Vytorin and Venous insufficiency - a phase IV clinical study of FDA data

Summary:

Venous insufficiency is reported as a side effect among people who take Vytorin (ezetimibe; simvastatin), especially for people who are female, 60+ old, also take Nexium, and have Osteopenia.

The phase IV clinical study analyzes which people have Venous insufficiency when taking Vytorin. It is created by eHealthMe based on reports of 19,379 people who have side effects when taking Vytorin from the FDA, and is updated regularly.

What is Vytorin?

Vytorin has active ingredients of ezetimibe; simvastatin. It is often used in high blood cholesterol. eHealthMe is studying from 20,084 Vytorin users. Check the latest studies of Vytorin.

What is Venous insufficiency?

Venous insufficiency (poor circulation of blood caused by damaged or enlarged veins) is found to be associated with 384 drugs and 558 conditions by eHealthMe. Check the latest studies of Venous insufficiency.

eHealthMe: drug outcomes in the real world

eHealthMe runs one of the largest post-marketing drug safety studies in the world. We study millions of patients and 5,000 more each day. Our data-driven phase IV clinical trials have been referenced on 800+ peer-reviewed medical publications including The Lancet, Mayo Clinic Proceedings, and Nature. Tools to study our phase IV findings are available to the public, anonymous and free >>>.

On Aug, 26, 2026

19,379 people reported to have side effects when taking Vytorin.
Among them, 14 people (0.07%) have Venous insufficiency.

Could Vytorin cause Venous insufficiency?

Among these 14 people:

What is the gender of people who have Venous insufficiency when taking Vytorin? *

female: 100 %
male: 0.0 %

What is the age of people who have Venous insufficiency when taking Vytorin? *

What are other drugs people take besides Vytorin? *

What are other side effects people have besides Venous insufficiency? *

Muscle Spasms (muscle contraction): 7 people, 50.00%
Pain In Extremity: 7 people, 50.00%
Femur Fracture: 6 people, 42.86%
Fall: 6 people, 42.86%
Haemorrhoids (a swollen vein or group of veins in the region of the anus): 6 people, 42.86%
Arthropathy: 6 people, 42.86%
Device Failure: 6 people, 42.86%
Anaemia (lack of blood): 6 people, 42.86%
Lower Gastrointestinal Haemorrhage (bleeding in the large intestine, rectum, or anus is called lower gi bleeding): 5 people, 35.71%
Limb Discomfort (discomfort in leg): 5 people, 35.71%

What are the existing conditions these people have? *

Osteopenia (a condition where bone mineral density is lower than normal): 5 people, 35.71%
Hypothyroidism (abnormally low activity of the thyroid gland, resulting in retardation of growth and mental development): 4 people, 28.57%
Rheumatoid Arthritis (a chronic progressive disease causing inflammation in the joints): 2 people, 14.29%
Reflux Oesophagitis (an oesophageal mucosal injury that occurs of gastric contents into the oesophagus): 2 people, 14.29%
Senile Osteoporosis (weak bones with ageing): 1 person, 7.14%
Pain: 1 person, 7.14%
Osteoporosis (bones weak and more likely to break): 1 person, 7.14%
Migraine (headache): 1 person, 7.14%
Hyperlipidaemia (presence of excess lipids in the blood): 1 person, 7.14%
Gastroesophageal Reflux Disease (a condition in which stomach contents leak backward from the stomach into the oesophagus): 1 person, 7.14%

* Approximation only. Some reports may have incomplete information.

Do you take Vytorin and have Venous insufficiency?

- Check whether Venous insufficiency is associated with a drug or a condition
- Predict drug outcomes for up to one year with AI
- Get an AI agent to monitor your drugs continuously

Related studies:

Effectiveness of, long term effects of, and alternative drugs to Vytorin:

Vytorin (20,084 reports)

Browse all side effects of Vytorin:

a b c d e f g h i j k l m n o p q r s t u v w x y z

Browse all the drugs that are associated with Venous insufficiency:

Venous insufficiency (384 drugs)

Browse all the conditions that are associated with Venous insufficiency:

Venous insufficiency (558 conditions)

How the study uses the data?

The study uses data from the FDA. It is based on ezetimibe; simvastatin (the active ingredients of Vytorin) and Vytorin (the brand name). Other drugs that have the same active ingredients (e.g. generic drugs) are not considered. Dosage of drugs is not considered in the study.

How to use the study?

DO NOT STOP MEDICATIONS without first consulting your doctor. If there are any serious or long term adverse effects discovered in the study, discuss the study with your doctor to ensure that proper medication management will be in place if applicable.

Who is eHealthMe?

With medical big data and proven AI/ML algorithms, eHealthMe provides a platform for everyone to run phase IV clinical trials. We study millions of patients and 5,000 more each day. Results of our real-world drug study have been referenced on 800+ peer-reviewed medical publications, including The Lancet, Mayo Clinic Proceedings, and Nature. Our analysis results are available to researchers, health care professionals, patients (testimonials), and software developers (open API).

WARNING, DISCLAIMER, USE FOR PUBLICATION

WARNING: Please DO NOT STOP MEDICATIONS without first consulting a physician since doing so could be hazardous to your health.

DISCLAIMER: All material available on eHealthMe.com is for informational purposes only, and is not a substitute for medical advice, diagnosis, or treatment provided by a qualified healthcare provider. All information is observation-only. Our phase IV clinical studies alone cannot establish cause-effect relationship. Different individuals may respond to medication in different ways. Every effort has been made to ensure that all information is accurate, up-to-date, and complete, but no guarantee is made to that effect. The use of the eHealthMe site and its content is at your own risk.

If you use this eHealthMe study on publication, please acknowledge it with a citation: study title, URL, accessed date.