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Sertraline and Sinus node dysfunction - a phase IV clinical study of FDA data

Summary:

Sinus node dysfunction is reported as a side effect among people who take Sertraline (sertraline hydrochloride), especially for people who are female, 60+ old, also take Aspirin, and have Delusional disorder, persecutory type.

The phase IV clinical study analyzes which people have Sinus node dysfunction when taking Sertraline. It is created by eHealthMe based on reports of 146,463 people who have side effects when taking Sertraline from the FDA, and is updated regularly.

What is Sertraline?

Sertraline has active ingredients of sertraline hydrochloride. It is often used in depression. eHealthMe is studying from 153,265 Sertraline users. Check the latest studies of Sertraline.

What is Sinus node dysfunction?

Sinus node dysfunction (a group of abnormal heart rhythms) is found to be associated with 1,271 drugs and 834 conditions by eHealthMe. Check the latest studies of Sinus node dysfunction.

On Aug, 18, 2025

146,463 people reported to have side effects when taking Sertraline.
Among them, 36 people (0.02%) have Sinus node dysfunction.

Could Sertraline cause Sinus node dysfunction?

Among these 36 people:

What is the gender of people who have Sinus node dysfunction when taking Sertraline? *

  • female: 58.33 %
  • male: 41.67 %

What is the age of people who have Sinus node dysfunction when taking Sertraline? *

  • 0-1: 2.94 %
  • 2-9: 0.0 %
  • 10-19: 0.0 %
  • 20-29: 14.71 %
  • 30-39: 2.94 %
  • 40-49: 0.0 %
  • 50-59: 17.65 %
  • 60+: 61.76 %

What are other drugs people take besides Sertraline? *

  1. Aspirin: 14 people, 38.89%
  2. Simvastatin: 10 people, 27.78%
  3. Zopiclone: 6 people, 16.67%
  4. Lipitor: 6 people, 16.67%
  5. Klor-Con: 6 people, 16.67%
  6. Furosemide: 5 people, 13.89%
  7. Norvasc: 5 people, 13.89%
  8. Lasix: 5 people, 13.89%
  9. Lotrel: 5 people, 13.89%
  10. Ambien: 5 people, 13.89%

What are other side effects people have besides Sinus node dysfunction? *

  1. Dyspnea (difficult or laboured breathing): 12 people, 33.33%
  2. Fatigue (feeling of tiredness): 10 people, 27.78%
  3. Cardiac Failure Congestive: 9 people, 25.00%
  4. Ventricular Tachycardia (rapid heartbeat that originates in one of the lower chambers (the ventricles) of the heart): 9 people, 25.00%
  5. Atrial Fibrillation/flutter (atrial fibrillation and flutter are abnormal heart rhythms in which the atria, or upper chambers of the heart, are out of sync with the ventricles): 7 people, 19.44%
  6. Dizziness: 7 people, 19.44%
  7. Torsade De Pointes (a abnormal heart rate with abnormal beating pattern): 6 people, 16.67%
  8. Cardiac Arrest: 6 people, 16.67%
  9. Chest Pain: 6 people, 16.67%
  10. Hypocalcaemia (levels of calcium in blood serum are abnormally low): 6 people, 16.67%

What are the existing conditions these people have? *

  1. High Blood Pressure: 4 people, 11.11%
  2. Delusional Disorder, Persecutory Type (a belief that they (or someone close to them) are being mistreated): 4 people, 11.11%
  3. Bipolar Disorder (mood disorder): 2 people, 5.56%
  4. Multiple Myeloma (cancer of the plasma cells): 2 people, 5.56%
  5. Mania (a state of abnormally elevated or irritable mood): 2 people, 5.56%
  6. Coronary Heart Disease (narrowing or blockage of the coronary arteries): 2 people, 5.56%
  7. Cystic Fibrosis (disease of the secretary glands): 2 people, 5.56%
  8. Pulmonary Embolism (blockage of the main artery of the lung): 1 person, 2.78%
  9. Diabetes: 1 person, 2.78%
  10. Attention Deficit Hyperactivity Disorder (a chronic condition including attention difficulty, hyperactivity, and impulsiveness): 1 person, 2.78%

* Approximation only. Some reports may have incomplete information.

Do you take Sertraline and have Sinus node dysfunction?

- Check whether Sinus node dysfunction is associated with a drug or a condition
- Predict drug outcomes for up to one year with AI
- Get an AI agent to monitor your drugs continuously

Related studies:

Effectiveness of, long term effects of, and alternative drugs to Sertraline:

Sinus node dysfunction treatments and more:

How severe was Sinus node dysfunction and when was it recovered:

Expand to all the drugs that have ingredients of sertraline hydrochloride:

Sub-studies by gender and age:

Female: 0-1 2-9 10-19 20-29 30-39 40-49 50-59 60+

Male: 0-1 2-9 10-19 20-29 30-39 40-49 50-59 60+

Browse all side effects of Sertraline:

a b c d e f g h i j k l m n o p q r s t u v w x y z

Browse all the drugs that are associated with Sinus node dysfunction:

Browse all the conditions that are associated with Sinus node dysfunction:

Drugs similar to Sertraline and Sinus node dysfunction :

Related publications that referenced our studies

How the study uses the data?

The study uses data from the FDA. It is based on sertraline hydrochloride (the active ingredients of Sertraline) and Sertraline (the brand name). Other drugs that have the same active ingredients (e.g. generic drugs) are not considered. Dosage of drugs is not considered in the study.

How to use the study?

DO NOT STOP MEDICATIONS without first consulting your doctor. If there are any serious or long term adverse effects discovered in the study, discuss the study with your doctor to ensure that proper medication management will be in place if applicable.

Who is eHealthMe?

With medical big data and proven AI/ML algorithms, eHealthMe provides a platform for everyone to run phase IV clinical trials. We study millions of patients and 5,000 more each day. Results of our real-world drug study have been referenced on 800+ peer-reviewed medical publications, including The Lancet, Mayo Clinic Proceedings, and Nature. Our analysis results are available to researchers, health care professionals, patients (testimonials), and software developers (open API).

WARNING, DISCLAIMER, USE FOR PUBLICATION

WARNING: Please DO NOT STOP MEDICATIONS without first consulting a physician since doing so could be hazardous to your health.

DISCLAIMER: All material available on eHealthMe.com is for informational purposes only, and is not a substitute for medical advice, diagnosis, or treatment provided by a qualified healthcare provider. All information is observation-only. Our phase IV clinical studies alone cannot establish cause-effect relationship. Different individuals may respond to medication in different ways. Every effort has been made to ensure that all information is accurate, up-to-date, and complete, but no guarantee is made to that effect. The use of the eHealthMe site and its content is at your own risk.

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