Wellbutrin and Sinus node dysfunction - a phase IV clinical study of FDA data

Summary:

Sinus node dysfunction is reported as a side effect among people who take Wellbutrin (bupropion hydrochloride), especially for people who are female, 60+ old, also take Digoxin, and have High blood cholesterol.

The phase IV clinical study analyzes which people have Sinus node dysfunction when taking Wellbutrin. It is created by eHealthMe based on reports of 101,581 people who have side effects when taking Wellbutrin from the FDA, and is updated regularly.

What is Wellbutrin?

Wellbutrin has active ingredients of bupropion hydrochloride. It is often used in depression. eHealthMe is studying from 117,088 Wellbutrin users. Check the latest studies of Wellbutrin.

What is Sinus node dysfunction?

Sinus node dysfunction (a group of abnormal heart rhythms) is found to be associated with 1,187 drugs and 840 conditions by eHealthMe. Check the latest studies of Sinus node dysfunction.

On Jan, 22, 2026

101,581 people reported to have side effects when taking Wellbutrin.
Among them, 22 people (0.02%) have Sinus node dysfunction.

Could Wellbutrin cause Sinus node dysfunction?

Among these 22 people:

What is the gender of people who have Sinus node dysfunction when taking Wellbutrin? *

female: 54.55 %
male: 45.45 %

What is the age of people who have Sinus node dysfunction when taking Wellbutrin? *

What are other drugs people take besides Wellbutrin? *

Digoxin: 9 people, 40.91%
Lipitor: 6 people, 27.27%
Cymbalta: 6 people, 27.27%
Coumadin: 5 people, 22.73%
Keflex: 5 people, 22.73%
Carbamazepine: 5 people, 22.73%
Trazodone Hydrochloride: 4 people, 18.18%
Norvasc: 4 people, 18.18%
Toprol-Xl: 4 people, 18.18%
Aspirin: 4 people, 18.18%

What are other side effects people have besides Sinus node dysfunction? *

Atrial Fibrillation/flutter (atrial fibrillation and flutter are abnormal heart rhythms in which the atria, or upper chambers of the heart, are out of sync with the ventricles): 7 people, 31.82%
Weakness: 7 people, 31.82%
Dizziness: 6 people, 27.27%
High Blood Pressure: 6 people, 27.27%
Fatigue (feeling of tiredness): 6 people, 27.27%
Coronary Heart Disease (narrowing or blockage of the coronary arteries): 5 people, 22.73%
Bradycardia (abnormally slow heart action): 5 people, 22.73%
Back Pain: 5 people, 22.73%
Pain: 5 people, 22.73%
Pain In Extremity: 5 people, 22.73%

What are the existing conditions these people have? *

Non-Hodgkin's Lymphoma (malignant (cancer) cells form in the lymph system): 6 people, 27.27%
Hypothyroidism (abnormally low activity of the thyroid gland, resulting in retardation of growth and mental development): 6 people, 27.27%
Hypertriglyceridaemia (excess of triglycerides in the blood): 6 people, 27.27%
High Blood Cholesterol: 6 people, 27.27%
Atrial Fibrillation/flutter (atrial fibrillation and flutter are abnormal heart rhythms in which the atria, or upper chambers of the heart, are out of sync with the ventricles): 5 people, 22.73%
Convulsion (muscles contract and relax rapidly and repeatedly, resulting in an uncontrolled shaking of the body): 5 people, 22.73%
Arrhythmias (irregular heartbeat): 2 people, 9.09%
Cardiac Failure Congestive: 2 people, 9.09%
Hepatitis C: 2 people, 9.09%
Diabetes: 2 people, 9.09%

* Approximation only. Some reports may have incomplete information.

Do you take Wellbutrin and have Sinus node dysfunction?

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Related studies:

Effectiveness of, long term effects of, and alternative drugs to Wellbutrin:

Wellbutrin (117,088 reports)

Browse all side effects of Wellbutrin:

a b c d e f g h i j k l m n o p q r s t u v w x y z

Browse all the drugs that are associated with Sinus node dysfunction:

Sinus node dysfunction (1,187 drugs)

Browse all the conditions that are associated with Sinus node dysfunction:

Sinus node dysfunction (840 conditions)

Drugs similar to Wellbutrin and Sinus node dysfunction :

How the study uses the data?

The study uses data from the FDA. It is based on bupropion hydrochloride (the active ingredients of Wellbutrin) and Wellbutrin (the brand name). Other drugs that have the same active ingredients (e.g. generic drugs) are not considered. Dosage of drugs is not considered in the study.

How to use the study?

DO NOT STOP MEDICATIONS without first consulting your doctor. If there are any serious or long term adverse effects discovered in the study, discuss the study with your doctor to ensure that proper medication management will be in place if applicable.

Who is eHealthMe?

With medical big data and proven AI/ML algorithms, eHealthMe provides a platform for everyone to run phase IV clinical trials. We study millions of patients and 5,000 more each day. Results of our real-world drug study have been referenced on 800+ peer-reviewed medical publications, including The Lancet, Mayo Clinic Proceedings, and Nature. Our analysis results are available to researchers, health care professionals, patients (testimonials), and software developers (open API).

WARNING, DISCLAIMER, USE FOR PUBLICATION

WARNING: Please DO NOT STOP MEDICATIONS without first consulting a physician since doing so could be hazardous to your health.

DISCLAIMER: All material available on eHealthMe.com is for informational purposes only, and is not a substitute for medical advice, diagnosis, or treatment provided by a qualified healthcare provider. All information is observation-only. Our phase IV clinical studies alone cannot establish cause-effect relationship. Different individuals may respond to medication in different ways. Every effort has been made to ensure that all information is accurate, up-to-date, and complete, but no guarantee is made to that effect. The use of the eHealthMe site and its content is at your own risk.

If you use this eHealthMe study on publication, please acknowledge it with a citation: study title, URL, accessed date.