Prozac and Sinus node dysfunction - a phase IV clinical study of FDA data

Summary:

Sinus node dysfunction is reported as a side effect among people who take Prozac (fluoxetine hydrochloride), especially for people who are female, 60+ old, have been taking the drug for 1 - 6 months also take Vioxx, and have Atrial fibrillation/flutter.

The phase IV clinical study analyzes which people have Sinus node dysfunction when taking Prozac. It is created by eHealthMe based on reports of 74,788 people who have side effects when taking Prozac from the FDA, and is updated regularly.

What is Prozac?

Prozac has active ingredients of fluoxetine hydrochloride. It is often used in depression. eHealthMe is studying from 82,977 Prozac users. Check the latest studies of Prozac.

What is Sinus node dysfunction?

Sinus node dysfunction (a group of abnormal heart rhythms) is found to be associated with 1,214 drugs and 837 conditions by eHealthMe. Check the latest studies of Sinus node dysfunction.

On Dec, 27, 2025

74,788 people reported to have side effects when taking Prozac.
Among them, 25 people (0.03%) have Sinus node dysfunction.

Could Prozac cause Sinus node dysfunction?

Among these 25 people:

How long have people been on Prozac when they have Sinus node dysfunction? *

What is the gender of people who have Sinus node dysfunction when taking Prozac? *

female: 62.5 %
male: 37.5 %

What is the age of people who have Sinus node dysfunction when taking Prozac? *

What are other drugs people take besides Prozac? *

What are other side effects people have besides Sinus node dysfunction? *

Cardiac Failure Congestive: 9 people, 36.00%
Weakness: 8 people, 32.00%
Dyspnea (difficult or laboured breathing): 8 people, 32.00%
Pain In Extremity: 7 people, 28.00%
Fatigue (feeling of tiredness): 7 people, 28.00%
Atrial Fibrillation/flutter (atrial fibrillation and flutter are abnormal heart rhythms in which the atria, or upper chambers of the heart, are out of sync with the ventricles): 7 people, 28.00%
High Blood Pressure: 6 people, 24.00%
Heart Attack: 6 people, 24.00%
Chest Pain: 6 people, 24.00%
Neuropathy Peripheral (surface nerve damage): 5 people, 20.00%

What are the existing conditions these people have? *

Atrial Fibrillation/flutter (atrial fibrillation and flutter are abnormal heart rhythms in which the atria, or upper chambers of the heart, are out of sync with the ventricles): 4 people, 16.00%
High Blood Cholesterol: 3 people, 12.00%
High Blood Pressure: 3 people, 12.00%
Multiple Sclerosis (a nervous system disease that affects your brain and spinal cord. it damages the myelin sheath): 2 people, 8.00%
Multiple Myeloma (cancer of the plasma cells): 2 people, 8.00%
Menopause (end of monthly cycles in women): 2 people, 8.00%
Hot Flush (sudden feelings of heat): 2 people, 8.00%
Glaucoma (increased fluid pressure in the eye with vision loss): 2 people, 8.00%
Endometrial Cancer: 2 people, 8.00%
Diabetes: 2 people, 8.00%

* Approximation only. Some reports may have incomplete information.

Do you take Prozac and have Sinus node dysfunction?

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Related studies:

Effectiveness of, long term effects of, and alternative drugs to Prozac:

Prozac (82,977 reports)

Browse all side effects of Prozac:

a b c d e f g h i j k l m n o p q r s t u v w x y z

Browse all the drugs that are associated with Sinus node dysfunction:

Sinus node dysfunction (1,214 drugs)

Browse all the conditions that are associated with Sinus node dysfunction:

Sinus node dysfunction (837 conditions)

Drugs similar to Prozac and Sinus node dysfunction :

How the study uses the data?

The study uses data from the FDA. It is based on fluoxetine hydrochloride (the active ingredients of Prozac) and Prozac (the brand name). Other drugs that have the same active ingredients (e.g. generic drugs) are not considered. Dosage of drugs is not considered in the study.

How to use the study?

DO NOT STOP MEDICATIONS without first consulting your doctor. If there are any serious or long term adverse effects discovered in the study, discuss the study with your doctor to ensure that proper medication management will be in place if applicable.

Who is eHealthMe?

With medical big data and proven AI/ML algorithms, eHealthMe provides a platform for everyone to run phase IV clinical trials. We study millions of patients and 5,000 more each day. Results of our real-world drug study have been referenced on 800+ peer-reviewed medical publications, including The Lancet, Mayo Clinic Proceedings, and Nature. Our analysis results are available to researchers, health care professionals, patients (testimonials), and software developers (open API).

WARNING, DISCLAIMER, USE FOR PUBLICATION

WARNING: Please DO NOT STOP MEDICATIONS without first consulting a physician since doing so could be hazardous to your health.

DISCLAIMER: All material available on eHealthMe.com is for informational purposes only, and is not a substitute for medical advice, diagnosis, or treatment provided by a qualified healthcare provider. All information is observation-only. Our phase IV clinical studies alone cannot establish cause-effect relationship. Different individuals may respond to medication in different ways. Every effort has been made to ensure that all information is accurate, up-to-date, and complete, but no guarantee is made to that effect. The use of the eHealthMe site and its content is at your own risk.

If you use this eHealthMe study on publication, please acknowledge it with a citation: study title, URL, accessed date.