloride. It is often used in depression. eHealthMe is studying from 154,960 Cymbalta users. Check the latest studies of Cymbalta.

What is Sinus node dysfunction?

Sinus node dysfunction (a group of abnormal heart rhythms) is found to be associated with 1,257 drugs and 834 conditions by eHealthMe. Check the latest studies of Sinus node dysfunction.

On Sep, 25, 2025

145,249 people reported to have side effects when taking Cymbalta.
Among them, 35 people (0.02%) have Sinus node dysfunction.

Could Cymbalta cause Sinus node dysfunction?

Among these 35 people:

How long have people been on Cymbalta when they have Sinus node dysfunction? *

What is the gender of people who have Sinus node dysfunction when taking Cymbalta? *

female: 60 %
male: 40 %

What is the age of people who have Sinus node dysfunction when taking Cymbalta? *

What are other drugs people take besides Cymbalta? *

What are other side effects people have besides Sinus node dysfunction? *

Bradycardia (abnormally slow heart action): 16 people, 45.71%
Fatigue (feeling of tiredness): 16 people, 45.71%
Atrial Fibrillation/flutter (atrial fibrillation and flutter are abnormal heart rhythms in which the atria, or upper chambers of the heart, are out of sync with the ventricles): 14 people, 40.00%
Nausea (feeling of having an urge to vomit): 13 people, 37.14%
Chest Pain: 12 people, 34.29%
Anaemia (lack of blood): 11 people, 31.43%
Constipation: 11 people, 31.43%
Fainting (loss of consciousness and postural tone): 11 people, 31.43%
Heart Palpitations (feelings or sensations that your heart is pounding or racing): 11 people, 31.43%
Pain: 10 people, 28.57%

What are the existing conditions these people have? *

Hypertriglyceridaemia (excess of triglycerides in the blood): 6 people, 17.14%
Non-Hodgkin's Lymphoma (malignant (cancer) cells form in the lymph system): 6 people, 17.14%
High Blood Cholesterol: 6 people, 17.14%
Hypothyroidism (abnormally low activity of the thyroid gland, resulting in retardation of growth and mental development): 6 people, 17.14%
Convulsion (muscles contract and relax rapidly and repeatedly, resulting in an uncontrolled shaking of the body): 5 people, 14.29%
Constipation: 4 people, 11.43%
Multiple Sclerosis (a nervous system disease that affects your brain and spinal cord. it damages the myelin sheath): 4 people, 11.43%
Diabetes: 3 people, 8.57%
Cataplexy (loss of muscle tone accompanied by full conscious awareness): 2 people, 5.71%
Narcolepsy (brain's inability to regulate sleep-wake cycles normally): 2 people, 5.71%

* Approximation only. Some reports may have incomplete information.

Do you take Cymbalta and have Sinus node dysfunction?

- Check whether Sinus node dysfunction is associated with a drug or a condition
- Predict drug outcomes for up to one year with AI
- Get an AI agent to monitor your drugs continuously

Related studies:

Effectiveness of, long term effects of, and alternative drugs to Cymbalta:

Cymbalta (154,960 reports)

Browse all side effects of Cymbalta:

a b c d e f g h i j k l m n o p q r s t u v w x y z

Browse all the drugs that are associated with Sinus node dysfunction:

Sinus node dysfunction (1,257 drugs)

Browse all the conditions that are associated with Sinus node dysfunction:

Sinus node dysfunction (834 conditions)

Drugs similar to Cymbalta and Sinus node dysfunction :

How the study uses the data?

The study uses data from the FDA. It is based on duloxetine hydrochloride (the active ingredients of Cymbalta) and Cymbalta (the brand name). Other drugs that have the same active ingredients (e.g. generic drugs) are not considered. Dosage of drugs is not considered in the study.

How to use the study?

DO NOT STOP MEDICATIONS without first consulting your doctor. If there are any serious or long term adverse effects discovered in the study, discuss the study with your doctor to ensure that proper medication management will be in place if applicable.

Who is eHealthMe?

With medical big data and proven AI/ML algorithms, eHealthMe provides a platform for everyone to run phase IV clinical trials. We study millions of patients and 5,000 more each day. Results of our real-world drug study have been referenced on 800+ peer-reviewed medical publications, including The Lancet, Mayo Clinic Proceedings, and Nature. Our analysis results are available to researchers, health care professionals, patients (testimonials), and software developers (open API).

WARNING, DISCLAIMER, USE FOR PUBLICATION

WARNING: Please DO NOT STOP MEDICATIONS without first consulting a physician since doing so could be hazardous to your health.

DISCLAIMER: All material available on eHealthMe.com is for informational purposes only, and is not a substitute for medical advice, diagnosis, or treatment provided by a qualified healthcare provider. All information is observation-only. Our phase IV clinical studies alone cannot establish cause-effect relationship. Different individuals may respond to medication in different ways. Every effort has been made to ensure that all information is accurate, up-to-date, and complete, but no guarantee is made to that effect. The use of the eHealthMe site and its content is at your own risk.

If you use this eHealthMe study on publication, please acknowledge it with a citation: study title, URL, accessed date.