Naproxen and Sinus node dysfunction - a phase IV clinical study of FDA data

Summary:

Sinus node dysfunction is reported as a side effect among people who take Naproxen (naproxen), especially for people who are female, 60+ old, also take Hydrochlorothiazide, and have High blood pressure.

The phase IV clinical study analyzes which people have Sinus node dysfunction when taking Naproxen. It is created by eHealthMe based on reports of 68,942 people who have side effects when taking Naproxen from the FDA, and is updated regularly.

What is Naproxen?

Naproxen has active ingredients of naproxen. It is often used in pain. eHealthMe is studying from 72,028 Naproxen users. Check the latest studies of Naproxen.

What is Sinus node dysfunction?

Sinus node dysfunction (a group of abnormal heart rhythms) is found to be associated with 1,217 drugs and 837 conditions by eHealthMe. Check the latest studies of Sinus node dysfunction.

On Nov, 21, 2025

68,942 people reported to have side effects when taking Naproxen.
Among them, 19 people (0.03%) have Sinus node dysfunction.

Could Naproxen cause Sinus node dysfunction?

Among these 19 people:

What is the gender of people who have Sinus node dysfunction when taking Naproxen? *

female: 83.33 %
male: 16.67 %

What is the age of people who have Sinus node dysfunction when taking Naproxen? *

What are other drugs people take besides Naproxen? *

What are other side effects people have besides Sinus node dysfunction? *

Arrhythmia Supraventricular (irregular heartbeat supraventricular origin): 7 people, 36.84%
Fatigue (feeling of tiredness): 6 people, 31.58%
Heart Palpitations (feelings or sensations that your heart is pounding or racing): 6 people, 31.58%
Anaemia (lack of blood): 5 people, 26.32%
Primary Myelofibrosis (primary disorder of the bone marrow): 4 people, 21.05%
Dizziness: 4 people, 21.05%
Atrial Fibrillation/flutter (atrial fibrillation and flutter are abnormal heart rhythms in which the atria, or upper chambers of the heart, are out of sync with the ventricles): 4 people, 21.05%
Balance Disorder: 4 people, 21.05%
Nausea (feeling of having an urge to vomit): 4 people, 21.05%
Listless (lack of interest, energy, or spirit): 4 people, 21.05%

What are the existing conditions these people have? *

High Blood Pressure: 11 people, 57.89%
Primary Myelofibrosis (primary disorder of the bone marrow): 4 people, 21.05%
Polycythaemia Vera (blood disorder in which the bone marrow makes too many red blood cells): 4 people, 21.05%
Itching: 4 people, 21.05%
Systemic Lupus Erythematosus (an autoimmune disease, which means the body's immune system mistakenly, attacks healthy tissue): 2 people, 10.53%
Joint Pain: 2 people, 10.53%
Type 2 Diabetes: 1 person, 5.26%
Osteoporosis (bones weak and more likely to break): 1 person, 5.26%
Hypertonic Bladder (bladder-storage function that causes a sudden urge to urinate): 1 person, 5.26%
Chronic Lymphocytic Leukaemia (cancer in which the bone marrow makes too many lymphocytes (a type of white blood cell)): 1 person, 5.26%

* Approximation only. Some reports may have incomplete information.

Do you take Naproxen and have Sinus node dysfunction?

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Related studies:

Effectiveness of, long term effects of, and alternative drugs to Naproxen:

Naproxen (72,028 reports)

Browse all side effects of Naproxen:

a b c d e f g h i j k l m n o p q r s t u v w x y z

Browse all the drugs that are associated with Sinus node dysfunction:

Sinus node dysfunction (1,217 drugs)

Browse all the conditions that are associated with Sinus node dysfunction:

Sinus node dysfunction (837 conditions)

Drugs similar to Naproxen and Sinus node dysfunction :

How the study uses the data?

The study uses data from the FDA. It is based on naproxen (the active ingredients of Naproxen) and Naproxen (the brand name). Other drugs that have the same active ingredients (e.g. generic drugs) are not considered. Dosage of drugs is not considered in the study.

How to use the study?

DO NOT STOP MEDICATIONS without first consulting your doctor. If there are any serious or long term adverse effects discovered in the study, discuss the study with your doctor to ensure that proper medication management will be in place if applicable.

Who is eHealthMe?

With medical big data and proven AI/ML algorithms, eHealthMe provides a platform for everyone to run phase IV clinical trials. We study millions of patients and 5,000 more each day. Results of our real-world drug study have been referenced on 800+ peer-reviewed medical publications, including The Lancet, Mayo Clinic Proceedings, and Nature. Our analysis results are available to researchers, health care professionals, patients (testimonials), and software developers (open API).

WARNING, DISCLAIMER, USE FOR PUBLICATION

WARNING: Please DO NOT STOP MEDICATIONS without first consulting a physician since doing so could be hazardous to your health.

DISCLAIMER: All material available on eHealthMe.com is for informational purposes only, and is not a substitute for medical advice, diagnosis, or treatment provided by a qualified healthcare provider. All information is observation-only. Our phase IV clinical studies alone cannot establish cause-effect relationship. Different individuals may respond to medication in different ways. Every effort has been made to ensure that all information is accurate, up-to-date, and complete, but no guarantee is made to that effect. The use of the eHealthMe site and its content is at your own risk.

If you use this eHealthMe study on publication, please acknowledge it with a citation: study title, URL, accessed date.